Looking deeper into vertebrate development

Jacobs, Russell E.; Ahrens, Eric T.; Meade, Thomas J.; Fraser, Scott E.

doi:10.1016/s0962-8924(98)01435-4

Cited by 70 publications

(25 citation statements)

References 8 publications

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“…The first of these methods is magnetic resonance (MR) diffusion tensor microimaging (DTI) (Jacobs et al, 1999;Mori et al, 2001). Unlike standard MR imaging (MRI) based on T1 and T2 relaxation properties of water molecules, DTI reveals the locations and orientations of axon tracts by distinguishing regions in which water (the major repository of protons) shows a spatial anisotropy in its diffusion.…”

Section: Introductionmentioning

confidence: 99%

Axonal Growth and Guidance Defects inFrizzled3Knock-Out Mice: A Comparison of Diffusion Tensor Magnetic Resonance Imaging, Neurofilament Staining, and Genetically Directed Cell Labeling

Wang¹,

Zhang²,

Mori³

et al. 2006

J. Neurosci.

120

122

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Section: Introductionmentioning

confidence: 99%

Axonal Growth and Guidance Defects inFrizzled3Knock-Out Mice: A Comparison of Diffusion Tensor Magnetic Resonance Imaging, Neurofilament Staining, and Genetically Directed Cell Labeling

Wang¹,

Zhang²,

Mori³

et al. 2006

J. Neurosci.

120

122

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“…Ces é tudes sont principalement basé es sur des techniques de pondé ration T1, T2 où de diffusion [29][30][31][32][33]. Les ré sultats obtenus ont suscité le besoin d'atlas d'IRM de ré fé rence de l'embryon et du nouveau-né sain pour pouvoir diffé -rencier les effets dus au dé veloppement cé ré bral normal de ceux dus aux mutations ou aux lé sions chez le rat et la souris [34][35][36][37][38] en utilisant des pondé rations T1, T2 et diffusion, mais aussi des é tudes par imagerie du tenseur de diffusion [39,40]. Cette derniè re technique permet de dé terminer l'orientation des fibres nerveuses et donc d'obtenir une cartographie anatomique de l'organisation du tissu cé ré bral.…”

Section: Imagerie De Ré Sonance Magné Tique Du Cerveau En Dé Veloppementunclassified

Manganèse et imagerie de résonance magnétique du développement cérébral

Gillet

Po²,

Dupont

et al. 2010

Comptes Rendus. Chimie

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“…Recent developments in MR imaging have enabled direct in-vivo imaging at high resolution (∼50 µm) (Johnson 1993;Jacobs 1999). This approach is largely based on labelling cells with superparamagnetic iron oxide (SPIO) particles that permit visualisation and tracking of cells using MRI based on the large susceptibility artefacts (T * 2 -effect) produced by iron oxide .…”

Section: Direct Molecular Imagingmentioning

confidence: 99%

Molecular Imaging: Reporter Gene Imaging

Serganova

Mayer-Kukuck

Huang

et al. 2008

Molecular Imaging II

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Non-invasive in-vivo molecular genetic imaging developed over the past decade and predominantly utilises radiotracer (PET, gamma camera, autoradiography), magnetic resonance and optical imaging technology. Molecular genetic imaging has its roots in both molecular biology and cell biology. The convergence of these disciplines and imaging modalities has provided the opportunity to address new research questions, including oncogenesis, tumour maintenance and progression, as well as responses to molecular-targeted therapy. Three different imaging strategies are described: (1) "bio-marker" or "surrogate" imaging; (2) "direct" imaging of specific molecules and pathway activity; (3) "indirect" reporter gene imaging. Examples of each imaging strategy are presented and discussed. Several applications of PET- and optical-based reporter imaging are demonstrated, including signal transduction pathway monitoring, oncogenesis in genetic mouse models, endogenous molecular genetic/biological processes and the response to therapy in animal models of human disease. Molecular imaging studies will compliment established ex-vivo molecular-biological assays that require tissue sampling by providing a spatial and a temporal dimension to our understanding of disease development and progression, as well as response to treatment. Although molecular imaging studies are currently being performed primarily in experimental animals, we optimistically expect they will be translated to human subjects with cancer and other diseases in the near future.

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Looking deeper into vertebrate development

Cited by 70 publications

References 8 publications

Axonal Growth and Guidance Defects inFrizzled3Knock-Out Mice: A Comparison of Diffusion Tensor Magnetic Resonance Imaging, Neurofilament Staining, and Genetically Directed Cell Labeling

Axonal Growth and Guidance Defects inFrizzled3Knock-Out Mice: A Comparison of Diffusion Tensor Magnetic Resonance Imaging, Neurofilament Staining, and Genetically Directed Cell Labeling

Manganèse et imagerie de résonance magnétique du développement cérébral

Molecular Imaging: Reporter Gene Imaging

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