LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes
Jin Li,
Jie Zhu,
Yamei Deng
et al.
Abstract:Proteotoxicity is a contributor to the development of type 2 diabetes (T2D), but it is unknown whether protein misfolding in T2D is generalized or has special features. Here, we report a robust accumulation of misfolded proteins within the mitochondria of human pancreatic islets in T2D and elucidate its impact on β cell viability. Surprisingly, quantitative proteomics studies of protein aggregates reveal that human islets from donors with T2D have a signature more closely resembling mitochondrial rather than E… Show more
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