Lonicerae Japonicae Flos attenuates diabetic retinopathy by inhibiting retinal angiogenesis

Zhou, Liang-Yun; Zhang, Tianyu; Lü, Bin; Yu, Zengyang; Mei, Xiyu; Abulizi, Palida; Ji, Lili

doi:10.1016/j.jep.2016.05.039

Cited by 34 publications

(29 citation statements)

References 28 publications

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“…However, there was a tendency of higher VEGF‐A expression in the CGA15, CGA30, and CGA60 groups than in the BCCO group. Apparently CGA exerts paradoxical effects on physiological and pathological conditions (Bagdas et al., ; Park, Hwang, Park, & Lee, ) In pathological conditions such as diabetic retinopathy (Zhou et al., ) or adenocarcinoma cell culture (Park et al., ), CGA inhibits VEGF expression. On the other hand, in physiological conditions, for example, in wound repair or postischemia, CGA stimulates VEGF expression (Bagdas et al., ; Fagan et al., ).…”

Section: Discussionmentioning

confidence: 99%

Chlorogenic acid ameliorates memory loss and hippocampal cell death after transient global ischemia

Hermawati

Arfian

Mustofa

et al. 2019

Eur J of Neuroscience

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Chlorogenic acid (CGA) is known to have antioxidant potentials, yet the effect of CGA on brain ischemia has not been sufficiently understood. Brain ischemia such as transient global ischemia disrupts many areas of the brain of rats, including the hippocampus. Male Wistar rats were randomly assigned into five groups, that is, sham‐operated (SO), bilateral common carotid occlusion (BCCO), and BCCO+ 15, 30, and 60 mg/kg bw CGA groups (CGA15, CGA30, and CGA60, respectively). Brain ischemia was induced in Wistar rats with BCCO for 20 min followed by intraperitoneal injection of CGA. The rats were examined for the spatial memory in a Morris water maze test on the 3rd day and were euthanized on the 10th day after BCCO. The total number of pyramidal cells was estimated, and the mRNA expressions of Bcl2, Bax, caspase‐3, SOD2, SOD1, GPx, ET‐1, eNOS, CD31, and VEGF‐A were measured. The BCCO group spent less time and distance in the target quadrant than any other group in the spatial memory retention test. The CA1 pyramidal cell numbers in the BCCO and CGA15 groups were lower than in the CGA30 and CGA60 groups. The mRNA expressions of Bcl2, SOD2, and CD31 in the BCCO group were lower than in the CGA15, CGA30, and CGA60 groups. The ET‐1 expression was higher in the BCCO and CGA15 groups than in the SO, CGA30, and CGA60 groups. CGA improves the spatial memory and prevents the CA1 pyramidal cell death after BCCO by increasing Bcl2, SOD2, and CD31 expressions and decreasing ET‐1 expression.

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Section: Discussionmentioning

confidence: 99%

Chlorogenic acid ameliorates memory loss and hippocampal cell death after transient global ischemia

Hermawati

Arfian

Mustofa

et al. 2019

Eur J of Neuroscience

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“…Thus, the role of CA in the prevention and treatment of DR has been the subject of intense research. Treatment of DM mice with honeysuckle extract, shown by high-efficiency liquid chromatography to mainly contain CA, suppressed STZ-induced retinal vascular proliferation and reduced content of vascular endothelial growth factor Journal of Immunology Research (VEGFs) in serum [63]. Also, in cellular and animal experiments, CA counteracts the effect of hypoxia-inducible factor 1-α and decreases VEGF expression during DR, thus improving retinal neovascularization.…”

Section: Effects Of Ca On Diabetic Retinopathy (Dr)mentioning

confidence: 99%

Use of Chlorogenic Acid against Diabetes Mellitus and Its Complications

Yan

Zhou²,

Ke³

et al. 2020

Journal of Immunology Research

102

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Chlorogenic acid (CA) is a phenolic compound commonly found in human plant-based diets. CA is the main component of many traditional Chinese medicine preparations, and in recent years, it has been found to have hypoglycemic, hypolipidemic, anti-inflammatory, antioxidant, and other pharmacological properties. Specifically, CA relieves the effects of, and prevents, diabetes mellitus (DM). In addition, CA is also beneficial against complications arising from DM, such as diabetic nephropathy (DN), diabetic retinopathy (DR), and diabetic peripheral neuropathy (DPN). Herein, we review the use of CA in the prevention and treatment of DM and its complications, providing a background for further research and medical uses.

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“…L. japonicae Flos decreases retinal angiogenesis in diabetic mice and reduces VEGF-induced tube formation owing to the presence of chlorogenic acid, caffeic acid, and luteolin [ 45 ]. Chlorogenic acid is considered to be the main compound involved in suppression of retinal angiogenesis and works by decreasing VEGF expression, which is followed by a decreased breakdown of BRB, and of vascular leakage.…”

Section: Resultsmentioning

confidence: 99%

Phytochemicals: Target-Based Therapeutic Strategies for Diabetic Retinopathy

Parveen

Kim

et al. 2018

Molecules

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Background: A variety of causative factors are involved in the initiation of diabetic retinopathy (DR). Current antidiabetic therapies are expensive and not easily accessible by the public. Furthermore, the use of multiple synthetic drugs leads to severe side effects, which worsen the diabetic patient’s condition. Medicinal plants and their derived phytochemicals are considered safe and effective treatment and their consumption can reduce the DR risk. In this article, we discuss a variety of medicinal plants, and their noteworthy bio-active constituents, that will be utilized as target based therapeutic strategies for DR. Methods: A broad-spectrum study was conducted using published English works in various electronic databases including Science Direct, PubMed, Scopus, and Google Scholar. Results: Targeting the multiple pathological factors including ROS, AGEs formation, hexosamine flux, PARP, PKC, and MAPK activation through variety of bioactive constituents in medicinal plants, diabetes progression can be delayed with improved loss of vision. Conclusions: Data reveals that traditional herbs and their prominent bioactive components control and normalize pathological cellular factors involved in DR progression. Therefore, studies should be carried out to explore the protective retinopathy effects of medicinal plants using experimental animal and humans models.

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Lonicerae Japonicae Flos attenuates diabetic retinopathy by inhibiting retinal angiogenesis

Cited by 34 publications

References 28 publications

Chlorogenic acid ameliorates memory loss and hippocampal cell death after transient global ischemia

Chlorogenic acid ameliorates memory loss and hippocampal cell death after transient global ischemia

Use of Chlorogenic Acid against Diabetes Mellitus and Its Complications

Phytochemicals: Target-Based Therapeutic Strategies for Diabetic Retinopathy

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