Longterm Survival and Associated Risk Factors in Patients with Adult-onset Idiopathic Inflammatory Myopathies and Amyopathic Dermatomyositis: Experience in a Single Institute in Japan

Yamasaki, Yoshioki; Yamada, Hisakata; Ohkubo, Michiko; Yamasaki, Masaomi; Azuma, Kohei; Ogawa, Hitoshi; Mizushima, Machiko; Ozaki, Shoichi

doi:10.3899/jrheum.101002

Cited by 119 publications

(71 citation statements)

References 40 publications

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“…Later work have confirmed this, but shown large variation in mortality rates, probably due to differences in patient selection, classification, loss to follow-up and treatment-related issues [4,5]. Peter and Bohan criteria were applied in eight studies on mortality [3,4,[24][25][26][27][28][29] but only one of them assessed an unselected population-based cohort [3]. This study, which is the largest mortality study to date, identified 248 PM/DM cases diagnosed in Finland from 1969 to 1985 through hospital discharge searches and subsequent case assignment by chart review.…”

Section: Introductionmentioning

confidence: 90%

Survival and cancer risk in an unselected and complete Norwegian idiopathic inflammatory myopathy cohort

Dobloug

Garen

Brunborg

et al. 2015

Seminars in Arthritis and Rheumatism

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Section: Introductionmentioning

confidence: 90%

Survival and cancer risk in an unselected and complete Norwegian idiopathic inflammatory myopathy cohort

Dobloug

Garen

Brunborg

et al. 2015

Seminars in Arthritis and Rheumatism

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“…1,25 Evidence for an association between PM/DM and solid tumors came first from case reports, with the reported rate of cancer varying from 6% to 60%. 1,12,23,[26][27][28][29][30] Lab investigation shows raised muscle enzymecreatine kinase, lactate dehydrogenase, aldolase, and aminotransferases; and serological test can be ANA positive, Anti Jo positive. Autoantibodies are found in a majority of patients.…”

Section: Discussionmentioning

confidence: 99%

A Fatal Presentation of Dermatomyositis

Khatiwoda

Kayastha

Khatiwada

et al. 2013

Kathmandu Univ. Med. J.

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Dermatomyositis (DM) is an autoimmune disease that mainly affects the skin, muscle, and lung. The pathogenesis of skin inflammation in DM is not well understood. We present a 40-year-old male who presented with four months history of generalized skin lesion, pain and weakness. He had elevated transaminases with detectable muscle weakness. This case highlights the need to consider dermatomyositis with skin lesion and weakness; and the use of aggressive immunosuppressive therapies due to its associated vasculopathies. Kathmandu University Medical Journal | VOL.10 | NO. 3 | ISSUE 39 | JUL- SEP 2012 | Page 78-82 DOI: http://dx.doi.org/10.3126/kumj.v10i3.8027

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“…In addition to cardiovascular, 24,25 infectious, [31][32][33] and pulmonary events, the following factors are associated with the increased mortality in DM: thrombocytopenia; 34 diabetes mellitus; 34 neoplasm; 10,34 advanced age; 34 creatine kinase levels; 35 and interstitial pulmonary disease. 35 The percentage of deaths ranges from 7.8% to 28%.…”

Section: Discussionmentioning

confidence: 99%

“…35 The percentage of deaths ranges from 7.8% to 28%. 10,[34][35][36] During follow-up, death occurred in 11.5% of the patients, an index lower than that of Chinese 34 (28,6%) and Japanese 35 (26.9%) studies, and slightly greater than the statistics of Taiwan (7.68%). 36 In our case series, sepsis was the major cause of death, followed by neoplasms, and involvement of the respiratory tract and cardiovascular system, as reported in other studies.…”

Section: Discussionmentioning

confidence: 99%

Dermatomiosite em adulto: experiência de um centro terciário brasileiro

Souza¹,

Barros²,

Levy‐Neto³

et al. 2012

Rev. Bras. Reumatol.

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Objective: To report the results of a retrospective cohort involving 139 patients with dermatomyositis, conducted from 1991 to 2011. Methods: All patients met at least four of the fi ve Bohan and Peter criteria (1975). Results: The patients' mean age at disease onset was 41.7 ± 14.1 years, and mean disease duration was 7.2 ± 5.2 years. The sample comprised 90.2% white patients and 79.9% female patients. Constitutional symptoms occurred in less than half of the patients. Cutaneous and joint involvements occurred in 95.7% and 41.7% of the patients, respectively. Incipient pneumopathy, ground glass opacities and/or pulmonary fi brosis were present in 48.2% of the patients. All patients received prednisone (1 mg/kg/day) and 51.1% also received intravenous methylprednisolone (1 g/day for three days). Several immunosuppressants were used as corticosteroid sparing agents according to tolerance, side effects and/or refractoriness. Although disease relapse (clinical and/or laboratory) occurred in 53.2% of the patients, 76.3% were in disease remission at the end of the study. The rate of severe infection was 35.3%, and herpes zoster predominated. There were 15 (10.8%) cases of cancer, 12 within one year after the diagnosis. There were 16 deaths (11.5%), and their major causes were sepsis/septic shock (27.5%), pneumopathy attributed to the disease (31.3%), neoplasms (31.3%), and cardiovascular events (12.5%). Conclusions: In this study, the clinical and laboratory data were similar to those of other population groups described in the literature, with minimal differences regarding the frequency and characteristics of the extramuscular manifestations.

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Longterm Survival and Associated Risk Factors in Patients with Adult-onset Idiopathic Inflammatory Myopathies and Amyopathic Dermatomyositis: Experience in a Single Institute in Japan

Abstract: Survival of clinically ADM and primary DM was low, mainly due to fatal ILD, compared to primary PM. Establishing therapeutic strategy for ILD may improve the survival in our patient population.

Cited by 119 publications

References 40 publications

Survival and cancer risk in an unselected and complete Norwegian idiopathic inflammatory myopathy cohort

Survival and cancer risk in an unselected and complete Norwegian idiopathic inflammatory myopathy cohort

A Fatal Presentation of Dermatomyositis

Dermatomiosite em adulto: experiência de um centro terciário brasileiro

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