2015
DOI: 10.1590/0004-282x20150096
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Longitudinally extensive transverse myelopathy in a patient with CADASIL

Abstract: A 52-year-old Brazilian man presented with a 3-year-history of progressive cognitive decline, seizures and tetraparesis with sphincter disturbances. Familial history was positive for stroke-like episodes. Examination disclosed spastic tetraparesis with posterior cord syndrome. Neuroimaging revealed a longitudinally extensive centromedullary hyperintensity in the spinal cord between C2-T1 levels and a diffuse leukoencephalopathy

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“…Oligoclonal bands in the cerebrospinal fluid (CSF), a characteristic finding in MS, are extremely uncommon in CADA-SIL, but they have been reported [22,23] . The occurrence of spinal cord lesions, especially longitudinal ones, are exceedingly rare in CADASIL and may be due to ischemia [24] but, when present, they evoke a diagnostic challenge [25] . In one family with CADASIL, 3 members presented with cord lesions in the posterocentral area, cerebral lesions in locations compatible with both demyelination and typical CADASIL, positive antinuclear antibodies and CSF oligoclonal bands [26] .…”
Section: Possible Comorbidity Of Ms and Cadasilmentioning
confidence: 99%
“…Oligoclonal bands in the cerebrospinal fluid (CSF), a characteristic finding in MS, are extremely uncommon in CADA-SIL, but they have been reported [22,23] . The occurrence of spinal cord lesions, especially longitudinal ones, are exceedingly rare in CADASIL and may be due to ischemia [24] but, when present, they evoke a diagnostic challenge [25] . In one family with CADASIL, 3 members presented with cord lesions in the posterocentral area, cerebral lesions in locations compatible with both demyelination and typical CADASIL, positive antinuclear antibodies and CSF oligoclonal bands [26] .…”
Section: Possible Comorbidity Of Ms and Cadasilmentioning
confidence: 99%