Longitudinal variability of skin prick test results

Kuehr, Joachim; Karmaus, Wilfried; Frischer, Thomas; Hendel-Kramer, Anneliese; Weiss, Kelly; Moseler, Michael; Stephan, Volker; Förster, Johannes; Urbanek, R.

doi:10.1111/j.1365-2222.1992.tb02829.x

Cited by 42 publications

(28 citation statements)

References 17 publications

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“…Four other studies [5][6][7][8] have investigated the longitudinal variability of SPTs among children. Unfortunately, direct comparison with our data is difficult because the populations studied had a different age profile and focused mainly on aeroallergens, and these studies used a different definition of a positive reaction.…”

Section: Discussionmentioning

confidence: 98%

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Patterns of sensitization to food and aeroallergens in the first 3 years of life

Dean

Venter

Pereira

et al. 2007

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 98%

“…Historical population-based studies [5][6][7][8] have shown a high long-term stability of sensitization to some specific aeroallergens. However, these findings are based on cohorts followed nearly 20 years ago.…”

mentioning

confidence: 99%

Patterns of sensitization to food and aeroallergens in the first 3 years of life

Dean

Venter

Pereira

et al. 2007

Journal of Allergy and Clinical Immunology

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“…The risk of allergy onset was conferred solely to the latter. It can be speculated that the former represents a state of transient SPT sensitisation [33,34] or a very early condition that over time progresses to increased allergen susceptibility. Could this be represented by the few subjects with insignificant symptoms?…”

Section: Discussionmentioning

confidence: 99%

A Prospective, Clinical Study on Asymptomatic Sensitisation and Development of Allergic Rhinitis: High Negative Predictive Value of Allergological Testing

Bødtger¹,

Assing²,

Poulsen³

2011

Int Arch Allergy Immunol

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Background: Asymptomatic aeroallergen sensitisation affects approximately 10% of Western adolescents and is an established risk factor for the development of respiratory allergy. The reported incidence is 2–20% annually. Previous studies are based on out-seasonal symptom recollection or selected populations, conferring bias towards higher incidence rates. Objective: The aim was to determine the incidence of onset of symptoms among clinically well-characterised asymptomatic, sensitised subjects compared with controls, and to evaluate the predictive values of common allergological tests. Methods: We performed a prospective, clinical, non-interventional, 2-year follow-up study on subjects (identified by population screening) with seasonal allergic birch or grass pollen rhinitis (n = 52), asymptomatic sensitisation to grass or birch (AS, n = 52) or non-atopic, healthy control subjects (n = 39). Experimental allergen susceptibility was assessed at inclusion and at follow-up by skin prick test, conjunctival challenge, intradermal late-phase reaction and measurement of specific IgE. Participants completed in-seasonal symptom and medication diaries during 2 subsequent seasons. Results: We observed an annual incidence rate of 5% for the onset of symptoms in the AS group (healthy control group 0%). At baseline, the AS group displayed intermediate experimental allergen susceptibility. Subjects developing symptoms had higher levels of specific IgE and larger late-phase reaction than those persistently asymptomatic. However, the positive predictive values were low (14–27%) in contrast to the negative predictive values (95–100%). Conclusion: In a well-characterised young population, asymptomatic aeroallergen sensitisation conferred a low risk for onset of symptoms during the 2-year follow-up. Persistent asymptomatic phenotype could be accurately predicted by negative results from simple allergological testing.

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“…The cut-off point for a positive test was 1.43 Magic-Lite (ML) units [16]. Measurement of total serum IgE was carried out by an enzyme allergosorbent test (Phadezym; Pharmacia, Uppsala, Sweden).…”

Section: Methodsmentioning

confidence: 99%

Association of Uteroglobulin-Related Protein 1 with Bronchial Asthma

Heinzmann

Dietrich

Deichmann

2003

Int Arch Allergy Immunol

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Background: Chromosomal region 5q31 harbours a number of genes associated with atopic phenotypes, for example the genes coding for interleukin (IL) 4, IL13 and the β₂-adrenoreceptor. A new gene within this region was identified only very recently. The encoded protein – uteroglobin-related protein 1 (UGRP1) – is thought to act as an anti-inflammatory agent and is mainly expressed in the lung and trachea. The functional promoter polymorphism A-112G in UGRP1 was shown to be associated with bronchial asthma in a Japanese population. We were thus interested in finding out whether the polymorphism so far identified or others within UGRP1 were associated with bronchial asthma in a German Caucasian population. Methods: We performed direct genomic sequencing of the promoter and coding region of UGRP1 in 15 asthmatic children and 15 controls. The identified polymorphisms were genotyped by means of RFLP. Statistical analysis was performed with the Armitage trend test. Results: We identified 5 non-coding variants, 4 of which being described for the first time. Three polymorphisms were common and typed in 182 asthmatic children and 270 controls. None of the polymorphisms were associated with bronchial asthma in our population. Conclusions: We conclude from our data that UGRP1 does not play a major role in the development of bronchial asthma in our Caucasian population.

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Longitudinal variability of skin prick test results

Cited by 42 publications

References 17 publications

Patterns of sensitization to food and aeroallergens in the first 3 years of life

Patterns of sensitization to food and aeroallergens in the first 3 years of life

A Prospective, Clinical Study on Asymptomatic Sensitisation and Development of Allergic Rhinitis: High Negative Predictive Value of Allergological Testing

Association of Uteroglobulin-Related Protein 1 with Bronchial Asthma

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