Longitudinal urinary metabolomic profiling reveals metabolites for asthma development in early childhood

Chiu, Chih‐Yung; Lin, Gigin; Cheng, Mei‐Ling; Chiang, Meng-Han; Tsai, Ming‐Han; Su, Kuan‐Wen; Hua, Mau‐Sun; Liao, Sui‐Ling; Lai, Shen‐Hao; Yao, Tsung‐Chieh; Yeh, Kuo‐Wei; Huang, Jing‐Long

doi:10.1111/pai.12909

Cited by 38 publications

(46 citation statements)

References 31 publications

(36 reference statements)

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“…Metabolomics profiling and analysis of urine samples have successfully identified microbial-derived metabolites associated with asthma development [25]. In this study, urine TMAO, a dietary compound produced by bacteria in the intestine [26], was identified to be associated with food sensitization and childhood asthma.…”

Section: Discussionmentioning

confidence: 95%

Metabolomic Analysis Reveals Distinct Profiles in the Plasma and Urine Associated with IgE Reactions in Childhood Asthma

Chiu

Cheng

Chiang

et al. 2020

JCM

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Several metabolomics studies have identified altered metabolic pathways that are related to asthma. However, an integrative analysis of the metabolic responses across blood and urine for a comprehensive framework of asthma in early childhood remains lacking. Fifty-four age-matched children with asthma (n = 28) and healthy controls (n = 26) were enrolled. Metabolome analysis of the plasma and urine samples was performed using 1H-nuclear magnetic resonance (NMR) spectroscopy coupled with partial least-squares discriminant analysis (PLS-DA). Integrated analysis of blood and urine metabolic profiling related to IgE reactions for childhood asthma was investigated. A significantly higher plasma histidine level was found, in parallel with lower urinary 1-methylnicotinamide and trimethylamine N-oxide (TMAO) levels, in children with asthma compared to healthy controls. Compared to children without allergic sensitization, 11 (92%) plasma metabolites and 8 (80%) urinary metabolites were found to be significantly different in children with IgE and food sensitization respectively. There were significant correlations between the plasma 3-hydroxybutyric acid and excreted volumes of the hydroxy acids, which were strongly correlated to plasma leucine and valine levels. Urine N-phenylacetylglycine, a microbial-host co-metabolite, was strongly correlated with total serum and food allergen-specific IgE levels. Plasma pyruvate and urine valine, leucine, and isoleucine degradation metabolisms were significantly associated with allergic sensitization for childhood asthma. In conclusion, blood and urine metabolome reflect different metabolic pathways in allergic reactions. Plasma pyruvate metabolism to acetic acid appears to be associated with serum IgE production, whereas urine branched-chain amino acid metabolism primarily reflects food allergic reactions against allergies.

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Section: Discussionmentioning

confidence: 95%

Metabolomic Analysis Reveals Distinct Profiles in the Plasma and Urine Associated with IgE Reactions in Childhood Asthma

Chiu

Cheng

Chiang

et al. 2020

JCM

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“…The first study commented here comes from Taiwan, by Chih-Yung Chiu et al 2 This group of researchers is much interested in the metabolic signatures of allergy, and they have recently published on urinary metabolic components in asthma. 3 In the current study, they measured various metabolites in the feces of asthmatic children and correlated their levels with the gut bacterial community signature revealed by 16S rRNA. They showed that the amino acid metabolism was inversely correlated to the abundance of the phylum Firmicutes.…”

Section: Fecal Metabolites and Early Sensitization Influence Asthma mentioning

confidence: 99%

Fecal metabolites and early sensitization influence asthma, and how to prevent anaphylaxis in the community

Eigenmann

2019

Pediatric Allergy Immunology

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“…57 Dimethylamine and allantoin are gut microbial-derived metabolites that have been associated with asthma development in early childhood and are potential prognostic markers of asthma. 58 A comprehensive systematic review and meta-analysis has recently reviewed bronchial hyperresponsiveness (BHR) in preterm-born subjects. 59 Bronchial provocation tests to methacholine and exercise indicated that preterm-born individuals had greater BHR compared with term-born, particularly those with chronic lung disease.…”

Section: Pred Ic Ti On and Pre Venti On Of Allerg I C D Is E A S Ementioning

confidence: 99%

Highlights and recent developments in airway diseases in EAACI journals (2018)

Bousquet

Akdiş

Grattan

et al. 2019

Allergy

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The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Pediatric Allergy and Immunology, and Clinical and Translational Allergy. EAACI's major goals include supporting the promotion of health, in which the prevention of allergy and asthma plays a critical role, and disseminating the knowledge of allergic disease to all stakeholders. In 2018, the remarkable progress in the identification of basic mechanisms of allergic and respiratory diseases as well as the translation of these findings into clinical practice were observed. Last year's highlights include publication of EAACI guidelines for allergen immunotherapy, many EAACI Position Papers covering important aspects for the specialty, better understanding of molecular and cellular mechanisms, identification of biomarkers for disease prediction and progress monitoring, novel prevention and intervention studies, elucidation of mechanisms of multimorbidities, introduction of new drugs to the clinics, recently completed phase three clinical studies, and publication of a large number of allergen immunotherapy studies and meta‐analyses.

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Longitudinal urinary metabolomic profiling reveals metabolites for asthma development in early childhood

Cited by 38 publications

References 31 publications

Metabolomic Analysis Reveals Distinct Profiles in the Plasma and Urine Associated with IgE Reactions in Childhood Asthma

Metabolomic Analysis Reveals Distinct Profiles in the Plasma and Urine Associated with IgE Reactions in Childhood Asthma

Fecal metabolites and early sensitization influence asthma, and how to prevent anaphylaxis in the community

Highlights and recent developments in airway diseases in EAACI journals (2018)

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