Longitudinal trends of per- and polyfluoroalkyl substances in children's serum

Koponen, Jani; Winkens, Kerstin; Airaksinen, Riikka; Berger, Urs; Vestergren, Robin; Cousins, Ian T.; Karvonen, Anne M.; Pekkanen, Juha; Kiviranta, Hannu

doi:10.1016/j.envint.2018.09.006

Cited by 47 publications

(26 citation statements)

References 72 publications

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“…the total amount of a pollutant in an organism) of PFOA decreased with age in the females, whereas it increased with age in the males. 20 It can be seen that the model is in better agreement with the measured serum concentrations when the median serum concentrations at 6 and 10.5 years of age were reconstructed in comparison to the modelled serum concentrations of each individual (Table 4 and Fig. S4 ‡).…”

Section: Dynamic Modellingmentioning

confidence: 85%

“…It was not possible to reconstruct the observed sex-specic trends in PFOA and PFOS serum concentrations that were found among the children of the cohort. 20 The median body burden (i.e. the total amount of a pollutant in an organism) of PFOA decreased with age in the females, whereas it increased with age in the males.…”

Section: Dynamic Modellingmentioning

confidence: 97%

“…For the current modelling approach, serum, 20 indoor air, 21 dust 22 and tap water concentrations (unpublished data) of PFASs from a child cohort study were used. The serum concentrations of PFOA, PFOS and PFHxS were analysed for each of the 44 children at the age of 1 year (2005/6), 6 years (2010/11) and 10.5 years (2014/15).…”

Section: The Child Cohort and Datamentioning

confidence: 99%

“…The serum concentrations of PFOA, PFOS and PFHxS were analysed for each of the 44 children at the age of 1 year (2005/6), 6 years (2010/11) and 10.5 years (2014/15). 20 The children were a subgroup of a longitudinal child study (LUKAS 2) from the Kuopio area in Finland. 19 Within LUKAS 2, the individuals' body weights were documented as well.…”

Section: The Child Cohort and Datamentioning

confidence: 99%

See 3 more Smart Citations

Children's exposure to perfluoroalkyl acids – a modelling approach

Balk

Pütz

Ribbenstedt

et al. 2019

Environ. Sci.: Processes Impacts

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Section: Dynamic Modellingmentioning

confidence: 85%

Section: Dynamic Modellingmentioning

confidence: 97%

Section: The Child Cohort and Datamentioning

confidence: 99%

Section: The Child Cohort and Datamentioning

confidence: 99%

See 2 more Smart Citations

Children's exposure to perfluoroalkyl acids – a modelling approach

Balk

Pütz

Ribbenstedt

et al. 2019

Environ. Sci.: Processes Impacts

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“…Of additional concern, an examination of these compounds in U.S. children 3-11 years of age, most of whom were born after PFOS and PFOA were phased out of use, revealed detectable levels of 14 PFAS, including PFOS and PFOA, in more than 60% of study subjects (Ye et al 2018). A longitudinal study in Finnish children and adolescents showed that although serum levels of PFOS, PFOA, perfluorohexanesulfonic acid (PFHxS), and perfluorohexanoic acid (PFHxA) decreased over the study period, calculated body burdens generally remained constant and, in some cases, increased (Koponen et al 2018). In humans, PFAS exposure has been associated with reduced birth weight (Apelberg et al 2007;Fei et al 2007), although weak associations with low birth weight or conflicting data have also been reported (Manzano-Salgado et al 2017;Shoaff et al 2018;Whitworth et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Developmental Toxicity, Developmental Neurotoxicity, and Tissue Dose in Zebrafish Exposed to GenX and Other PFAS

Gaballah

Swank

Sobus

et al. 2020

Environ Health Perspect

258

149

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BACKGROUND: Per-and polyfluoroalkyl substances (PFAS) are a diverse class of industrial chemicals with widespread environmental occurrence. Exposure to long-chain PFAS is associated with developmental toxicity, prompting their replacement with short-chain and fluoroether compounds. There is growing public concern over the safety of replacement PFAS. OBJECTIVE: We aimed to group PFAS based on shared toxicity phenotypes. METHODS: Zebrafish were developmentally exposed to 4,8-dioxa-3H-perfluorononanoate (ADONA), perfluoro-2-propoxypropanoic acid (GenX Free Acid), perfluoro-3,6-dioxa-4-methyl-7-octene-1-sulfonic acid (PFESA1), perfluorohexanesulfonic acid (PFHxS), perfluorohexanoic acid (PFHxA), perfluoro-n-octanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), or 0.4% dimethyl sulfoxide (DMSO) daily from 0-5 d post fertilization (dpf). At 6 dpf, developmental toxicity and developmental neurotoxicity assays were performed, and targeted analytical chemistry was used to measure media and tissue doses. To test whether aliphatic sulfonic acid PFAS cause the same toxicity phenotypes, perfluorobutanesulfonic acid (PFBS; 4-carbon), perfluoropentanesulfonic acid (PFPeS; 5-carbon), PFHxS (6-carbon), perfluoroheptanesulfonic acid (PFHpS; 7-carbon), and PFOS (8-carbon) were evaluated. RESULTS: PFHxS or PFOS exposure caused failed swim bladder inflation, abnormal ventroflexion of the tail, and hyperactivity at nonteratogenic concentrations. Exposure to PFHxA resulted in a unique hyperactivity signature. ADONA, PFESA1, or PFOA exposure resulted in detectable levels of parent compound in larval tissue but yielded negative toxicity results. GenX was unstable in DMSO, but stable and negative for toxicity when diluted in deionized water. Exposure to PFPeS, PFHxS, PFHpS, or PFOS resulted in a shared toxicity phenotype characterized by body axis and swim bladder defects and hyperactivity. CONCLUSIONS: All emerging fluoroether PFAS tested were negative for evaluated outcomes. Two unique toxicity signatures were identified arising from structurally dissimilar PFAS. Among sulfonic acid aliphatic PFAS, chemical potencies were correlated with increasing carbon chain length for developmental neurotoxicity, but not developmental toxicity. This study identified relationships between chemical structures and in vivo phenotypes that may arise from shared mechanisms of PFAS toxicity. These data suggest that developmental neurotoxicity is an important end point to consider for this class of widely occurring environmental chemicals.

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Rapid biomonitoring of perfluoroalkyl substance exposures in serum by multisegment injection‐nonaqueous capillary electrophoresis‐tandem mass spectrometry

Hum

Britz‐McKibbin

2020

Analytical Science Advances

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Perfluoroalkyl substances (PFASs) are a major contaminant class due to their ubiquitous prevalence, persistence, and putative endocrine disrupting activity that may contribute to chronic disease risk notably with exposures early in life. Herein, multisegment injection-nonaqueous capillary electrophoresis-tandem mass spectrometry (MSI-NACE-MS/MS) is introduced as a high throughput approach for PFAS screening in serum samples following a simple methyl-tert-butyl ether (MTBE) liquid extraction. Separation and ionization conditions were optimized to quantify low nanomolar concentration levels of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) from serum extracts when using multiple reaction monitoring under negative ion mode conditions. Multiplexed separations of PFOA and PFOS were achieved with excellent throughput (<3 min/sample), adequate concentration sensitivity (LOD ∼ 20 nM, S/N = 3) and good technical precision over three consecutive days of analysis (mean CV = 9.1%, n = 84). Accurate quantification of PFASs was demonstrated in maternal serum samples (n = 16) when using MSI-CE-MS/MS following pre-column sample enrichment with median concentrations of 3.46 nM (0.7-9.0 nM) and 3.29 nM (1.5-6.6 nM) for PFOA and PFOS, respectively. This was lower than average PFAS exposures measured in pregnant women who had serum collected prior to 2009 likely due to subsequent phase out of their production. Overall, this method offers a convenient approach for large-scale biomonitoring of environmental exposures to legacy PFASs and their emerging replacements that is relevant to maternal health and chronic disease risk assessment in children.

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Longitudinal trends of per- and polyfluoroalkyl substances in children's serum

Cited by 47 publications

References 72 publications

Children's exposure to perfluoroalkyl acids – a modelling approach

Children's exposure to perfluoroalkyl acids – a modelling approach

Evaluation of Developmental Toxicity, Developmental Neurotoxicity, and Tissue Dose in Zebrafish Exposed to GenX and Other PFAS

Rapid biomonitoring of perfluoroalkyl substance exposures in serum by multisegment injection‐nonaqueous capillary electrophoresis‐tandem mass spectrometry

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