Longitudinal Trajectories of Depression and Anxiety in a Prospective Community Study

"Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11." Psychological Medicine.39,12. 2043-2059. http://digitalcommons.wustl.edu/open_access_pubs/3923Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11Paper 5 of 7 of the thematic section : ' A proposal for a meta-structure for DSM-V and ICD-11 ' Background. The extant major psychiatric classifications DSM-IV, and ICD-10, are atheoretical and largely descriptive. Although this achieves good reliability, the validity of a medical diagnosis would be greatly enhanced by an understanding of risk factors and clinical manifestations. In an effort to group mental disorders on the basis of aetiology, five clusters have been proposed. This paper considers the validity of the fourth cluster, emotional disorders, within that proposal.Method. We reviewed the literature in relation to 11 validating criteria proposed by a Study Group of the DSM-V Task Force, as applied to the cluster of emotional disorders.Results. An emotional cluster of disorders identified using the 11 validators is feasible. Negative affectivity is the defining feature of the emotional cluster. Although there are differences between disorders in the remaining validating criteria, there are similarities that support the feasibility of an emotional cluster. Strong intra-cluster co-morbidity may reflect the action of common risk factors and also shared higher-order symptom dimensions in these emotional disorders.Conclusion. Emotional disorders meet many of the salient criteria proposed by the Study Group of the DSM-V Task Force to suggest a classification cluster.

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“…disorder alone, and particularly anxiety, is far lower than that of co-morbidity (Merikangas et al 2003).…”

Section: Coursementioning

confidence: 86%

Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11

et al. 2009

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“…A significant comorbidity of substance use with affective disorder, especially bipolar disorder, and schizophrenia is well established (Kessler et al 2005;Marmorstein et al 2010;Merikangas et al 2003). More recently, comorbidity with anxiety disorders has emerged as a focus (Grant et al 2009).…”

Section: Definition Of Anxiety Disordersmentioning

confidence: 99%

Comorbidity of Anxiety Disorders and Substance Use

Soyka

2014

Co-Occurring Addictive and Psychiatric Disorders

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“…The most prevalent comorbidities are anxiety disorders,8 substance use disorders9 and other depressive disorders. Epidemiologic studies have shown that the prevalence of at least one lifetime anxiety disorder was 59% in patients with lifetime MDD,10 while the prevalence of substance use disorders in MDD was 14% 9.…”

Section: Introductionmentioning

confidence: 99%

Psychiatric comorbidities in patients with major depressive disorder

Thaipisuttikul¹,

Ittasakul²,

Waleeprakhon³

et al. 2014

NDT

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BackgroundPsychiatric comorbidities are common in major depressive disorder (MDD). They may worsen outcome and cause economic burden. The primary objective was to examine the prevalence of psychiatric comorbidities in MDD. The secondary objectives were to compare the presence of comorbidities between currently active and past MDD, and between patients with and without suicidal risk.MethodsThis was a cross-sectional study. A total of 250 patients with lifetime MDD and age ≥18 years were enrolled. The Mini International Neuropsychiatric Interview (MINI), Thai version, was used to confirm MDD diagnosis and classify comorbidities. MDD diagnosis was confirmed in 190, and 60 patients were excluded due to diagnosis of bipolar disorder.ResultsOf the 190 MDD patients, 25.8% had current MDD and 74.2% had past MDD. Eighty percent were women. The mean age at enrollment was 50 years, and at MDD onset was 41 years. Most patients were married (53.2%), employed (54.8%), and had ≥12 years of education (66.9%). There were 67 patients (35.3%) with one or more psychiatric comorbidities. Comorbidities included dysthymia (19.5%), any anxiety disorders (21.1%) (panic disorder [6.8%], agoraphobia [5.8%], social phobia [3.7%], obsessive–compulsive disorder [OCD] [4.7%], generalized anxiety disorder [5.3%], and post-traumatic stress disorder [4.2%]), alcohol dependence (0.5%), psychotic disorder (1.6%), antisocial personality (1.1%), and eating disorders (0%). Compared with past MDD, the current MDD group had significantly higher OCD (P<0.001), psychotic disorder (P=0.048), past panic disorder (P=0.017), and suicidal risk (P<0.001). Suicidal risk was found in 32.1% of patients. Patients with suicidal risk had more comorbid anxiety disorder of any type (P=0.019) and psychotic disorder (P=0.032).ConclusionSeveral comorbidities were associated with MDD. Patients with active MDD had higher comorbid OCD, psychotic disorder, past panic disorder, and suicidal risk. Patients with suicide risk had higher comorbid anxiety and psychotic disorders.

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Longitudinal Trajectories of Depression and Anxiety in a Prospective Community Study

Cited by 347 publications

References 60 publications

Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11

Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11

Comorbidity of Anxiety Disorders and Substance Use

Psychiatric comorbidities in patients with major depressive disorder

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