Longitudinal trajectories of Alzheimer's disease CSF biomarkers and blood pressure in cognitively healthy subjects
Adrienne Biskaduros,
Lidia Glodzik,
Leslie A. Saint Louis
et al.
Abstract:INTRODUCTIONWe examined whether hypertension (HTN) was associated with Alzheimer's disease‐related biomarkers in cerebrospinal fluid (CSF) and how changes in blood pressure (BP) related to changes in CSF biomarkers over time.METHODSA longitudinal observation of cognitively healthy normotensive subjects (n = 134, BP < 140/90, with no antihypertensive medication), controlled HTN (n = 36, BP < 140/90, taking antihypertensive medication), and 35 subjects with uncontrolled HTN (BP ≥ 140/90). The follow‐up ran… Show more
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