Longitudinal Study of Radiographic Spinal Osteoarthritis in a Macaque Model

Duncan, Andrea E.; Colman, Ricki J.; Kramer, Patricia Ann

doi:10.1002/jor.21390

Cited by 16 publications

(14 citation statements)

References 33 publications

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“…The life cycle of macaques is the same as that of humans (Hamada and Yamamoto, 2010), including the elderly stage. In general, macaques age at a rate of 2.5-3.5 times that of humans (Colman and Anderson, 2011;Duncan et al, 2011). Although a good model of human aging, macaques have not been well studied in terms of the effect of aging on the skull.…”

Section: Introductionmentioning

confidence: 99%

Aging-related changes in the skulls of Japanese macaques (<i>Macaca fuscata</i>)

Minh

Mouri

Hamada

2015

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We investigated aging-related changes in the skulls of Japanese macaques (Macaca fuscata). A total of 145 (70 males, 75 females) skulls from macaques aged 7.0-26.9 years (males) and 7.0-30.7 years (females) were measured for 22 craniometric items. Some skull dimensions increased from young adulthood (7.0 years) to the peak at 13.3-19.0 years in males and at 19.7-22.6 years in females. Some dimensions remained at their peak value right through into very old age whereas others continued increasing during this stage of life. Continued increase of cranial size in adulthood has been also observed in humans, but the magnitude of change was greater in macaques. Facial and mandibular dimensions showed larger and more significant increases than neurocranial dimensions in macaques, as in humans, including facial height, bizygomatic breadth, mandibular body height, and ramus breadth in both sexes. Intertemporal distance and biorbital breadths after 16.0 years of age decreased significantly in males, and cranial and posterior basicranial lengths increased only in males. We suggest that these craniometric changes are associated with the development of the insertion area onto which muscles attach (by accumulation of physical stress). The face and mandible are greatly influenced by tooth loss and/or dental disorders, both of which are evident in humans. In the present study large changes were also found in skulls that had lost several teeth.

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Section: Introductionmentioning

confidence: 99%

Aging-related changes in the skulls of Japanese macaques (<i>Macaca fuscata</i>)

Minh

Mouri

Hamada

2015

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“…This group is second only to non-human apes in phylogenetic proximity to humans, and, consequently, shares with us many aspects of skeletal anatomy, genetics, and disease 12-14 . Rhesus ( Macaca mulatta ) and cynomolgus macaques ( Macaca fascicularis ) have also been extensively studied with regard to OA 9-11,15-24 . We summarize general results in these species and in baboons in Table 1.…”

Section: Introductionmentioning

confidence: 99%

Reproductive status and sex show strong effects on knee OA in a baboon model

Macrini

Coan

Levine

et al. 2013

Osteoarthritis and Cartilage

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Objective We aimed to characterize severity and occurrence of knee osteoarthritis (OA), and effects of age, sex, body weight, and reproductive status on population-level normal variation in this condition in the baboon, a natural model of human knee OA. Methods We visually inspected articular cartilage of distal right femora of 464 baboons (309 females, 155 males) and assigned an OA severity score (comparable to a modified Outerbridge score) from 1 = unaffected to 4 = advanced OA (eburnation). Presence/absence of osteophytes was recorded. We tested for significant effects of age, sex, weight, and, in females, reproductive status (pre-, peri-, or post-menopausal) on OA. When appropriate, analyses were repeated on an age-matched subset (153 of each sex). Results Knee OA was more frequent and severe in older animals (p < 0.0001), but significant age variation was apparent in each severity grade. Sex differences within the younger and older age groups suggest that males develop knee OA earlier, but females progress more quickly to advanced disease. There is a strong relationship between reproductive status and OA severity grade in females (p = 0.0005) with more severe OA in peri- and post-menopausal female baboons, as in humans. Conclusions Idiopathic knee OA is common in adult baboons. Occurrence and severity are influenced strongly by reproductive status in females, and by sex with regard to patterns of disease progression – providing an animal model to investigate sex-specific variation in OA susceptibility in which the environmental heterogeneity inherent in human populations is vastly reduced.

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“…Rhesus monkeys ( Macaca mulatta ) have been proposed as a potential animal model for studying the etiology of disc degeneration and spinal OA, because they are known to have naturally-occurring degenerating intervertebral discs with advancing age 13,14,22 . In the present study, moreover, we found that spinal OA and disc degeneration among aged rhesus monkeys demonstrate comparable histologic pathologies as those that occur with advancing disc degeneration in humans as reported by Thompson 17 .…”

Section: Discussionmentioning

confidence: 99%

Comparison of vertebral and intervertebral disc lesions in aging humans and rhesus monkeys

Bailey

Fields

Liebenberg

et al. 2014

Osteoarthritis and Cartilage

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Objective To compare gross and histologic patterns of age-related degeneration within the intervertebral disc and adjacent vertebra between rhesus monkeys and humans. Materials and methods We examined age-related patterns of disc degeneration from mid-sagittal sections of the intervertebral disc and adjacent vertebral bodies among six rhesus monkey thoracolumbar and seven human lumbar spines. Gross morphology and histopathology were assessed via the Thompson grading scheme and other degenerative features of the disc and adjacent bone. Results Thompson grades ranged from 3 through 5 for rhesus monkey discs (T9-L1) and 2 through 5 for the human discs (T12-S1). In both rhesus monkey and human discs, presence of distinct lesions were positively associated with Thompson grade of the overall segment. Degenerative patterns differed for radial tears, which were more prevalent with advanced disc degeneration in humans only. Additionally, compared to the more uniform anteroposterior disc degeneration patterns of humans, rhesus monkeys showed more severe osteophytosis and degeneration on the anterior border of the vertebral column. Conclusions Rhesus monkey spines evaluated in the present study appear to develop age-related patterns of disc degeneration similar to humans. One exception is the absence of an association between radial tears and disc degeneration, which could reflect species-specific differences in posture and spinal curvature. Considering rhesus monkeys demonstrate similar patterns of disc degeneration, and age at a faster rate than humans, these findings suggest longitudinal studies of rhesus monkeys may be a valuable model for better understanding the progression of human age-related spinal osteoarthritis and disc degeneration.

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Longitudinal Study of Radiographic Spinal Osteoarthritis in a Macaque Model

Cited by 16 publications

References 33 publications

Aging-related changes in the skulls of Japanese macaques (<i>Macaca fuscata</i>)

Aging-related changes in the skulls of Japanese macaques (<i>Macaca fuscata</i>)

Reproductive status and sex show strong effects on knee OA in a baboon model

Comparison of vertebral and intervertebral disc lesions in aging humans and rhesus monkeys

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