Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of pre‐eclampsia

Dündar, Özgür; Yörük, Pınar; Tütüncü, Levent; Erikçi, Alev Akyol; Muhçu, Murat; Ergür, Ali Rüştü; Atay, Vedat; Müngen, Ercüment

doi:10.1002/pd.2126

Cited by 107 publications

(128 citation statements)

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“…Despite previous studies showing an association between hematological parameters and PE, the relationship between the severity of hypertension and hematologic parameters in preeclamptic women has not been thoroughly studied (7,8) . This study was undertaken to investigate the relationship between the severity of hypertension (HT) and hematologic parameters in preeclamptic women that can be measured by a simple complete blood count.…”

Section: Introductionmentioning

confidence: 99%

Mean Platelet Volume and Neutrophil Lymphocyte Ratio as New Markers of Preeclampsia Severity

Akıl¹

2015

Kosuyolu Heart Journal

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Introduction: This study was undertaken to examine the role of hematological parameters in predicting the severity of hypertension in pre-eclamptic women. Patients and Methods:Two hundred sixty-one pre-eclamptic women and fi fty-one women with normal pregnancy were included in the study. The severity of preeclampsia was classifi ed as mild or severe.Results: Compared to post-delivery period, pre-eclamptic females had lower platelet count, raised mean platelet volume and raised neutrophil lymphocyte ratio (p< 0.001, p< 0.001, p< 0.001, respectively). Multiple linear regression analysis showed an independent correlation between the severity of hypertension and mean platelet volume as well as the neutrophil lymphocyte ratio (β= 0.25, p< 0.001; β= 0.31, p< 0.001, respectively). Conclusion:Both mean platelet volume and neutrophil lymphocyte ratio emerged as independent predictors of the severity of hypertension in preeclampsia.

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Section: Introductionmentioning

confidence: 99%

Mean Platelet Volume and Neutrophil Lymphocyte Ratio as New Markers of Preeclampsia Severity

Akıl¹

2015

Kosuyolu Heart Journal

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“…Although MPV should be measured by clinical hematology analysts using sodium citrate, MPV is usually measured as a component of a complete blood count within ethylenediaminetetraacetic acid (EDTA) tubes in routine clinical practice. Since the anticoagulant EDTA induces the platelet shape to change, MPV increases in a time-dependent manner, and the measurements become relatively unreliable [22]. Additionally, one of the other major most important limitations of the study is the difficulty to rule out endometriosis which was the leading cause of secondary dysmenorrhea.…”

Section: Discussionmentioning

confidence: 99%

Considerations on pathophysiology of primary dysmenorrhea under the light of alterations in complete blood count parameters

Bodur¹,

Pektaş²,

Bakir³

et al. 2017

Med-Science

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The present study strives to evaluate how the components of complete blood count are altered in women with primary dysmenorrhea. This is a cross-sectional analysis of 155 women with primary dysmenorrhea and 155 women without dysmenorrhea. The primary dysmenorrhea and control groups were matched with respect to age and body mass index. When compared with the controls, the women with primary dysmenorrhea had a significantly younger menarche age, longer menstrual duration, higher leukocyte counts, higher neutrophil counts, and elevated MPV values (p=0.010, p=0.022, p=0.014, p=0.011 and p=0.04 respectively). The logistic regression analysis demonstrated that women with primary dysmenorrhea were more likely to have a younger menarche age (OR=2.14, 95% CI=0.971-3.346, p=0.018), longer menstrual duration (OR=1.91, 95% CI=0.988-2.308, p=0.044), higher leukocyte counts (OR= 2.90, 95% CI=1.040-3.788, p=0.007), and elevated MPV values (OR=3.17, 95% CI=2.056-9.128, p=0.001). The sensitivity and specificity of this model were 84.6% and 77.3%, respectively. Leukocytosis and increased MPV are might be associated with the inflammatory and vasoconstrictory pathogenesis of primary dysmenorrhea, but this result should be confirmed in the future researches.

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“…Some researchers found no change in the values of these indices between patients and controls (Ceyhan, 2006, Freitas, 2013. Whereas others demonstrated difference in platelet index values (Yong, 2014;Dundar, 2008). This consistency of those studies may be due to the varying methods of platelet indices determination (Ceyhan, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…The validity of alteration in the MPV in predicting preeclampsia has been extensively analyzed (Dundar et al, 2008). Many studies concluded that pregnant women with medical disorders with > MPV had an increased risk for developing pre-eclampsia (Jarmo et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Thrombocytopenia is generally common in pregnant women compared to nonpregnant women. Rarely, become lethal and increased the mortality (Dundar, 2008). The platelet indices, plateletcrit, mean platelet volume, platelet distribution width, platelet large cell ratio, and platelet large cell concentration are a group of platelet parameters related to platelet morphology and proliferation kinetics (Budak, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Platelet Indices among Sudanese Pregnant Women with Medical Disorders Association; A Cross-sectional Study in Port Sudan City

Mohammed¹,

Dirar²,

Badaneen³

2017

ijSciences

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Abstract:Pregnant women with medical disorders may associated with multiple changes in platelet indices parameters. It may be arising from hemodilution or increased platelet consumption during uteroplacental circulation. Platelet indices (PI) are a group of derived platelet parameters extracted as a part of the automatic complete hemogram. This study aimed to investigate the potential role of Platelets as a diagnostic or prognostic marker across the disease associated with Sudanese pregnancies. A cross-sectional study was conducted in March 2015 at Port Sudan Teaching Hospital, Port Sudan, Sudan. 40 Sudanese pregnant women with different medical complications were enrolled and 10 well pregnant women were included in this study. In both, platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), platelet large cell ratio (P-LCR) and platelet cell concentration (P-LCC) were done. The pregnant women with medical association in compared with well pregnant women were found to be significant in the MPV, PDW, P-LCR, and P-LCC (P < 0.022, 0.036, 0.021 and 0.040 respectively). In contrast, PLT and PCT were found to be insignificant (P< 0.871 and 0.666). However, platelet indices were higher in patients than in controls except for the PLT and PCT level no changes were displayed. Accordingly, the convincing laboratory evidences in this study show that the usefulness of platelet indices as marker for medical disorders associated with pregnancy. The MPV and PDW are potential markers in the predicting disease severity.

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Longitudinal study of platelet size changes in gestation and predictive power of elevated MPV in development of pre‐eclampsia

Abstract: Our study provides evidence that MPV gradually increases in pregnant women affected by pre-eclampsia compared to women with normal pregnancies.

Cited by 107 publications

References 25 publications

Mean Platelet Volume and Neutrophil Lymphocyte Ratio as New Markers of Preeclampsia Severity

Mean Platelet Volume and Neutrophil Lymphocyte Ratio as New Markers of Preeclampsia Severity

Considerations on pathophysiology of primary dysmenorrhea under the light of alterations in complete blood count parameters

Platelet Indices among Sudanese Pregnant Women with Medical Disorders Association; A Cross-sectional Study in Port Sudan City

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