Longitudinal study of pesticide residue levels in human milk from Western Australia during 12 months of lactation: Exposure assessment for infants

Du, Jian; Gridneva, Zoya; Gay, Melvin; Lai, Ching Tat; Trengove, Robert D.; Hartmann, Peter; Geddes, Donna T.

doi:10.1038/srep38355

Cited by 20 publications

(21 citation statements)

References 66 publications

(84 reference statements)

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“…p,p'-DDT and its metabolites, such as p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), are widespread in the environment [2]. Both of these chemicals have been measured in human samples like breast milk [3][4][5][6].…”

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confidence: 99%

“…Because most epidemiologic studies on the association of p,p'-DDT and p,p'-DDE with children's weight focused on prenatal exposure, little is known about the potential impacts of exposure through breast milk. We only identified three studies on lactational exposure to p, p'-DDE and children's weight [3,16,17]. Two out of three studies used approaches that do not account for the complexity of early-life pharmacokinetics, which are influenced by many factors such as child growth, breast milk content, and breastfeeding duration.…”

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confidence: 99%

“…Two out of three studies used approaches that do not account for the complexity of early-life pharmacokinetics, which are influenced by many factors such as child growth, breast milk content, and breastfeeding duration. Du et al [3] used breast milk levels at 2, 5, 9 and 12 months in 16 mothers to estimate children's exposure. They found no association between breast milk levels and infant growth and development measures at 12 months of age.…”

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confidence: 99%

“…They found no association between lactational exposure and infant growth at 12 months of age. As an alternative approach to assess lactational exposure, toxicokinetic modeling can be used to estimate children's levels during and after lactation, overcoming the methodological limits of the Du et al [3] and Pan et al [16] studies. Such models have been developed [18][19][20][21] to estimate children's levels during infancy/childhood, allowing the assessment of associations between exposure during hypothesized windows of vulnerability and various health outcomes.…”

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confidence: 99%

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Estimated postnatal p,p’-DDT and p,p’-DDE levels and body mass index at 42 months of age in a longitudinal study of Japanese children

et al. 2020

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Background: Children are exposed to p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT) and p,p'dichlorodiphenyldichloroethylene (p,p'-DDE) through placental and lactational transfer. Some studies have suggested that early-life exposure to these compounds could lead to increased body mass index (BMI) during childhood. Our aim was to assess whether children's exposure during the first 2 years of life is associated with BMI z-score in Japanese children at 42 months of age. Methods: We used data from a birth cohort (n = 290) of the Tohoku Study of Child Development. p,p'-DDT and p, p'-DDE levels were measured in breast milk samples collected 1 month after birth, and levels in children were estimated using a toxicokinetic model for three exposure periods (0-6 months, 6-12 months, 12-24 months). Associations between exposure estimates and BMI z-score at 42 months of age were assessed using multivariate linear regression models. Results: We found no significant association between levels of p,p'-DDT measured in breast milk or estimated in children and BMI z-score. However, we observed associations between estimated p,p'-DDE levels in girls during all postnatal exposure periods and BMI z-score; for each log increase in the estimated p,p'-DDE levels, BMI z-score increased by 0.23 (C.I. 95%: 0.01, 0.45) for the 0-6 months exposure period, 0.26 (C.I. 95%: 0.06, 0.47) for the 6-12 months exposure period, and 0.24 (C.I. 95%: 0.05, 0.43) for the 12-24 months exposure period. Conclusion: In this study of Japanese children, estimated postnatal p,p'-DDE levels were associated with increased BMI z-score at 42 months of age, mostly in girls. These results are in line with previous studies supporting that earlylife exposure to p,p'-DDE may be associated with higher BMI during childhood.

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Estimated postnatal p,p’-DDT and p,p’-DDE levels and body mass index at 42 months of age in a longitudinal study of Japanese children

et al. 2020

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“…2014), and organochlorine pesticides, including DDT, dichlorodiphenyldichloroethylene (DDE), hexachlorobenzene (HCB), aldrin, heptachlor, β-hexachlorocyclohexane (β-HCH), α-HCH, and heptachlor epoxide (Criswell et al. 2017; Du et al. 2016, 2017; Gladen et al.…”

Section: Resultsmentioning

confidence: 99%

Infant Dietary Exposures to Environmental Chemicals and Infant/Child Health: A Critical Assessment of the Literature

LaKind¹,

Lehmann

Davis

et al. 2018

Environ Health Perspect

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Background: The benefits of breastfeeding to the infant and mother have been well documented. It is also well known that breast milk contains environmental chemicals, and numerous epidemiological studies have explored relationships between background levels of chemicals in breast milk and health outcomes in infants and children. Objectives: In this paper, we examine epidemiological literature to address the following question: Are infant exposures to background levels of environmental chemicals in breast milk and formula associated with adverse health effects? We critically review this literature a ) to explore whether exposure–outcome associations are observed across studies, and b ) to assess the literature quality. Methods: We reviewed literature identified from electronic literature searches. We explored whether exposure–outcome associations are observed across studies by assessing the quality (using a modified version of a previously published quality assessment tool), consistency, and strengths and weaknesses in the literature. The epidemiological literature included cohorts from several countries and examined infants/children either once or multiple times over weeks to years. Health outcomes included four broad categories: growth and maturation, morbidity, biomarkers, and neurodevelopment. Results: The available literature does not provide conclusive evidence of consistent or clinically relevant health consequences to infants exposed to environmental chemicals in breast milk at background levels. Conclusions: It is clear that more research would better inform our understanding of the potential for health impacts from infant dietary exposures to environmental chemicals. A critical data gap is a lack of research on environmental chemicals in formula and infant/child health outcomes. https://doi.org/10.1289/EHP1954

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Monitoring of Organochlorine Pesticide Residues in Human Breast Milk in the Northern Governorates of Jordan in 2019/2020 Compared with the Results of 2015 Study

Antary

Alawi

Kiwan

et al. 2021

Bull Environ Contam Toxicol

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Longitudinal study of pesticide residue levels in human milk from Western Australia during 12 months of lactation: Exposure assessment for infants

Cited by 20 publications

References 66 publications

Estimated postnatal p,p’-DDT and p,p’-DDE levels and body mass index at 42 months of age in a longitudinal study of Japanese children

Estimated postnatal p,p’-DDT and p,p’-DDE levels and body mass index at 42 months of age in a longitudinal study of Japanese children

Infant Dietary Exposures to Environmental Chemicals and Infant/Child Health: A Critical Assessment of the Literature

Monitoring of Organochlorine Pesticide Residues in Human Breast Milk in the Northern Governorates of Jordan in 2019/2020 Compared with the Results of 2015 Study

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