Longitudinal study of muscle strength, quality, and adipose tissue infiltration

Delmonico, Matthew J.; Harris, Tamara B.; Visser, Marjolein; Park, Seok Won; Conroy, Molly B.; Velasquez-Mieyer, Pedro; Boudreau, Robert M.; Manini, Todd M.; Nevitt, M.; Newman, Anne B.; Goodpaster, Bret H.

doi:10.3945/ajcn.2009.28047

Cited by 1,093 publications

(731 citation statements)

References 29 publications

(26 reference statements)

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“…The loss of muscle strength, however, proceeds much faster than the loss of muscle mass (Goodpaster et al., 2006). This is in part attributed to neuromuscular coupling (Manini & Clark, 2012) and in part to intrinsic muscle characteristics such as intramuscular fat accumulation (Delmonico et al., 2009; Goodpaster et al., 2001; Marcus et al., 2012; Rivas et al., 2016) and mitochondrial function (Gouspillou, Bourdel‐Marchasson, et al. 2014; Hepple, 2016; Short et al., 2005).…”

Section: Introductionmentioning

confidence: 99%

Running‐wheel activity delays mitochondrial respiratory flux decline in aging mouse muscle via a post‐transcriptional mechanism

et al. 2017

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SummaryLoss of mitochondrial respiratory flux is a hallmark of skeletal muscle aging, contributing to a progressive decline of muscle strength. Endurance exercise alleviates the decrease in respiratory flux, both in humans and in rodents. Here, we dissect the underlying mechanism of mitochondrial flux decline by integrated analysis of the molecular network.Mice were given a lifelong ad libitum low‐fat or high‐fat sucrose diet and were further divided into sedentary and running‐wheel groups. At 6, 12, 18 and 24 months, muscle weight, triglyceride content and mitochondrial respiratory flux were analysed. Subsequently, transcriptome was measured by RNA‐Seq and proteome by targeted LC‐MS/MS analysis with 13C‐labelled standards. In the sedentary groups, mitochondrial respiratory flux declined with age. Voluntary running protected the mitochondrial respiratory flux until 18 months of age. Beyond this time point, all groups converged. Regulation Analysis of flux, proteome and transcriptome showed that the decline of flux was equally regulated at the proteomic and at the metabolic level, while regulation at the transcriptional level was marginal. Proteomic regulation was most prominent at the beginning and at the end of the pathway, namely at the pyruvate dehydrogenase complex and at the synthesis and transport of ATP. Further proteomic regulation was scattered across the entire pathway, revealing an effective multisite regulation. Finally, reactions regulated at the protein level were highly overlapping between the four experimental groups, suggesting a common, post‐transcriptional mechanism of muscle aging.

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Section: Introductionmentioning

confidence: 99%

Running‐wheel activity delays mitochondrial respiratory flux decline in aging mouse muscle via a post‐transcriptional mechanism

et al. 2017

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“…There are currently a number of studies that have examined the longitudinal changes in muscle mass and muscle function (e.g., Baltimore Longitudinal Study of Aging, the InCHIANTI study, Health ABC Study), but only a limited number examined study populations with a large age range (Metter et al 1997;Delmonico et al 2009;Hicks et al 2012). Most of them have found significant age-related declines in both muscle mass and muscle function.…”

Section: Introductionmentioning

confidence: 99%

“…) (Goodpaster et al 2006;Frontera et al 2008;Dey et al 2009;Marcell et al 2014;Reid et al 2014). It should also be noted that study populations often consisted of a homogenous group, mostly older adults, and although in most cases this is a strength, it allows for a limited interpretation of lifelong changes in these parameters (Goodpaster et al 2006;Frontera et al 2008;Delmonico et al 2009;Dey et al 2009;Reid et al 2014). Nevertheless, results between studies are similar, pointing out losses in muscle mass of up to 12.9 and 5.3 % after a 9.7-year followup period in men and women, respectively, aged 45-75 years (Hughes et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Age-related decline in muscle mass and muscle function in Flemish Caucasians: a 10-year follow-up

Charlier

Knaeps

Mertens

et al. 2016

AGE

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Aging is a complex process that is accompanied with changes in both muscle mass and muscle function (strength and performance). Therefore, the current longitudinal study aimed to provide a better insight in 10-year aging-related changes in whole-body muscle mass and strength performance of the leg extensors during the adult life span. Data were gathered within the framework of the first- (2002-2004: baseline) and third-generation Flemish Policy Research Center Sport (2012-2014: follow-up). Results are based on muscle characteristics data of 591 Flemish Caucasian adults (19-73 years, 381 men). Skeletal muscle mass (SMM) was determined with bioelectrical impedance analysis. Biodex Medical System 3® dynamometer was used to measure isometric (PT static120°) and isokinetic (PT dynamic60°a nd PT dynamic240°) strength, ballistic movement speed (S 20 % ), and muscular endurance (work) of the knee extensors. Overall strength performance was higher at both evaluation moments in men compared to women (p < 0.01). But only S 20 % declined significantly faster in men compared to women (p < 0.01). Age and baseline strength performance were negatively related with the change in strength performance, even when corrected for SMM, protein intake, and energy expenditure during sports (E sport ). In conclusion, strength performance was not associated with E sport in this study, but protein intake was associated with isometric strength in men, and with ballistic and isokinetic strength in women. Changes in S 20 % were significantly greater in men compared to women. Baseline values of strength performance and age were associated with changes in strength performance parameters, even after correction for SMM, protein intake, and E sport .

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“…1 As a consequence, most PAD patients present claudication symptoms, leading to impaired walking ability. 2,3 The aging process results in decreased muscle function, 4,5 which has been associated with an increased risk of falls, 6,7 leading to impairments in daily activities. 7,8 In PAD patients, aside from the effects of aging, lower-extremity strength deficits are associated with walking impairment, 9 reduced physical functioning, poor capacity for walking faster, and reduced stair-climbing ability.…”

Section: Introductionmentioning

confidence: 99%

Isokinetic Strength and Endurance in Proximal and Distal Muscles in Patients With Peripheral Artery Disease

Câmara

Ritti‐Dias

Menêses

et al. 2012

Annals of Vascular Surgery

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Longitudinal study of muscle strength, quality, and adipose tissue infiltration

Abstract: Loss of leg MT in older adults is greater than muscle CSA loss, which suggests a decrease in MQ. Additionally, aging is associated with an increase in IMF regardless of changes in weight or SF.

Cited by 1,093 publications

References 29 publications

Running‐wheel activity delays mitochondrial respiratory flux decline in aging mouse muscle via a post‐transcriptional mechanism

Running‐wheel activity delays mitochondrial respiratory flux decline in aging mouse muscle via a post‐transcriptional mechanism

Age-related decline in muscle mass and muscle function in Flemish Caucasians: a 10-year follow-up

Isokinetic Strength and Endurance in Proximal and Distal Muscles in Patients With Peripheral Artery Disease

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