Longitudinal Study of Depressive Symptoms and Progression of Insulin Resistance in Youth at Risk for Adult Obesity

Shomaker, Lauren B.; Tanofsky‐Kraff, Marian; Stern, Elizabeth; Miller, Rachel L.; Zocca, Jaclyn M.; Field, Sara E.; Yanovski, Susan Z.; Hubbard, Van S.; Yanovski, Jack A.

doi:10.2337/dc11-1131

Cited by 75 publications

(75 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The current study represents a secondary data analysis of baseline data collected from 107 adolescent girls taking part in a randomized controlled trial addressing depressive symptoms as a contributor to worsening insulin resistance and T2D risk (Shomaker et al, 2016; Shomaker, Tanofsky-Kraff, Stern, et al, 2011). Primary results from the trial have been published elsewhere (Shomaker et al, 2016; Shomaker, Kelly, et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Mindfulness and laboratory eating behavior in adolescent girls at risk for type 2 diabetes

et al. 2018

Self Cite

View full text Add to dashboard Cite

Mindfulness-based intervention has become increasingly popular to address disinhibited eating in obesity and type 2 diabetes (T2D). Theoretically, present-moment attention promotes the ability to recognize and respond to internal hunger cues and to differentiate physiological hunger from other stimuli. Yet, there is limited research describing the relationship of mindfulness with disinhibited eating patterns in adolescents. In this study, we evaluated the relationship of dispositional mindfulness to laboratory eating in 107 adolescent (12–17 years) girls at risk for T2D. Adolescents reported dispositional mindfulness, were evaluated for recent loss-of-control-eating (LOC-eating) by interview, and participated in two successive, standardized laboratory test meals to assess eating when hungry as well as eating in the absence of hunger (EAH). Adolescents rated state appetite throughout the test meal paradigms. In analyses adjusting for body composition and other possible confounds, mindfulness was inversely related to caloric intake during the EAH paradigm. Mindfulness did not relate to energy intake when hungry. Instead, there was a significant interaction of reported LOC-eating by state hunger, such that girls with recent, reported LOC-eating and high state hunger consumed more calories when hungry, regardless of mindfulness. Findings suggest that in girls at risk for T2D, mindfulness may play a role in disinhibited eating. A propensity for LOC-eating may be most salient for overeating in a high hunger state.

show abstract

Section: Methodsmentioning

confidence: 99%

“…The Center for Epidemiologic Studies-Depression Scales (Radloff, 1977) was used to determine inclusion eligibility (score ≥16) for the parent study, a randomized controlled trial examining depressive symptoms as a contributor to worsening insulin resistance and T2D risk (Shomaker et al, 2016; Shomaker, Tanofsky-Kraff, Stern, et al, 2011). …”

Section: Methodsmentioning

confidence: 99%

Mindfulness and laboratory eating behavior in adolescent girls at risk for type 2 diabetes

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…This pathology raises the risk of developing depression [2], the third most frequent mental disorder in Europe [3]. Reciprocally, depression has been proposed as a risk factor for the development of obesity [4]. More globally, recent meta-analyses have confirmed the two-way relationship between the two pathologies [5,6,2].…”

Section: Introductionmentioning

confidence: 93%

Hippocampal GSK3β as a Molecular Link Between Obesity and Depression

et al. 2014

View full text Add to dashboard Cite

Obesity is considered as a risk factor for mood disorders including depression. Nevertheless, the mechanisms underlying this association are not clearly understood. To address this issue, we investigated the impact of high-fat (HF)-diet-induced obesity on depressive-like behavior and on serotonin (5-HT)-dependent Akt/glycogen synthase kinase 3β (GSK3β) signaling in the dentate gyrus (DG) of the hippocampus, which has been associated with mood regulation. We first showed that a HF diet induced significant overweight and hyperglycemia as well as a depressive-like behavior in adult Wistar rats. By using an ex vivo approach on brain slices, we demonstrated that 5-HT activates the Akt/GSK3β cascade in the DG of control chow (C) diet-fed animals and that a 16-week HF diet feeding abolishes this activation, concurrently with a desensitization of leptin and insulin signaling in the same region. Furthermore, depressive-like behavior inversely correlated with 5-HT-induced phosphorylation of GSK3β in the subgranular neurons of the DG. Interestingly, a substitution of HF with C diet for 6 weeks induced a total loss of depressive symptoms, whereas body weight and glycemia remained significantly higher compared to control rats. In addition, food restoration led to a recovery of the Akt/GSK3β signaling pathway activation in the DG. In parallel, we observed a negative correlation between body weight and cell proliferation in the subgranular zone of the DG. To conclude, we provide evidence for a desensitization of 5-HT-induced Akt/GSK3β signaling and an impaired cell proliferation in the DG by HF diet, suggesting novel molecular mechanisms linking obesity to depression.

show abstract

“…Chronic stress may mediate the relationship between military life and metabolic risk (37). Depressive symptoms have also been linked to (38), and predictive of (39), insulin resistance in youth. Indeed, the daughters of service-members reported greater depression; in fact, military-dependents’ depression scores placed them in the mild depression range, whereas civilian adolescents’ scores indicated only minimal depression (25).…”

Section: Discussionmentioning

confidence: 99%

Comparison of overweight and obese military‐dependent and civilian adolescent girls with loss‐of‐control eating

Schvey

Sbrocco

Stephens

et al. 2015

Intl J Eating Disorders

Self Cite

View full text Add to dashboard Cite

Objective Limited data suggest that the children of U.S. service members may be at increased risk for disordered-eating. To date, no study has directly compared adolescent military-dependents to their civilian peers along measures of eating pathology and associated correlates. We, therefore, compared overweight and obese adolescent female military-dependents to their civilian counterparts along measures of eating-related pathology and psychosocial functioning. Method Adolescent females with a BMI between the 85th and 97th percentiles and who reported loss-of-control eating completed interview and questionnaire assessments of eating-related and general psychopathology. Results 23 military-dependents and 105 civilians participated. Controlling for age, race, and BMI-z, military-dependents reported significantly more binge episodes per month (p<.01), as well as greater eating-concern, shape-concern, and weight-concern (p’s<.01) than civilians. Military-dependents also reported more severe depression (p<.05). Discussion Adolescent female military-dependents may be particularly vulnerable to disordered-eating compared to civilian peers. This potential vulnerability should be considered when assessing military-dependents.

show abstract

Longitudinal Study of Depressive Symptoms and Progression of Insulin Resistance in Youth at Risk for Adult Obesity

Cited by 75 publications

References 25 publications

Mindfulness and laboratory eating behavior in adolescent girls at risk for type 2 diabetes

Mindfulness and laboratory eating behavior in adolescent girls at risk for type 2 diabetes

Hippocampal GSK3β as a Molecular Link Between Obesity and Depression

Comparison of overweight and obese military‐dependent and civilian adolescent girls with loss‐of‐control eating

Contact Info

Product

Resources

About