Longitudinal studies of ischemic penumbra by using 18 F-FDG PET and MRI techniques in permanent and transient focal cerebral ischemia in rats

Sobrado, Mónica; Delgado, Montserrat González; Fernández-Valle, E.; Garcı́a-Garcı́a, Luis; Torres, Magdalena; Sánchez‐Prieto, José; Vivancos, José; Manzanares, Rafael; Moro, Marı́a A.; Pozo, Miguel A.; Lizasoaín, Ignacio

doi:10.1016/j.neuroimage.2011.04.045

Cited by 46 publications

(38 citation statements)

References 40 publications

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“…The pMCAO was achieved by ligature as described previously (31). In sham-operated control rats, the middle cerebral artery was exposed but not occluded.…”

Section: Methodsmentioning

confidence: 99%

Amelioration of ischemic brain damage by peritoneal dialysis

Godino¹,

Romera²,

Sánchez-Tomero³

et al. 2013

J. Clin. Invest.

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Ischemic stroke is a devastating condition, for which there is still no effective therapy. Acute ischemic stroke is associated with high concentrations of glutamate in the blood and interstitial brain fluid. The inability of the tissue to retain glutamate within the cells of the brain ultimately provokes neuronal death. Increased concentrations of interstitial glutamate exert further excitotoxic effects on healthy tissue surrounding the infarct zone. We developed a strategy based on peritoneal dialysis to reduce blood glutamate levels, thereby accelerating brain-to-blood glutamate clearance. In a rat model of stroke, this simple procedure reduced the transient increase in glutamate, consequently decreasing the size of the infarct area. Functional magnetic resonance imaging demonstrated that the rescued brain tissue remained functional. Moreover, in patients with kidney failure, peritoneal dialysis significantly decreased glutamate concentrations. Our results suggest that peritoneal dialysis may represent a simple and effective intervention for human stroke patients.

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“…The pMCAO was achieved by ligature as described previously (31). In sham-operated control rats, the middle cerebral artery was exposed but not occluded.…”

Section: Methodsmentioning

confidence: 99%

Amelioration of ischemic brain damage by peritoneal dialysis

Godino¹,

Romera²,

Sánchez-Tomero³

et al. 2013

J. Clin. Invest.

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“…Additionally, although histopathological evidence for reperfusion injury in myocardial ischemia-reperfusion (IR) has been described in animal models, there has been less attention focused on direct changes in heart mitochondria, despite their central role in cell metabolism. Some studies had reported that transient ischemia induced less damage than permanent ischemia (Preda and Burlacu, 2010;Sobrado et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Quantitative and qualitative analysis of heart mitochondria for evaluating the degree of myocardial injury utilizing atomic force microscopy

Lee

Jeong

Lee

et al. 2013

Micron

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“…Others have reported some return of oxygen consumption or glucose uptake or a continued depressed usage. 16,17,29 However, local cerebral oxygen extraction remained elevated and venous O 2 saturations remain low in the ischemic-reperfused region. Tissue oxygen tension may or may not return to normal during reperfusion.…”

mentioning

confidence: 99%

Cerebral Ischemia and Reperfusion Increases the Heterogeneity of Local Oxygen Supply/Consumption Balance

Weiss

Grayson

Liu

et al. 2013

Stroke

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Background and Purpose-After cerebral vessel blockage, local blood flow and O 2 consumption becomes lower and oxygen extraction increases. With reperfusion, blood flow is partially restored. We examined the effects of ischemia-reperfusion on the heterogeneity of local venous oxygen saturation in rats in order to determine the pattern of microregional O 2 supply/consumption balance in reperfusion. Methods-The middle cerebral artery was blocked for 1 hour using the internal carotid approach in 1 group (n=9) and was then reperfused for 2 hours in another group (n=9) of isoflurane-anesthetized rats. Regional cerebral blood flow was determined using a C 14 -iodoantipyrine autoradiographic technique. Regional small vessel arterial and venous oxygen saturations were determined microspectrophotometrically. Results-After 1 hour of ischemia, local cerebral blood flow (92±10 versus 50±10 mL/min per 100 g) and O 2 consumption (4.5±0.6 versus 2.7±0.5 mL O 2 /min per 100 g) decreased compared with the contralateral cortex. Oxygen extraction increased (4.7±0.2 versus 5.4±0.3 mL O 2 /100 mL) and the variation in small vein (20-60 μm) O 2 saturation as determined by its coefficient of variation (=100×SD/mean) increased (5.5 versus 10.5). With 2 hours of reperfusion, the blood flow decrement was reduced and O 2 consumption returned to the value in the contralateral cortex. Oxygen extraction remained elevated in the ischemic-reperfused area and the coefficient of variation of small vein O 2 saturation increased further (17.3). Conclusions-These

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Longitudinal studies of ischemic penumbra by using 18 F-FDG PET and MRI techniques in permanent and transient focal cerebral ischemia in rats

Cited by 46 publications

References 40 publications

Amelioration of ischemic brain damage by peritoneal dialysis

Amelioration of ischemic brain damage by peritoneal dialysis

Quantitative and qualitative analysis of heart mitochondria for evaluating the degree of myocardial injury utilizing atomic force microscopy

Cerebral Ischemia and Reperfusion Increases the Heterogeneity of Local Oxygen Supply/Consumption Balance

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