Longitudinal strain and myocardial work in symptomatic patients having recovered from COVID-19 and possible associations with the severity of the disease

D’Ávila, Luciana Bartolomei Orru; Milani, Mauricio; Le Bihan, David C. S.; de Lima, Alexandra Correa Gervazoni Balbuena; Milani, Juliana Goulart Prata Oliveira; Cipriano, Graziella França Bernardelli; da Silva, Vinicius Zacarias Maldaner; Cipriano Jr, Gerson

doi:10.1007/s10554-023-03042-2

Int J Cardiovasc Imaging

2024

DOI: 10.1007/s10554-023-03042-2

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Longitudinal strain and myocardial work in symptomatic patients having recovered from COVID-19 and possible associations with the severity of the disease

Luciana Bartolomei Orru D’Ávila,

Mauricio Milani,

David C. S. Le Bihan

et al.

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2024

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Myocardial Work Indices in Patients Recently Recovered from Mild-to-Moderate COVID-19

Dankowski,

Sacharczuk,

Fedorowicz

et al. 2024

JCM

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Background/Objectives: Persistent cardiovascular issues are common in COVID-19 survivors, making the detection of subtle myocardial injuries critical. This study evaluates myocardial work (MW) indices in patients recently recovering from mild-to-moderate COVID-19. Methods: A total of 105 recently recovered COVID-19 patients (who had a mean age of 52 years) underwent comprehensive laboratory testing and advanced echocardiographic assessments. The median time since their COVID-19 infections was 56 days (IQR: 42–71). The cohort was stratified based on high-sensitive troponin I (hs-TnI) levels: undetectable versus detectable. The echocardiographic analysis utilized pressure-strain loops to evaluate MW indices. Results: Detectable hs-TnI levels were observed in 42% of patients. The median values of MW indices for the entire group were slightly below normal values: global work index (GWI)—1834 mmHg% (IQR 1168–2054 mmHg%), global constructive work (GCW)—2130 mmHg% (IQR 2010–2398 mmHg%), global wasted work (GWW)—119 mmHg% (IQR 78–175 mmHg%), and global work efficiency (GWE)—94% (IQR 92–96%). Patients with detectable hs-TnI had higher GWW (168 vs. 97 mmHg%, p < 0.005) and lower GWE (93% vs. 95%, p < 0.005). In multiple regression analysis, strain dispersion (PSD) was the sole predictor for GWW (β = 0.67, p < 0.001), while for GWE, PSD (β = −0.67, p < 0.001) and LVEF (β = 0.16, p = 0.05) were significant predictors. Conclusions: Among patients recently recovering from mild-to-moderate COVID-19, elevated hs-TnI levels are linked with a reduction in GWE and an increase in GWW. PSD is an important predictor of myocardial inefficiency and wasted work. In this group, disruptions in the timing and coordination of cardiac muscle contractions may play a key pathophysiological role in reducing the efficiency of the heart’s performance.

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Myocardial Work Indices in Patients Recently Recovered from Mild-to-Moderate COVID-19

Dankowski,

Sacharczuk,

Fedorowicz

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

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Longitudinal strain and myocardial work in symptomatic patients having recovered from COVID-19 and possible associations with the severity of the disease

Cited by 1 publication

References 51 publications

Myocardial Work Indices in Patients Recently Recovered from Mild-to-Moderate COVID-19

Myocardial Work Indices in Patients Recently Recovered from Mild-to-Moderate COVID-19

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