Longitudinal sex differences of externalising and internalising depression symptom trajectories: Implications for assessment of depression in men from an online study

Rice, Simon; Fallon, Barry John; Aucote, Helen M.; Möller-Leimkühler, A.M.; Treeby, Matt S; Amminger, G. Paul

doi:10.1177/0020764014540149

Cited by 63 publications

(41 citation statements)

References 13 publications

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“…DSM-IV andDSM 5 (American Psychiatric Association, 2000, 2013) were used to identify standard criteria for depression. Alternative criteria were identified on the basis of previous evidence in the research literature (Martin et al, 2013;Rice et al, 2015). See Table 1 for a list of alternative criteria included in the study.…”

Section: Sample and Instrumentmentioning

confidence: 99%

Symptom endorsement in men versus women with a diagnosis of depression: A differential item functioning approach

Cavanagh

Wilson

Caputi

et al. 2016

Int J Soc Psychiatry

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. (2016). Symptom endorsement in men versus women with a diagnosis of depression: A differential item functioning approach. International Journal of Social Psychiatry, 62 (6), 549-559.Symptom endorsement in men versus women with a diagnosis of depression: A differential item functioning approach Abstract Background: There is some evidence that, in contrast to depressed women, depressed men tend to report alternative symptoms that are not listed as standard diagnostic criteria. This may possibly lead to an under-or misdiagnosis of depression in men. Aims: This study aims to clarify whether depressed men and women report different symptoms. Methods: This study used data from the 2007 Australian National Survey of Mental Health and Wellbeing that was collected using the World Health Organization's Composite International Diagnostic Interview. Participants with a diagnosis of a depressive disorder with 12-month symptoms (n = 663) were identified and included in this study. Differential item functioning (DIF) was used to test whether depressed men and women endorse different features associated with their condition. Results: Gender-related DIF was present for three symptoms associated with depression. Depressed women were more likely to report 'appetite/weight disturbance', whereas depressed men were more likely to report 'alcohol misuse' and 'substance misuse'. Conclusion: While the results may reflect a greater risk of cooccurring alcohol and substance misuse in men, inclusion of these features in assessments may improve the detection of depression in men, especially if standard depressive symptoms are under-reported.

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Section: Sample and Instrumentmentioning

confidence: 99%

Symptom endorsement in men versus women with a diagnosis of depression: A differential item functioning approach

Cavanagh

Wilson

Caputi

et al. 2016

Int J Soc Psychiatry

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“…Additionally, some have suggested that sex differences in the epidemiology of depression may be partly related to the absence of “male-typical,” externalizing symptoms from standard diagnostic criteria (Martin, Neighbors, & Griffith, 2013; Rice et al, in press ). …”

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confidence: 99%

Interoceptive dysfunction: Toward an integrated framework for understanding somatic and affective disturbance in depression.

Harshaw

2015

Psychological Bulletin

213

147

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Depression is characterized by disturbed sleep and eating, a variety of other, nonspecific somatic symptoms, and significant somatic comorbidities. Why there is such close association between cognitive and somatic dysfunction in depression is nonetheless poorly understood. An explosion of research in the area of interoception—the perception and interpretation of bodily signals—over the last decade nonetheless holds promise for illuminating what have until now been obscure links between the social, cognitive-affective, and somatic features of depression. This paper reviews rapidly accumulating evidence that both somatic signaling and interoception are frequently altered in depression. This includes comparative studies showing vagus-mediated effects on depression-like behaviors in rodent models as well as studies in humans indicating both dysfunction in the neural substrates for interoception (e.g., vagus, insula, anterior cingulate cortex) and reduced sensitivity to bodily stimuli in depression. An integrative framework for organizing and interpreting this evidence is put forward which incorporates (a) multiple potential pathways to interoceptive dysfunction; (b) interaction with individual, gender, and cultural differences in interoception; and (c) a developmental psychobiological systems perspective, emphasizing likely differential susceptibility to somatic and interoceptive dysfunction across the lifespan. Combined with current theory and evidence, it is suggested that core symptoms of depression (e.g., anhedonia, social deficits) may be products of disturbed interoceptive-exteroceptive integration. More research is nonetheless needed to fully elucidate the relationship between mind, body, and social context in depression.

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“…However, it has been challenging to disentangle the various biological, psychological, and cultural contributors to these sex/gender gaps in humans (Mogil, 2012), despite recent findings implicating different cellular mechanisms of pain sensitivity in male and female mice of certain strains (Sorge et al, 2015). Neuroimaging and electroencephalography have yet to reveal a clear neural basis for sex/ gender difference in human pain processing, nor do other physiological or hormonal measures demonstrate an obvious mechanism for differences in pain threshold and tolerance (Racine et al, 2012b;Bartley and Fillingim, 2013).…”

Section: Gender Dimensions Of Male-female Differences In the Human Brmentioning

confidence: 99%

“…Among adults, gender differences in pain thresholds and tolerance are often reduced or eliminated in studies that control for individual differences in anxiety, gender role endorsement, selfefficacy, and coping style (Jackson et al, 2002;Fillingim et al, 2009;Mogil, 2012). Other social variables, including cultural origin and the gender of the experimenter, also modify sex/gender differences in pain perception (Racine et al, 2012b). When it comes to clinical practice, even a leading researcher on animal sex difference concedes that analgesic treatments must always be titrated on an individual basis, where biological sex is but one of many sources of interindividual variability (Mogil, 2012).…”

Section: Gender Dimensions Of Male-female Differences In the Human Brmentioning

confidence: 99%

Sex in Context: Limitations of Animal Studies for Addressing Human Sex/Gender Neurobehavioral Health Disparities

Eliot

Richardson

2016

J. Neurosci.

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Many brain and behavioral disorders differentially affect men and women.The new National Institutes of Health requirement to include both male and female animals in preclinical studies aims to address such health disparities, but we argue that the mandate is not the best solution to this problem. Sex differences are highly species-specific, tied to the mating system and social ecology of a given species or even strain of animal. In many cases, animals poorly replicate male-female differences in brain-related human diseases. Sex/gender disparities in human health have a strong sociocultural component that is intimately entangled with biological sex and challenging to model in animals. We support research that investigates sex-related variables in hypothesis-driven studies of animal brains and behavior. However, institutional policies that require sex analysis and give it special salience over other sources of biological variance can distort research. We caution that the costly imposition of sex analysis on nearly all animal research entrenches the presumption that human brain and behavioral differences are largely biological in origin and overlooks the potentially more powerful social, psychological, and cultural contributors to male-female neurobehavioral health gaps.

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Longitudinal sex differences of externalising and internalising depression symptom trajectories: Implications for assessment of depression in men from an online study

Cited by 63 publications

References 13 publications

Symptom endorsement in men versus women with a diagnosis of depression: A differential item functioning approach

Symptom endorsement in men versus women with a diagnosis of depression: A differential item functioning approach

Interoceptive dysfunction: Toward an integrated framework for understanding somatic and affective disturbance in depression.

Sex in Context: Limitations of Animal Studies for Addressing Human Sex/Gender Neurobehavioral Health Disparities

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