Longitudinal Serum Testosterone, Luteinizing Hormone, and Follicle-Stimulating Hormone Levels in a Population-Based Sample of Long-Term Testicular Cancer Survivors

Sprauten, Mette; Brydøy, Marianne; Haugnes, Hege Sagstuen; Cvancarova, Milada; Bjøro, Trine; Bjerner, Johan; Fosså, Sophie D.; Oldenburg, Jan

doi:10.1200/jco.2013.51.2715

Cited by 84 publications

(71 citation statements)

References 45 publications

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“…74 Endocrine (inadequate testosterone production with compensatory increase of luteinizing hormone [LH] level) and exocrine hypogonadism (decreased spermatogenesis with increase of follicle-stimulating hormone [FSH] level) are two of the main long-term adverse effects that TCS may develop.…”

Section: Hypogonadism Pathogenesismentioning

confidence: 99%

Long-term Morbidity of Testicular Cancer Treatment

Fung

Fosså

Williams

et al. 2015

Urologic Clinics of North America

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Section: Hypogonadism Pathogenesismentioning

confidence: 99%

Long-term Morbidity of Testicular Cancer Treatment

Fung

Fosså

Williams

et al. 2015

Urologic Clinics of North America

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“…Several risk factors of post-treatment hypogonadism have been identified, 20,26,27 these including treatment intensity, pre-treatment hypogonadism, age, testicular microlithiasis.…”

Section: Impact Of Cancer Treatment and Other Risk Factorsmentioning

confidence: 99%

Hypogonadism in young men treated for cancer

Giwercman¹,

Giwercman²

2015

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An ever-increasing proportion of young males treated for cancer are cured. Therefore, one of the major challenges of modern Clinical Oncology is to ensure good quality of life. Cancer disease per se as well as cancer treatment may have a negative impact on androgen production, thereby leading to subclinical or clinically overt hypogonadism. Since the symptoms of androgen deficiency are rather unspecific, it is important that reproductive hormone levels be checked in young men who have been treated for cancer. As androgen deficiency in men is associated with increased long-term risk of osteoporosis as well as cardiovascular and metabolic disease, those cancer survivors who present with signs of insufficient androgen production should be followed and preventive as well as therapeutic measures, including androgen replacement therapy, should be applied according to the current guidelines.

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“…To maximize benefit, these options should be pursued prior to gonadotoxic therapy. Additionally, while age-related decline of gonadal function is less clearly defined in males compared to females, there are some studies suggesting a decline in testosterone and sperm production over time in healthy males, as well as progression of oligospermia to azoospermia in males exposed to gonadotoxic agents (16)(17)(18). The "optimal" age for fertility preservation has been identified for certain populations, discussed further in the next section.…”

Section: Fertility Preservation Options For Malesmentioning

confidence: 99%

Fertility counseling and preservation: considerations for the pediatric endocrinologist

Saraf

Nahata

2017

Transl. Pediatr

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Infertility is a distressing consequence of numerous pediatric medical conditions and treatments.The field of pediatric fertility preservation has expanded rapidly over the past decade, and clinical guidelines emphasize the importance of discussing infertility risk and fertility preservation options with patients and families in a timely manner. Understanding the various mechanisms and presentations of fertility issues across diagnoses is imperative to provide counseling to patients and families, and identify individuals who may benefit from fertility preservation. The goals of this manuscript are to outline current fertility preservation options in pediatrics, review populations at-risk for infertility that are seen in pediatric endocrinology, and discuss other important issues related to fertility preservation including ethical considerations.

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Longitudinal Serum Testosterone, Luteinizing Hormone, and Follicle-Stimulating Hormone Levels in a Population-Based Sample of Long-Term Testicular Cancer Survivors

Abstract: Long-term TCSs are at risk of premature hormonal aging. Our findings may pertain to cancer survivors in general, underlining the importance of extended follow-up.

Cited by 84 publications

References 45 publications

Long-term Morbidity of Testicular Cancer Treatment

Long-term Morbidity of Testicular Cancer Treatment

Hypogonadism in young men treated for cancer

Fertility counseling and preservation: considerations for the pediatric endocrinologist

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