Longitudinal serum neurofilament light kinetics in post‐anoxic encephalopathy
Giulio Disanto,
Michele Villa,
Aleksandra Maleska Maceski
et al.
Abstract:Serum neurofilament light (sNfL) is a promising marker of outcome after cardiac arrest, but its kinetics are unclear. We prospectively measured sNfL concentrations in 62 patients at 0, 1, 3, 5, 7 and 10 days after cardiac arrest. Survivors and non‐survivors had similar sNfL at admission (14.2 [8.6–21.9] vs. 22.5 [14.2–46.9] pg/mL) but largely different at 24 h (16.4 [10.2–293] vs. 464.3 [151.8–1658.2], respectively). The AUC for sNfL concentrations predicting death was above 0.95 from Day 1 to 10 (highest on D… Show more
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