Longitudinal Relationship of Depressive and Anxiety Symptoms With Dyslipidemia and Abdominal Obesity

Dortland, Arianne K. B. van Reedt; Giltay, Erik J.; Veen, Tineke van; Zitman, Frans G.; Penninx, Brenda W. J. H.

doi:10.1097/psy.0b013e318274d30f

Cited by 85 publications

(75 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies indicate that presence of depression or anxiety or more severe baseline levels of psychopathology are associated with poor metabolic outcomes over time, particularly obesity and dyslipidemia,6, 14 and sometimes over extended periods, up to 15 years later 59. Other studies indicate effects in the opposite direction 13, 60.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, most of the current evidence involves depressive symptoms, whereas associations for anxiety symptoms or diagnosis of depression and anxiety have been infrequently reported, and results have been inconsistent 13, 14, 15. Consequently, it remains unclear as to whether, over time, psychopathology impairs components of the metabolic syndrome, or vice versa.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bidirectional Prospective Associations of Metabolic Syndrome Components With Depression, Anxiety, and Antidepressant Use

et al. 2016

View full text Add to dashboard Cite

BackgroundMetabolic syndrome components—waist circumference, high‐density lipoprotein cholesterol (HDL‐C), triglycerides, systolic blood pressure and fasting glucose—are cross‐sectionally associated with depression and anxiety with differing strength. Few studies examine the relationships over time or whether antidepressants have independent effects.MethodsParticipants were from the Netherlands Study of Depression and Anxiety (NESDA; N = 2,776; 18–65 years; 66% female). At baseline, 2‐ and 6‐year follow‐up, participants completed diagnostic interviews, depression and anxiety symptom inventories, antidepressant use assessment, and measurements of the five metabolic syndrome components. Data were analyzed for the consistency of associations between psychopathology indicators and metabolic syndrome components across the three assessment waves, and whether psychopathology or antidepressant use at one assessment predicts metabolic dysregulation at the next and vice versa.ResultsConsistently across waves, psychopathology was associated with generally poorer values of metabolic syndrome components, particularly waist circumference and triglycerides. Stronger associations were observed for psychopathology symptom severity than diagnosis. Antidepressant use was independently associated with higher waist circumference, triglycerides and number of metabolic syndrome abnormalities, and lower HDL‐C. Symptom severity and antidepressant use were associated with subsequently increased number of abnormalities, waist circumference, and glucose after 2 but not 4 years. Conversely, there was little evidence that metabolic syndrome components were associated with subsequent psychopathology outcomes.ConclusionsSymptom severity and antidepressant use were independently associated with metabolic dysregulation consistently over time and also had negative consequences for short‐term metabolic health. This is of concern given the chronicity of depression and anxiety and prevalence of antidepressant treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bidirectional Prospective Associations of Metabolic Syndrome Components With Depression, Anxiety, and Antidepressant Use

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Three studies have reported on the prospective relationship between anxiety and later weight gain, with two finding associations between baseline anxiety and increased weight at 2-year follow-up. In one of these studies, this relationship was not moderated by sex and was no longer significant for either men or women after controlling for depression [22]. In the other study, the pattern of results by sex changed after adjusting for baseline depression and physical activity.…”

Section: Long-term Studies (>5 Years)mentioning

confidence: 93%

Sex Differences in Obesity and Mental Health

Tronieri

Wurst

Pearl

et al. 2017

Curr Psychiatry Rep

View full text Add to dashboard Cite

Research on sex differences in the relationship between obesity and psychiatric disorders is more abundant in some areas, such as depression and eating disorders, than others, such as anxiety, trauma, and substance use. However, for most of the disorders, their relationships with obesity and sex are complex and are usually moderated by additional variables. Thus, studies that find stronger relationships for women between depression and obesity cross-sectionally do not tell the whole story, as longitudinal studies suggest that this relationship may also be present among men, particularly when confounders are considered. For those with eating disorders, men and women with obesity are fairly equally affected, and weight and shape concerns may play a role in maintaining these behaviors for both sexes. Weight stigma, though, seems to have worse consequences for women than men with obesity. Sex differences exist in relation to the associations between mental health and obesity. However, these differences vary by disorder, with disorder-specific moderators playing a role, such as age for depressive disorders, comorbid depression for anxiety disorders, and weight and shape concerns for eating disorders. More work is needed to understand if sex differences play a role in the relationship between obesity and anxiety, trauma, and substance use disorders.

show abstract

“…More specifically, a bidirectional association was found between depression and obesity with obesity increasing the risk of depression and prior depression increasing the likelihood of obesity. Several studies have found that abdominal obesity in particular may be characteristic of depression (Carpiniello et al, 2012, Rivenes et al, 2009, van Reedt Dortland et al, 2013.…”

Section: Is There An Association Between Obesity and Psychiatry Disormentioning

confidence: 99%

Obesity and psychiatric disorders: Commonalities in dysregulated biological pathways and their implications for treatment

Lopresti

Drummond

2013

Progress in Neuro-Psychopharmacology and Biological Psychiatry

193

128

View full text Add to dashboard Cite

Rates of obesity are higher than normal across a range of psychiatric disorders, including major depressive disorder, bipolar disorder, schizophrenia and anxiety disorders. While the problem of obesity is generally acknowledged in mental health research and treatment, an understanding of their bi-directional relationship is still developing. In this review the association between obesity and psychiatric disorders is summarised, with a specific emphasis on similarities in their disturbed biological pathways; namely neurotransmitter imbalances, hypothalamus-pituitary-adrenal axis disturbances, dysregulated inflammatory pathways, increased oxidative and nitrosative stress, mitochondrial disturbances, and neuroprogression. The applicability and effectiveness of weight-loss interventions in psychiatric populations is reviewed along with their potential efficacy in ameliorating disturbed biological pathways, particularly those mediating inflammation and oxidative stress. It is proposed that weight loss may not only be an effective intervention to enhance physical health but may also improve mental health outcomes and slow the rate of neuroprogressive disturbances in psychiatric disorders. Areas of future research to help expand our understanding of the relationship between obesity and psychiatric disorders are also outlined.

show abstract

Longitudinal Relationship of Depressive and Anxiety Symptoms With Dyslipidemia and Abdominal Obesity

Cited by 85 publications

References 61 publications

Bidirectional Prospective Associations of Metabolic Syndrome Components With Depression, Anxiety, and Antidepressant Use

Bidirectional Prospective Associations of Metabolic Syndrome Components With Depression, Anxiety, and Antidepressant Use

Sex Differences in Obesity and Mental Health

Obesity and psychiatric disorders: Commonalities in dysregulated biological pathways and their implications for treatment

Contact Info

Product

Resources

About