Longitudinal relationship between physical activity and lung health in patients with cystic fibrosis

Schneiderman, Jane E.; Wilkes, Donna L.; Atenafu, Eshetu G.; Nguyen, Thanh Hung; Wells, Greg D.; Alarie, Nancy; Tullis, Elizabeth; Lands, Larry C.; Coates, Allan L.; Corey, Mary; Ratjen, Félix

doi:10.1183/09031936.00055513

Cited by 126 publications

(139 citation statements)

References 36 publications

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“…Cox et al [4] reported higher scores in QoL by adult subjects with CF who performed ≥ 30 minutes of moderate-vigorous PA daily compared to those who performed <30 minutes daily. In a cross-sectional study on children with CF, PA was found to correlate quite strongly with QOL [7]. In our study we found a 9-points higher body image perception in the more active group, even if no statistical significance were detected in difference of QOL scores between groups previous studies reported similar results [29].…”

Section: Discussionsupporting

confidence: 78%

“…Others described no significant differences in PA to healthy peers [2,7,10]. Regarding pulmonary function, some authors reported that higher PA levels were associated with a slower rate of decline in FEV 1 , specifically in girls with CF [5,11].…”

Section: Introductionmentioning

confidence: 99%

“…A progressive decline in PA levels and exercise participation occurs during adolescence both in healthy subjects and youth with CF [7].…”

Section: Introductionmentioning

confidence: 99%

“…A growing body of research has demonstrated that exercise training and physical activity (PA) are associated with decreased mortality [3], slower rate of decline in respiratory function [4,5], higher bone mineral density [6], improved nutritional status and health-related quality of life [7].…”

Section: Introductionmentioning

confidence: 99%

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Physical Activity Levels and Performance in Italian Adolescents with Cystic Fibrosis: A Multicenter Cross-sectional Study

Cazzarolli¹,

Tridello²,

Tartali³

et al. 2017

J Pulm Respir Med

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

“…A progressive decline in PA levels and exercise participation occurs during adolescence both in healthy subjects and youth with CF [7].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Physical Activity Levels and Performance in Italian Adolescents with Cystic Fibrosis: A Multicenter Cross-sectional Study

Cazzarolli¹,

Tridello²,

Tartali³

et al. 2017

J Pulm Respir Med

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“…Exercise in CF is increasingly recognised to be important to the maintenance of good lung function and bone health, and to the patient's sense of wellbeing [66,67]. The following three presentations at the ERS congress discussed physical activity levels and the potential benefits induced by an active lifestyle.…”

Section: Exercise and Physiotherapymentioning

confidence: 99%

Paediatrics in Barcelona

et al. 2014

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Physical exercise training for cystic fibrosis

Radtke

Nolan

Hebestreit

et al. 2015

Cochrane Database of Systematic Reviews

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BACKGROUND: Physical exercise training may form an important part of regular care for people with cystic fibrosis. This is an update of a previously published review. OBJECTIVES: To assess the effects of physical exercise training on exercise capacity by peak oxygen consumption, pulmonary function by forced expiratory volume in one second, health-related quality of life and further important patient-relevant outcomes in people with cystic fibrosis. SEARCH METHODS: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register which comprises references identified from comprehensive electronic database searches and handsearches of relevant journals and abstract books of conference proceedings.Date of the most recent search: 04 May 2017.We searched ongoing trials registers (clinicaltrials.gov and the WHO ICTRP). Date of most recent search: 10 August 2017. SELECTION CRITERIA: All randomised and quasi-randomised controlled clinical trials comparing exercise training of any type and a minimum duration of two weeks with conventional care (no training) in people with cystic fibrosis. DATA COLLECTION AND ANALYSIS: Two authors independently selected studies for inclusion, assessed methodological quality and extracted data. The quality of the evidence was assessed using the GRADE system. MAIN RESULTS: Of the 83 studies identified, 15 studies which included 487 participants, met the inclusion criteria. The numbers in each study ranged from nine up to 72 participants; two studies were in adults, seven were in children and adolescents and six studies included all age ranges. Four studies of hospitalised participants lasted less than one month and 11 studies were outpatient-based, lasting between two months and three years. The studies included participants with a wide range of disease severity and employed differing levels of supervision with a mixture of types of training. There was also wide variation in the quality of the included studies.This systematic review shows very low-to low-quality evidence from both short-and long-term studies that in people with cystic fibrosis aerobic or anaerobic physical exercise training (or a combination of both) has a positive effect on aerobic exercise capacity, pulmonary function and health-related quality of life. No study reported on mortality; two studies reported on adverse events (moderate-quality evidence); one of each study reported on pulmonary exacerbations (low-quality evidence) and diabetic control (very low-quality evidence). Although improvements were not consistent between studies and ranged from no effects to clearly positive effects, the most consistent effects of the heterogeneous exercise training modalities and durations were found for maximal aerobic exercise capacity (in four out of seven studies) with unclear effects on forced expiratory volume in one second (in two out of 11 studies) and health-related quality of life (in two out of seven studies). AUTHORS' CONCLUSIONS: Evidence about the efficacy of physical exercise training in cystic fibros...

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Longitudinal relationship between physical activity and lung health in patients with cystic fibrosis

Cited by 126 publications

References 36 publications

Physical Activity Levels and Performance in Italian Adolescents with Cystic Fibrosis: A Multicenter Cross-sectional Study

Physical Activity Levels and Performance in Italian Adolescents with Cystic Fibrosis: A Multicenter Cross-sectional Study

Paediatrics in Barcelona

Physical exercise training for cystic fibrosis

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