Longitudinal Relationship Between Metabolic Syndrome and Periodontal Disease Among Japanese Adults Aged ≥70 Years: The Niigata Study

Iwasaki, Masanori; Sato, Misuzu; Minagawa, Kimino; Manz, Michael C.; Yoshihara, Akihiro; Miyazaki, Hideo

doi:10.1902/jop.2015.140398

Cited by 32 publications

(32 citation statements)

References 44 publications

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“…Several studies published subsequent to that review (Thanakun et al 2014;Iwasaki et al 2015;Minagawa et al 2015), but not all (LaMonte et al 2014), also reported significant associations. However, there was considerable variation in the periodontal disease measures and the definitions of MetS used, and few studies were prospective in design.…”

Section: Introductionmentioning

confidence: 92%

Metabolic Syndrome and Periodontal Disease Progression in Men

et al. 2016

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Metabolic syndrome, a cluster of 3 or more risk factors for cardiovascular disease, is associated with periodontal disease, but few studies have been prospective in design. This study's aim was to determine whether metabolic syndrome predicts tooth loss and worsening of periodontal disease in a cohort of 760 men in the Department of Veterans Affairs Dental Longitudinal Study and Normative Aging Study who were followed up to 33 y from 1981 to 2013. Systolic and diastolic blood pressures were measured with a standard mercury sphygmomanometer. Waist circumference was measured in units of 0.1 cm following a normal expiration. Fasting blood samples were measured in duplicate for glucose, triglyceride, and high-density lipoprotein. Calibrated periodontists served as dental examiners. Periodontal outcome events on each tooth were defined as progression to predefined threshold levels of probing pocket depth (≥5 mm), clinical attachment loss (≥5 mm), mobility (≥0.5 mm), and alveolar bone loss (≥40% of the distance from the cementoenamel junction to the root apex, on radiographs). Hazards ratios (95% confidence intervals) of tooth loss or a periodontitis event were estimated from tooth-level extended Cox proportional hazards regression models that accounted for clustering of teeth within individuals and used time-dependent status of metabolic syndrome. Covariates included age, education, smoking status, plaque level, and initial level of the appropriate periodontal disease measure. Metabolic syndrome as defined by the International Diabetes Federation increased the hazards of tooth loss (1.39; 1.08 to 1.79), pocket depth ≥5 mm (1.37; 1.14 to 1.65), clinical attachment loss ≥5 mm (1.19; 1.00 to 1.41), alveolar bone loss ≥40% (1.25; 1.00 to 1.56), and tooth mobility ≥0.5 mm (1.43; 1.07 to 1.89). The number of positive metabolic syndrome conditions was also associated with each of these outcomes. These findings suggest that the metabolic disturbances that comprise the metabolic syndrome may play a role in the development or worsening of periodontitis.

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Section: Introductionmentioning

confidence: 92%

Metabolic Syndrome and Periodontal Disease Progression in Men

et al. 2016

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“…, Iwasaki et al. ) have reported that individuals with MetS are more likely to have periodontal disease than those without MetS, suggesting that MetS contributes to the development of periodontal disease. Additionally, two cross‐sectional studies showed that MetS is associated with dental caries (Timonen et al.…”

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confidence: 99%

Tooth loss and metabolic syndrome in middle‐aged Japanese adults

Furuta

Liu

Shinagawa³

et al. 2016

J Clinic Periodontology

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“…Oxidative stress may add evidence to elucidate the mechanism of the relationship between systemic health conditions and periodontal disease 16) . Also, changes in environmental factors, eating habits, and life styles that influence obesity may affect the relationship between systemic health conditions and periodontal disease, as a component analysis of each systemic health conditions found abdominal girth in women had the strongest association with periodontal disease 10) .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, obesity was associated with tooth loss among elderly aged 70 years and over 1 [13][14][15] . Longitudinal studies also revealed a causal relationship that people with obesity were more likely to develop periodontal disease 16,17) .…”

Section: Introductionmentioning

confidence: 99%

“…The association between systemic health conditions and oral health has been examined in many studies [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] . Individuals with systemic health condition such as obesity, diabetes, hypertension, and hypercholesterolemia were found to have higher risk of developing periodontal disease than those without systemic health conditions [5][6][7][8][9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

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Association between Systemic Health Conditions and Self-Reported Oral Health in Korean Elderly

Choi

Lyu²,

Patton

et al. 2017

J Dent Hyg Sci

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Systemic health conditions increase with advancing age, and may be linked to poor self-reported oral health. The purpose of this study was to evaluate the association between systemic health conditions and poor self-reported oral health among Korean elderly. The study used a nationally representative sample of Koreans (2012 Korea National Health and Nutrition Examination Survey) aged 65∼98 years (n=1,595). Systemic health conditions in this population were assessed by the presence of one or more of the following conditions: obesity, hypertension, diabetes, and hypercholesterolemia. The relative risk of poor self-reported oral health according to the occurrence of systemic health conditions was estimated by multivariate logistic regression after controlling for several potential confounders (i.e., socio-demographic factors, oral health behaviors, health behaviors, and psychological factors). After adjustment for these confounders, the relative risk of having poor self-reported oral health was greater among the elderly with one or more systemic health conditions than in those without a systemic health condition. The odds ratio of having poor self-reported oral health according to the occurrence of systemic health conditions was 1.51 (95% confidence interval, 1.08∼2.12). Among the Korean elderly, perception of poor oral health was associated with the presence of one or more systemic health conditions. Future studies are needed to examine the detailed causal relation between systemic health conditions and poor oral health longitudinally.

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Longitudinal Relationship Between Metabolic Syndrome and Periodontal Disease Among Japanese Adults Aged ≥70 Years: The Niigata Study

Abstract: These findings support the hypothesis that MetS may be a risk factor for periodontal disease in older Japanese individuals. Additional studies with larger, more diverse populations and more complete information are needed to substantiate the findings.

Cited by 32 publications

References 44 publications

Metabolic Syndrome and Periodontal Disease Progression in Men

Metabolic Syndrome and Periodontal Disease Progression in Men

Tooth loss and metabolic syndrome in middle‐aged Japanese adults

Association between Systemic Health Conditions and Self-Reported Oral Health in Korean Elderly

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