Longitudinal multicompartment characterization of host-microbiota interactions in patients with acute respiratory failure
Georgios D. Kitsios,
Khaled Sayed,
Adam Fitch
et al.
Abstract:Critical illness can significantly alter the composition and function of the human microbiome, but few studies have examined these changes over time. Here, we conduct a comprehensive analysis of the oral, lung, and gut microbiota in 479 mechanically ventilated patients (223 females, 256 males) with acute respiratory failure. We use advanced DNA sequencing technologies, including Illumina amplicon sequencing (utilizing 16S and ITS rRNA genes for bacteria and fungi, respectively, in all sample types) and Nanopor… Show more
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