Longitudinal Intergenerational Birth Cohort Designs: A Systematic Review of Australian and New Zealand Studies

Townsend, Michelle L.; Riepsamen, Angelique H; Georgiou, Christos D.; Flood, Victoria M; Caputi, Peter; Wright, Ian; Davis, Warren S.; Jones, Alison L; Larkin, Theresa A; Williamson, Moira; Grenyer, Brin F. S.

doi:10.1371/journal.pone.0150491

Cited by 21 publications

(19 citation statements)

References 123 publications

(130 reference statements)

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“…According to the 2000 U.S. census data, the Olmsted County population is comparable to the overall U.S. population with respect to median age (35.0 y vs. 35.3 y) and male gender (49.1% vs. 49.1%). The ethnic characteristics of this population (87.6% white in Olmsted County, MN) are similar to other upper Midwest states (90.2% white in North and South Dakota, Iowa, and Wisconsin) (35). Compared to the entire US population, whites are more prevalent (87.6%vs.…”

Section: Discussionsupporting

confidence: 64%

Epidemiology of Pediatric Critical Illness in a Population-Based Birth Cohort in Olmsted County, MN

Crow¹,

Undavalli

Warner³

et al. 2017

Pediatric Critical Care Medicine

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Objectives Investigations of pediatric critical illness typically focus on inpatient cohorts drawn from wide referral areas and diverse healthcare systems. Cohorts amenable to investigating the full spectrum of critical illness as it develops within a community have yet to be studied in the US. Our objective was to provide the first epidemiologic report of the incidence and presentation of pediatric critical illness within a US population-based birth cohort. Design Retrospective cohort study Setting and Patients We investigated a birth cohort of children (n=9,441) born 2003–2007 within a geographically defined area (Olmsted County, MN). Medical records are linked across all health systems accessed by this population. All intensive care unit (ICU) services are provided within a single children’s hospital. Measurements and Main Results During the study period, there were a total of 15,277 ICU admissions to Mayo Clinic Children’s Hospital. A total of 577 birth cohort children accounted for 824 of these admissions during the 61,770 person-years of follow-up accumulated. Incidence of first-time ICU admission was 9.3 admits per 1,000 person-years. Admission rates were highest in the first year of life and then declined steadily. Respiratory problems were among the most common reasons for admission at any age and diagnoses reflect changes in health risk factors as children grow and develop over time. After 1 year of age, a majority of children admitted have pre-existing chronic comorbidities and/or prior ICU stays. In-hospital mortality occurred exclusively in children admitted prior to 5 days of age (n=4). Seven children died after hospital discharge. Conclusions This is the first report characterizing critical illness within a population-based birth cohort of US children. The results demonstrate the changing incidence, presentation, and healthcare requirements associated with critical illness across the developmental spectrum as a population of children ages.

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Section: Discussionsupporting

confidence: 64%

Epidemiology of Pediatric Critical Illness in a Population-Based Birth Cohort in Olmsted County, MN

Crow¹,

Undavalli

Warner³

et al. 2017

Pediatric Critical Care Medicine

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“…A recent systematic review of longitudinal birth cohort studies in Australia and New Zealand reported a median of 1095 mothers across 23 studies [14]. Therefore, for this feasibility study, a target sample of 55 women (5%) was deemed suitable.…”

Section: Acceptability Of the Research Protocolmentioning

confidence: 99%

“…The Lifeways Cross-Generation Cohort Study [13]). This multi-generational, longitudinal approach allows for the exploration of inter-generational differences and supports a focus on the contributions of genetics, environment and lifestyle, on general health and wellbeing and other specific traits [14]. Pregnancy is a time of excitement, anticipation, adjustment, stress and anxiety for parents [15].…”

Section: Introductionmentioning

confidence: 99%

“…This is an innovative design and provides the opportunity to simultaneously study nested cross-sectional variables within a genetic-variant family and compare between and across generations within the same study period and at longitudinal time points. Longitudinal cohort studies of individuals provide the best tool to obtain high-quality evidence for the determinants of health, by allowing the relationships between events, characteristics and subsequent outcomes to be identified and evaluated [14]. Most cohort studies follow one group of individuals (sometimes two) [18]; however, this project will be one of very few studies that follow an extended family unit over time.…”

Section: Introductionmentioning

confidence: 99%

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Illawarra Born cross-generational health study: feasibility of a multi-generational birth cohort study

Townsend

Kelly

Pickard

et al. 2019

Pilot Feasibility Stud

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Background There is a strong interest in the concept of developmental origins of health and disease and their influence on various factors “from cradle to grave”. Despite the increasing appreciation of this lifelong legacy across the human life course, many gaps remain in the scientific understanding of mechanisms influencing these formative phases. Cross-generational susceptibility to health problems is emerging as a focus of research in the context of birth cohort studies. The primary aim of the Illawarra Born study is to make scientific discoveries associated with improving health and wellbeing across the lifespan, with a particular focus on preventable chronic diseases, especially mental health. This birth cohort study will follow and collect data from three cohorts representing different stages across the lifespan: infants, adults (parents) and older adults (grandparents). The multi-generational, cross-sectional and longitudinal design of this birth cohort study supports a focus on the contributions of genetics, environment and lifestyle on health and wellbeing. The feasibility of conducting a multi-generational longitudinal birth cohort project was conducted through a small pilot study. Methods/design The purpose of this paper is to report on the feasibility and acceptability of the research protocol for a collaborative cross-generation health study in the community and test recruitment and outcome measures for the main study. This feasibility study included pregnant women who were intending to give birth in the Illawarra-Shoalhaven region in Eastern Australia. The area includes a large, regional referral hospital, with capacity to treat specialist and complex cases. Pregnant women were asked to participate in five data collection waves beginning at 22 weeks gestation and ending with a 6-month post-partum appointment. Recruitment was then extended, via the pregnant women, to also include fathers and maternal grandmothers. Discussion This feasibility study focused on the perinatal period and collected data across three multi-disciplinary domains including mental health, diet, exposures to toxins and the role of these in maternal and infant outcomes. Forty-one families participated in extensive data collection from 22 weeks gestation to 6-months post-partum. Factors impacting on viability and feasibility including recruitment solutions provide the basis for a large-scale study.

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“…Longitudinal cohort studies with large populations have multiple benefits, including being able to plot prevalence at different time points, study temporal changes and associations with a range of factors. As well as addressing current research questions and informing policy, participants can also be a resource for the future . While cohort studies can fulfil the interests of researchers, policy makers and clinicians, participants are seldom listed as beneficiaries.…”

Section: Introductionmentioning

confidence: 99%

Stop, think, reflect, realize—first‐time mothers’ views on taking part in longitudinal maternal health research

Daly

Carroll

Barros

et al. 2019

Health Expectations

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Background Longitudinal cohort studies gather large amounts of data over time, often without direct benefit to participants. A positive experience may encourage retention in the study, and participants may benefit in unanticipated ways. Objective To explore first‐time mothers’ experiences of taking part in a longitudinal cohort study and completing self‐administered surveys during pregnancy and at 3, 6, 9 and 12 months’ postpartum. Design Content analysis of comments written by participants in the Maternal health And Maternal Morbidity in Ireland study's five self‐completion surveys, a multisite cohort study exploring women's health and health problems during and after pregnancy. This paper focuses on what women wrote about taking part in the research. Ethical approval was granted by the site hospitals and university. Setting and participants A total of 2174 women were recruited from two maternity hospitals in Ireland between 2012 and 2015. Findings A total of 1000 comments were made in the five surveys. Antenatally, barriers related to surveys being long and questions being intimate. Postpartum, barriers related to being busy with life as first‐time mothers. Benefits gained included gaining access to information, taking time to reflect, stopping to think and being prompted to seek help. Survey questions alone were described as valuable sources of information. Discussion and conclusions Findings suggest that survey research can “give back” to women by being a source of information and a trigger to seek professional help, even while asking sensitive questions. Understanding this can help researchers construct surveys to maximize benefits, real and potential, for participants.

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Longitudinal Intergenerational Birth Cohort Designs: A Systematic Review of Australian and New Zealand Studies

Cited by 21 publications

References 123 publications

Epidemiology of Pediatric Critical Illness in a Population-Based Birth Cohort in Olmsted County, MN

Epidemiology of Pediatric Critical Illness in a Population-Based Birth Cohort in Olmsted County, MN

Illawarra Born cross-generational health study: feasibility of a multi-generational birth cohort study

Stop, think, reflect, realize—first‐time mothers’ views on taking part in longitudinal maternal health research

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