2002
DOI: 10.1364/oe.10.000035
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Longitudinal imaging in biological tissues with a single laser shot correlation system

Abstract: We demonstrate the potential of a new optical imaging system to directly obtain a longitudinal slice of a biological sample. The system, based on a single-shot optical correlator, operates a time-to-space conversion and an optical time-gating by sum-frequency generation in a nonlinear crystal. Owing to the high speed acquisition of the technique, internal structures of in-vivo tissues can be imaged at video rate.With this apparatus, we recorded longitudinal images of ex vivo mouse ear and in vivo human skin wi… Show more

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Cited by 16 publications
(8 citation statements)
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“…The method, which has been already published in previous paper 5,6 , is based on so-called "time-gating" imaging which discriminates between early ballistic photons and time-delayed scattered photons. By selecting the ballistic photons, which did not experience any diffusion process in the sample, it becomes possible to obtain a clear image of the internal structures of the sample.…”
Section: Operating Principlementioning
confidence: 99%
“…The method, which has been already published in previous paper 5,6 , is based on so-called "time-gating" imaging which discriminates between early ballistic photons and time-delayed scattered photons. By selecting the ballistic photons, which did not experience any diffusion process in the sample, it becomes possible to obtain a clear image of the internal structures of the sample.…”
Section: Operating Principlementioning
confidence: 99%
“…They use a fast photoelastic birefringence modulator to introduce sinusoidal phase shift between sample and reference lights, and four images with different phase shifts were thus recorded successively to reconstruct the enface OCT image. En-face OCT imaging using conventional sequentional phase shifting with the reference mirror by PZT is realized by several authors [5][6][7][8][9].…”
Section: Introductionmentioning
confidence: 99%
“…For example, the depth resolution of gated imaging systems with short laser pulses could be enhanced with the aid of non-linear crystal. Bordenave et al [13] in 2002 achieved a 15 µm depth resolution in their imaging system with femto-seconds laser pulses. They used pulsed laser synchronization with a multiple quantum well structure, but it allows only longitudinal depth mapping.…”
Section: Introductionmentioning
confidence: 99%