Longitudinal genomic alternations and clonal dynamics analysis of primary malignant melanoma of the esophagus

Li, Jingjing; Guan, Wenyan; Ren, Wei; Liu, Ziyao; Wu, Hongyan; Chen, Yiqiang; Liu, Siyuan; Quan, Xin; Yang, Zuoquan; Jiang, Chong; He, Jian; Xiao, Xiao; Ye, Qing

doi:10.1016/j.neo.2022.100811

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…1 It is estimated that just about 480 cases of PMME have been reported since the first case was described by Baur in 1906, with .90% located in the middle and lower thirds of the esophagus. 7 There are no clearly defined environmental exposures that are associated with PMME, with only indirect causality attributed to smoking cigarettes in some of the cases. PMMEs are thought to be twice as common in male patients as in female patients, occurring mostly in the 6th and 7th decade of life.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Primary Malignant Melanoma of the Esophagus Presenting as Dysphagia

Chaudhry,

Buluku,

Noor

et al. 2024

ACG Case Rep J

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Melanoma is one of the most notorious tumors due to its appearance in unusual locations. The most frequent site is the skin; however, it can sporadically develop as a primary tumor in the esophagus. However, as symptoms appear later, if the primary site is in the gastrointestinal system, it is frequently detected at the metastatic stage. We hereby describe a case of primary malignant melanoma of the esophagus that presented due to dysphagia with solid food and on further workup, found to be at the metastatic stage.

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Section: Discussionmentioning

confidence: 99%

A Rare Case of Primary Malignant Melanoma of the Esophagus Presenting as Dysphagia

Chaudhry,

Buluku,

Noor

et al. 2024

ACG Case Rep J

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Primary malignant melanoma of the esophagus: A case report

Wang¹,

Li²,

Geng³

et al. 2023

World J Clin Cases

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Primary malignant melanoma of the esophagus (PMME) is a malignant tumor which occurs in the melanin cells of esophageal mucosal epithelial basal layer. PMME is a rare disease with an extremely poor prognosis. PMME represents only 0.1% to 0.2% of all esophageal malignant tumors. Dysphagia, retrosternal or epigastric discomfort or pain is the most frequent symptom at presentation. Retrosternal, epigastric discomfort, melena or hematemesis are the major clinical manifestations. The tumor is often located from the middle to lower thoracic esophagus. The characteristic endoscopic finding of PMME is a polypoid lesion that is usually pigmented. Immunohistochemical examination with positive results of S100 protein, HMB45 and neuron-specific enolase allow a definitive diagnosis. PMME metastasizes via hematogenic and lymphatic pathways. Esophagectomy is believed to be an effective approach for localized PMME. Five-year survival rates of 37% or higher have been achieved recently. Herein, we report a case of an 65-year-old female admitted for progressive difficulty in swallowing for more than 4 mo. After upper gastrointestinal endoscopy and biopsy, upper gastrointestinal series and computed tomography examination, the patient accepted radical esophagectomy, and the postoperative pathologic and immunohistochemical examination showed PMME.

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Longitudinal genomic alternations and clonal dynamics analysis of primary malignant melanoma of the esophagus

Cited by 2 publications

References 30 publications

A Rare Case of Primary Malignant Melanoma of the Esophagus Presenting as Dysphagia

A Rare Case of Primary Malignant Melanoma of the Esophagus Presenting as Dysphagia

Primary malignant melanoma of the esophagus: A case report

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