Longitudinal follow-up of the relationship between dietary intake and growth and development in the Lifeways cross-generation cohort study 2001–2013

Kelleher, Cecily; Viljoen, Karien; Khalil, Hala; Somerville, R.; O’Brien, John; Shrivastava, Aakash; Murrin, Celine

doi:10.1017/s002966511300373x

Cited by 27 publications

(29 citation statements)

References 116 publications

(152 reference statements)

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“…Child health outcomes include wheeze and asthma as well as obesity. 15 The ACROSSOLAR study is recruiting children born to ~2000 participants of the International Study of Asthma and Allergies in Childhood (ISAAC) study in Germany. 16 Information is collected regarding pregnancy conditions, and asthma and allergic health status of the child up to primary school age.…”

Section: Multigenerational Cohortsmentioning

confidence: 99%

Multigenerational cohorts in patients with asthma and allergy

Arshad

Karmaus

Zhang

et al. 2017

Journal of Allergy and Clinical Immunology

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Recent observations that disease risk can be transmitted across generations, without the need for a direct exposure of the child to the index environmental insult, has sparked interest in transgenerational inheritance. Epigenetic describes processes that modify gene expression without a change in the nucleotide sequence. Epigenetic processes can be induced in response to environmental exposures and can influence disease risk, and may explain these multigenerational effects. In experimental models, a number of epigenetic mechanisms have been identified that could mediate vertical transmission of epigenetic inheritance. However, relevance of these findings to human disease is not yet clear. An alternative model is where transgenerational inheritance of disease risk requires the presence of exposure-related diseases in the mother during pregnancy (termed 'induced epigenetic transmission model').A number of cross-sectional studies have investigated multigenerational effects in allergy and asthma. However, given early life origins of asthma and allergy, birth cohort studies are ideal to investigate the impact of genetic predisposition, epigenetics, and environmental exposures avoiding pitfalls such as recall bias and confounding by ongoing exposures, disease and treatment. The well characterized, three generations of the Isle of Wight cohort includes two consecutive birth cohorts, providing longitudinal data that can be studied for epigenetic transfer of information, e.g., the effect of grand parental smoking or exposure to other toxic compounds. Further large multigenerational birth cohorts are needed to establish the clinical relevance of this phenomenon and differentiate between vertical and induced transmission models, which may influence future preventive strategies.

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Section: Multigenerational Cohortsmentioning

confidence: 99%

Multigenerational cohorts in patients with asthma and allergy

Arshad

Karmaus

Zhang

et al. 2017

Journal of Allergy and Clinical Immunology

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“…15 The MGM may in turn be associated with both BMI of daughter and that of grandchild. 9,10 It is possible this path is mediated through IBW. Another explanation for the findings here is a clustering for risk of elevated BMI in families, with age, education and lineage, all playing a role both in determining IBW and adult BMI.…”

Section: Discussionmentioning

confidence: 99%

“…The Lifeways cross-generation cohort study was established in 2001 and its methodology has been described previously. 8,9 In brief, expectant mothers were recruited in two maternity hospitals in the East and West of Ireland during first hospital booking visit and at baseline completed a questionnaire. They were asked to include in the study their proband infant, the father if available and at least one of four potential grandparents.…”

Section: Methodsmentioning

confidence: 99%

“…The Lifeways cross-generational cohort study was designed a priori to examine associations across generations and it affords the opportunity of relating birth weight in cohort members to measures of health status across the life course. [8][9][10][11][12] It is one of the very few studies with three generations followed prospectively. In previous published analyses we have shown that BMI in children at three age points is consistently associated with BMI in the adult maternal line, whereas height shows associations in both lineages.…”

Section: Introductionmentioning

confidence: 99%

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Predictors of adults’ body mass index and the association with index child’s infant birth weight, in the Lifeways Cross-Generation Cohort Study of a thousand families in the Republic of Ireland

McKey

Heinen

Mehegan

et al. 2017

J Dev Orig Health Dis

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The Lifeways study is novel in having information on three generations of the same families. It is well established that infant birth weight (IBW) predicts individuals' risk of adult chronic disease and more recently studies report cross-generation transmission of risk patterns. The aims of this analysis were to examine whether adults' birth weights were associated with measures of own health status or social position and to relate adults' birth weights to that of the index child's IBW. Finally, we assessed whether birth weight of either adults or children was associated with adult body mass index (BMI) of parents and grandparents. We included 1075 children whose IBW was recorded at recruitment from hospital records and 2546 adult cohort members followed from 2001 until 2014. At baseline, a sub-group of 920 adults had reported own birth weight (RBW). Results showed male adults' RBW were significantly higher than females' (P=0.001). Mothers' RBW was significantly correlated with IBW (r=0.178, P<0.001). In mixed effects linear models with BMI as the outcome variable, of all adults, and in sub-groups of adults with RBW and of mothers only, the IBW was associated with adult BMI adjusting for other predictors. Adults' BMI was positively associated with age (P=0.013), index child's IBW (P=0.001), gender (P<0.001) but not own RBW, adjusting for family identification number. When mothers were removed from the adult models however, IBW ceased to be associated with BMI, a final model showed RBW being associated with adult BMI (P=0.04). There are cross-generational associations in the Lifeways cohort, the maternal association being stronger.

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“…Based in the Republic of Ireland, the Lifeways Cross-Generation Cohort Study recruited 1100 pregnant women in 2001 and is one of very few worldwide containing data on grandparents of both lineages (Kelleher et al 2014). The children have been followed up at age 5 and 9 years, with physical examinations and linkage to hospital data and general practice records.…”

Section: The Lifeways Cross-generation Cohort Studymentioning

confidence: 99%

Early‐life dietary and epigenetic influences on childhood musculoskeletal health: Update on the UK component of the ALPHABET project

Curtis

Suderman²,

Phillips

et al. 2018

Nutrition Bulletin

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The ALPHABET project, funded through the European Research Area Healthy Diet for a Healthy Life Biomarkers call, aims to expand the knowledge base regarding interactions between diet, epigenetics and offspring health, characterising biomarkers that may inform future health strategies. This review focuses on the UK Biotechnology and Biological Sciences Research Council (BBSRC)‐funded component in which the aim was to (1) generate and collate early‐life epigenetic data and (2) investigate early diet and epigenetic marks as predictors of later bone health. The project builds on a wealth of evidence implicating environmental factors, such as maternal diet and body composition, as influences on the long‐term health and development of the offspring, and that these relationships might be mediated at least in part through epigenetic signals. Experimental studies in animal models have demonstrated that manipulation of maternal diet during pregnancy leads to altered offspring epigenetic marking and phenotype. Human studies convincingly demonstrate associations between early environment and later health and disease for outcomes across musculoskeletal, respiratory, neurodevelopmental and cardiometabolic health. The priority now is to find ways in which such observations can be translated into improved lifelong health. A key approach is to identify early biomarkers of adverse health outcomes and then to test these, and subsequent interventions, in trials aimed at identifying strategies to optimise health throughout the life course. The ALPHABET project will inform this process for musculoskeletal outcomes, and the project as a whole should help elucidate not only novel mechanisms, but also potential strategies to reduce the burden of musculoskeletal, respiratory, neurodevelopmental and cardiometabolic disease in future generations.

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Longitudinal follow-up of the relationship between dietary intake and growth and development in the Lifeways cross-generation cohort study 2001–2013

Cited by 27 publications

References 116 publications

Multigenerational cohorts in patients with asthma and allergy

Multigenerational cohorts in patients with asthma and allergy

Predictors of adults’ body mass index and the association with index child’s infant birth weight, in the Lifeways Cross-Generation Cohort Study of a thousand families in the Republic of Ireland

Early‐life dietary and epigenetic influences on childhood musculoskeletal health: Update on the UK component of the ALPHABET project

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