Longitudinal field survey during deployment of an emergency autogenous vaccine against Betanodavirus in farmed giant grouper (Epinephelus lanceolatus): Multiple factors contribute to outbreaks and survival

Thwaite, Rosemary; Li, Angus; Kawasaki, Minami; Lin, Chun-han; Stephens, Frances; Cherrie, Brad; Knuckey, Richard; Landos, Matt; Barnes, Andrew C.

doi:10.1016/j.aquaculture.2021.737599

Cited by 3 publications

(4 citation statements)

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“…formulated leading to immune compromise. 36 Finally, agriculture and urban water that are indirectly connected through shared water resource that may adversely impact the water available to the farm in terms of quantity (leading to inadequate water exchange and resulting hypoxia) and quality. Indeed, many pesticides and other pollutants are known to suppress the immune systems of aquatic organisms leading to disease.…”

Section: Overview Of Tilapia Aquaculture Diseases and Importance Of D...mentioning

confidence: 99%

“…There are many human impacts on farm animal health. These include actions of the farmer such as water management, animal handling, stocking practice, feed storage and feeding regimes 35,36 . There are directly connected actors such as feed companies, where diet provided to farms may not be optimally formulated leading to immune compromise 36 .…”

Section: Overview Of Tilapia Aquaculture Diseases and Importance Of D...mentioning

confidence: 99%

“…These include actions of the farmer such as water management, animal handling, stocking practice, feed storage and feeding regimes 35,36 . There are directly connected actors such as feed companies, where diet provided to farms may not be optimally formulated leading to immune compromise 36 . Finally, agriculture and urban water that are indirectly connected through shared water resource that may adversely impact the water available to the farm in terms of quantity (leading to inadequate water exchange and resulting hypoxia) and quality.…”

Section: Overview Of Tilapia Aquaculture Diseases and Importance Of D...mentioning

confidence: 99%

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From the basics to emerging diagnostic technologies: What is on the horizon for tilapia disease diagnostics?

Dong

Chaijarasphong

Barnes

et al. 2023

Reviews in Aquaculture

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Tilapia is an affordable protein source farmed in over 140 countries with the majority of production in low‐ and middle‐income countries. Intensification of tilapia farming has exacerbated losses caused by emerging and re‐emerging infectious diseases. Disease diagnostics play a crucial role in biosecurity and health management to mitigate disease loss and improve animal welfare in aquaculture. Three continuous levels of diagnostics (I, II and III) for aquatic species have been proposed by Food and Agriculture Organization of the United Nations (FAO) and the Network of Aquaculture Centers in Asia and the Pacific (NACA) to promote the integration of basic and advanced methods to achieve accurate and meaningful interpretation of diagnostic results. However, the recent proliferation of cutting‐edge molecular methods applied in the diagnosis of diseases of aquacultured animals has shifted the focus of researchers and users away from basic approaches and toward molecular diagnostics, despite the fact that many diseases can be rapidly diagnosed using inexpensive, simple microscopic examination and that most emerging diseases in aquaculture were discovered by histopathology. This review, therefore, revisits and highlights the importance of the three levels of diagnostics for diseases of tilapia, particularly the frequently overlooked basic procedures (e.g., case history records, gross pathology, presumptive diagnostic methods and histopathology). The review also covers current and emerging molecular diagnostic technologies for tilapia pathogens including polymerase chain reaction methods (conventional, quantitative, digital), isothermal amplification methods Loop‐mediated Isothermal Amplification (LAMP), recombinase polymerase amplification (RPA), clustered regularly interspaced short palindromic repeats (CRISPR)‐based detection, lateral flow immunoassays, as well as discussing what is on the horizon for tilapia disease diagnostics (next generation sequencing, artificial intelligence, environmental Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) and point‐of‐care testing) providing a future vision for transferring these technologies to farmers and stakeholders for a sustainable aquatic food system transformation.

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Section: Overview Of Tilapia Aquaculture Diseases and Importance Of D...mentioning

confidence: 99%

Section: Overview Of Tilapia Aquaculture Diseases and Importance Of D...mentioning

confidence: 99%

Section: Overview Of Tilapia Aquaculture Diseases and Importance Of D...mentioning

confidence: 99%

See 1 more Smart Citation

From the basics to emerging diagnostic technologies: What is on the horizon for tilapia disease diagnostics?

Dong

Chaijarasphong

Barnes

et al. 2023

Reviews in Aquaculture

Self Cite

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“…Philasterides dicentrarchi). Viruses are not routinely considered as candidates for fish autogenous vaccines; however, several manufacturers have produced and applied viral autogenous vaccines in aquaculture (Barnes et al, 2021, Thwaite et al, 2022.…”

Section: Selection Of Pathogen Candidates For Autogenous Vaccine Deve...mentioning

confidence: 99%

Autogenous vaccines in aquaculture: Tool to combat resistance of bacteria to antibiotics?

Palić

Aksentijević

2022

VET GLASNIK

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New technological progress and increased demands for fish as a source of animal protein are driving significant growth of aquaculture production. Intensification of production increases the severity and frequency of infectious disease outbreaks, and so requires significant effort to prevent and control disease. Because of the global crisis of bacterial resistance to antibiotics, the use of antibiotics in aquaculture is increasingly subjected to strict control and regulatory measures, leading to potential misuse. The lack of availability of approved veterinary medical products for use in aquaculture, combined with the risk of drug resistance development and antibiotic residues in fish flesh or water, support the development of preventive actions, including vaccines. However, the diversity of species and aquaculture production methods, including epidemiological units and their links, results in economic challenges for commercial vaccine development and authorization. As a possible response to the increasing demand for less antibiotic use in fish farms, and to the expenses associated with novel veterinary product development, there is a need for increased use of safe and effective autogenous vaccines in aquaculture. Regulatory processes for autogenous vaccine production, approval and application should recognize the specificities of epidemiological units and their links in aquatic animal production facilities. The joint efforts of regulatory authorities, producers, and veterinary services to follow veterinary biosecurity principles, including risk analysis, surveillance, and selection/prioritization of pathogens, are essential to provide maximum safety and efficacy of autogenous vaccines as disease prevention and control tools within larger areas, such as compartments and zones, and allow for reductions in antibiotic use.

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Nervous Necrosis Virus (NNV) Booster Vaccination Increases Senegalese Sole Survival and Enhances Immunoprotection

López-Vázquez

Souto

Olveira

et al. 2022

Animals

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A re-immunization programme has been tested to improve the protective response elicited in sole by a previously developed BEI-inactivated betanodavirus vaccine. The vaccine was prepared using a reassortant RGNNV/SJNNV strain which is highly pathogenic for sole, and vaccination assays were performed by intraperitoneal injection. Experimental design included a prime- and a booster-vaccination group, which consisted of individuals that received a second vaccine injection at 30 days post vaccination), and their respective controls. A month after prime/booster vaccination, fish were challenged by intramuscular injection with the homologous NNV strain. Samples were collected at different times post vaccination and post challenge to assess the immune response and viral replication. Booster dose enhanced the protection against NNV infection because a significant increase in survival was recorded when compared with prime-vaccinated individuals (relative percent survival 77 vs. 55). In addition, a clear decrease in viral replication in the brain of challenged sole was observed. During the immune induction period, no differences in IgM production were observed between prime- and booster-vaccinated fish, and the expression of the antigen presenting cells (APC)-related molecule MHC class II antigen was the only differential stimulation recorded in the re-immunized individuals. However, a significant upregulation of mhcII and the lymphocytes T helper (Th) marker cd4 was observed after the challenge in the booster-vaccinated group, suggesting these cells play a role in the protection conferred by the booster injection. In addition, after viral infection, re-immunized fish showed specific and neutralizing antibody production and overexpression of other immune-related genes putatively involved in the control of NNV replication.

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Longitudinal field survey during deployment of an emergency autogenous vaccine against Betanodavirus in farmed giant grouper (Epinephelus lanceolatus): Multiple factors contribute to outbreaks and survival

Cited by 3 publications

References 56 publications

From the basics to emerging diagnostic technologies: What is on the horizon for tilapia disease diagnostics?

From the basics to emerging diagnostic technologies: What is on the horizon for tilapia disease diagnostics?

Autogenous vaccines in aquaculture: Tool to combat resistance of bacteria to antibiotics?

Nervous Necrosis Virus (NNV) Booster Vaccination Increases Senegalese Sole Survival and Enhances Immunoprotection

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