Longitudinal extent of lipid pool assessed by optical coherence tomography predicts microvascular no-reflow after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

Ikenaga, Hiroki; Ishihara, Masaharu; Inoue, Ichiro; Kawagoe, Takuji; Sakai, Yuji; Miura, Fumiharu; Nakama, Yasuharu; Dai, Kazuoki; Ohtani, Takayuki; Ohi, Kuniomi; Miki, Takashi; Nakamura, Masayuki; Kishimoto, Seiji; Sumimoto, Yoji; Kihara, Yasuki

doi:10.1016/j.jjcc.2013.03.005

Cited by 27 publications

(16 citation statements)

References 41 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1). To differentiate thrombi from plaque protrusion or neointimal hyperplasia, we excluded protruding masses without remarkable signal attenuation and surface irregularity [8,9].…”

Section: Oct Analysismentioning

confidence: 99%

Impact of hemodialysis on local vessel healing and thrombus formation after drug-eluting stent implantation

Konishi

Shinke

Otake

et al. 2014

Journal of Cardiology

View full text Add to dashboard Cite

show abstract

“…1). To differentiate thrombi from plaque protrusion or neointimal hyperplasia, we excluded protruding masses without remarkable signal attenuation and surface irregularity [8,9].…”

Section: Oct Analysismentioning

confidence: 99%

Impact of hemodialysis on local vessel healing and thrombus formation after drug-eluting stent implantation

Konishi

Shinke

Otake

et al. 2014

Journal of Cardiology

View full text Add to dashboard Cite

show abstract

“…Advanced heart failure was defined by the New York Heart Association (NYHA) functional classification of ≥3 (14). ST-segment resolution (ST-R) in the electrocardiogram reflects micro-reperfusion that was defined as a >50% decrease in ST elevation at the lead in which ST segment elevation was greatest on the electrocardiogram completed on arrival, 1 h following the primary PCI (15). Micro-reperfusion was defined as a >50% decrease in ST elevation at the lead in which ST segment elevation was greatest on the initial electrocardiogram 1 h following the primary PCI.…”

Section: Methodsmentioning

confidence: 99%

Fragmented QRS complex is a prognostic marker of microvascular reperfusion and changes in LV function occur in patients with ST elevation myocardial infarction who underwent primary percutaneous coronary intervention

Zhang

Chen

Zhao

et al. 2017

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

The present study aimed to investigate the in-hospital and long-term prognostic value of fragmented QRS complex (fQRS) for microvascular reperfusion and changes in left ventricular (LV) function in patients with ST elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI). A total of 216 patients with STEMI undergoing primary PCI were included in the current study. Patients were divided into two groups based on the presence (n=126) or absence (n=90) of fQRS following electrocardiograms (ECGs) on admission. Following primary PCI and follow up, patients were divided into four groups based on new onset, resolution, persistence and absence of fQRS. Major adverse cardiac events were defined to include cardiovascular death, arrhythmia, heart failure, reinfarction and target vessel revascularization. The percentage of patients with heart failure and microvascular reperfusion differed significantly between the fQRS(+) and fQRS(−) groups. Levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), Peak creatine kinase-MB (CK-MB) and Troponin I levels were observed to be significantly higher in the fQRS(+) group compared with the fQRS(−) group. In univariate logistic regression analysis, left ventricular ejection fraction (LVEF), NT-proBNP, Troponin I, Peak CK-MB and microvascular reperfusion were found to be associated with fQRS. Multivariate analysis identified that LVEF, NT-proBNP, Troponin I and microvascular reperfusion may be independent predictors of fQRS. The presence of fQRS was demonstrated to be associated with left ventricular dysfunction at follow up assessments. The presence of fQRS was not only significantly associated with myocardial microvascular reperfusion and left ventricular function, but was also a prognostic marker in STEMI.

show abstract

“…Recent OCT studies have shown that some vulnerable findings (lipid-rich plaque, TCFA, and spotty calcification) are predictors of no-reflow phenomenon. Ikenaga et al showed that length of lipid pool was longer in the ST-segment resoluton (−) group than in the ST-segment resoluton (+) group in patients with ST elevation myocardial infarction (10.1 ± 2.8 mm and 7.8 ± 3.2 mm, p = 0.02) [40]. Lee et al showed that TCFA was associated with cardiac troponin I elevation after PCI and the presence of TCFA was an independent predictor of periprocedural myocardial infarction (odds ratio, 10.47; 95% confidence interval, 3.74-29.28; P < 0.001) [39].…”

Section: Relationship Vulnerable Plaque By Oct and No-reflow Phenomenonmentioning

confidence: 98%

Optical Coherence Tomography for the Assessment of Coronary Plaque Vulnerability

Hasegawa¹,

Shimada²

2015

Coronary Artery Disease - Assessment, Surgery, Prevention

View full text Add to dashboard Cite

Optical coherence tomography OCT is a high-resolution imaging technology, which can provide detailed observation of the vulnerable coronary atherosclerotic plaques in clinical settings. The current understanding of the major cause of acute coronary syndrome is that it results from plaque rupture of a vulnerable plaque. OCT can provide detailed observation of the vulnerable coronary plaque. The main findings of vulnerable plaque by OCT are considered to be a lipid-rich plaque, a thin-cap fibroatheroma, microchannel structure, spotty calcification, macrophage infiltration, and cholesterol crystal. These features observed by OCT can provide cardiologists to consider pathological mechanisms of coronary atherosclerosis and suitable medical and interventional treatments for vulnerable patients. In this review, we will discuss the characteristics of OCT assessment for coronary atherosclerosis and the clinical impacts of OCT imaging for the treatment of coronary artery disease.

show abstract

Longitudinal extent of lipid pool assessed by optical coherence tomography predicts microvascular no-reflow after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

Abstract: These findings suggest that length of lipid pool estimated by OCT may predict microvascular no-reflow after primary PCI.

Cited by 27 publications

References 41 publications

Impact of hemodialysis on local vessel healing and thrombus formation after drug-eluting stent implantation

Impact of hemodialysis on local vessel healing and thrombus formation after drug-eluting stent implantation

Fragmented QRS complex is a prognostic marker of microvascular reperfusion and changes in LV function occur in patients with ST elevation myocardial infarction who underwent primary percutaneous coronary intervention

Optical Coherence Tomography for the Assessment of Coronary Plaque Vulnerability

Contact Info

Product

Resources

About