Longitudinal extensive transverse myelitis with cervical epidural haematoma following dengue virus infection

Fong, Choong Yi; Hlaing, Chaw Su; Tay, Chee Geap; Kadir, Khairul Azmi Abdul; Goh, Khean Jin; Ong, Lai Choo

doi:10.1016/j.ejpn.2016.01.012

Cited by 24 publications

(19 citation statements)

References 18 publications

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“…In addition, inflammatory reactions in the CSF are found in most patients. TM/LETM in dengue is rarely encountered, and no more than 12 case reports are available (Renganathan et al, 1996 ; Leao et al, 2002 ; Kunishige et al, 2004 ; Seet et al, 2006 ; Chanthamat and Sathirapanya, 2010 ; Verma et al, 2011a ; Larik et al, 2012 ; Singh et al, 2013 ; Weeratunga et al, 2014a ; Fong et al, 2016 ; Mo et al, 2016 ; Mota et al, 2017 ).…”

Section: Central Neurological System Complicationsmentioning

confidence: 99%

Section: Central Neurological System Complicationsmentioning

confidence: 99%

“…Treatment with intravenous steroids is useful, and individuals with parainfectious-dengue TM show satisfactory recovery (Fong et al, 2016 ). Fong et al reported that a previously healthy 12-year-old girl with parainfectious-dengue TM and concomitant spinal epidural haematoma had good clinical recovery without surgical intervention after 6 months (Fong et al, 2016 ). It was shown that post-infection autoimmune reactions and direct infection are associated with transverse myelitis (Solomon et al, 2000b ; Sindic et al, 2001 ; de Sousa et al, 2014 ; Mo et al, 2016 ).…”

Section: Central Neurological System Complicationsmentioning

confidence: 99%

“…Neurological complications recorded in pediatrics include ADEM (Kamath and Ranjit, 2006 ), hepatic encephalopathy (Kamath and Ranjit, 2006 ), acute childhood myositis (Ahmad et al, 2007 ), hemiconvulsion-hemiplegia-epilepsy (Gastaut et al, 1960 ; Saini et al, 2017 ), parkinsonism (Fong et al, 2014 ), ischemic stroke due to dengue vasculitis (Nanda et al, 2014 ), sub-arachnoid hemorrhage (Kamath and Ranjit, 2006 ), and transverse myelitis (Fong et al, 2016 ). Most cases achieve satisfactory recovery after timely treatment (Kankirawatana et al, 2000 ; Cam et al, 2001 ; Kamath and Ranjit, 2006 ).…”

Section: Neurological Complications In Childrenmentioning

confidence: 99%

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Neurological Manifestations of Dengue Infection

Zhang

Liu

et al. 2017

Front. Cell. Infect. Microbiol.

156

146

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Dengue counts among the most commonly encountered arboviral diseases, representing the fastest spreading tropical illness in the world. It is prevalent in 128 countries, and each year >2.5 billion people are at risk of dengue virus infection worldwide. Neurological signs of dengue infection are increasingly reported. In this review, the main neurological complications of dengue virus infection, such as central nervous system (CNS), peripheral nervous system, and ophthalmic complications were discussed according to clinical features, treatment and possible pathogenesis. In addition, neurological complications in children were assessed due to their atypical clinical features. Finally, dengue infection and Japanese encephalitis were compared for pathogenesis and main clinical manifestations.

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Section: Central Neurological System Complicationsmentioning

confidence: 99%

Section: Central Neurological System Complicationsmentioning

confidence: 99%

Section: Central Neurological System Complicationsmentioning

confidence: 99%

Section: Neurological Complications In Childrenmentioning

confidence: 99%

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Neurological Manifestations of Dengue Infection

Zhang

Liu

et al. 2017

Front. Cell. Infect. Microbiol.

156

146

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“…A further 136 were excluded on the basis of title and abstract and 19 studies did not meet the eligibility criteria on full text screening ( Figure 1). The remaining 25 studies were eligible and full text was assessed for inclusion in the final review [7,9,10,[12][13][14][15][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. Most of the studies were from Asia (76%; 19/25) and the rest from South America (24%; 6/25).…”

Section: Resultsmentioning

confidence: 99%

Risk of Transverse Myelitis Following Dengue Infection: A Systematic Review of the Literature

Badat¹,

Oligbu²

2018

Preprint

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Introduction: Dengue virus (DENV) is one of the most common arbovirus diseases, with a wide spectrum of presentation. Spinal cord involvement in dengue infection (DF) is rare. However, the risk of transverse myelitis (TM) following Dengue has not been systematically assessed. Methods: We undertook a systematic review of published English literature from January 1974 to December 2017 to assess risk of TM and outcomes following DF. Data sources included EMBASE, MEDLINE, Cochrane library, ISI web of knowledge, conference proceedings and references within identified articles. Results: We identified 242 potential studies, 62 were duplicates. A further 136 were excluded on the basis of title and abstract and 19 studies did not meet the eligibility criteria on full text screening. We included 25 publications involving 2672 cases of DF. A small proportion (10.8%, (289/2672)) had neurological complications, of which 2.3% (61/2672) was TM. For articles reporting epidemiological data, the neurological complication was twice in males compared to female 67.7% (130/192) vs. 32.7% (62/192) and 1.5-fold increase TM for males 59.3% (32/54) vs 40.7% (22/54). The mean age at presentation was 33.1years (range 0.75-61), with onset at 11.7days. The method of diagnosing TM due to DF was mainly IgM seropositivity 92% (n = 23/25) and the commonest treatment modality was steroid 78.3% (n = 18/23). Only half had full recovery 50.8% (n = 31/61). There was no mortality following dengue, however, the crude case fatality rate following TM was 3.3% (n = 2/61). Conclusion: This review highlights the risk of TM following dengue. Although neurological complications are rare, especially TM, once set in, it is associated with a significant morbidity.

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