Longitudinal Exposomics in a Multiomic Wellness Cohort Reveals Distinctive and Dynamic Environmental Chemical Mixtures in Blood
Kalliroi Sdougkou,
Stefano Papazian,
Bénilde Bonnefille
et al.
Abstract:Chemical exposomes
can now be comprehensively measured
in human
blood, but knowledge of their variability and longitudinal stability
is required for robust application in cohort studies. Here, we applied
high-resolution chemical exposomics to plasma of 46 adults, each sampled
6 times over 2 years in a multiomic cohort, resulting in 276 individual
exposomes. In addition to quantitative analysis of 83 priority target
analytes, we discovered and semiquantified substances that have rarely
or never been reported in… Show more
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