Longitudinal evaluation of criteria for subjective cognitive decline and preclinical Alzheimer's disease in a memory clinic sample

Eckerström, Marie; Göthlin, Mattias; Rolstad, Sindre; Hessen, Erik; Eckerström, Carl; Nordlund, Arto; Johansson, Boo; Svensson, Johan; Jonsson, Michael; Sacuiu, Simona; Wallin, Anders

doi:10.1016/j.dadm.2017.04.006

Cited by 35 publications

(36 citation statements)

References 54 publications

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“…SCD was assessed using the Memory failures in everyday life following severe head injury [28] and the Subjective Cognitive Decline Questionnaire (SCD-Q) [29]. Although SCD has been recently included in the preclinical stage of AD [30, 31], its identification in the healthy aging population is essential [32] due to their association with a higher risk of AD [33, 34]. …”

Section: Methodsmentioning

confidence: 99%

APOE ε4 Genotype and Cognitive Reserve Effects on the Cognitive Functioning of Healthy Elders

López

Turrero

Delgado

et al. 2017

Dement Geriatr Cogn Disord

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Aim: To test the association between cognitive performance and APOE genotype, and to assess potential modifications of this association by sociodemographic and neuroanatomical factors in a sample of 74 healthy elders. Methods: Firstly, we explored the isolated role of the APOE ɛ4 genotype (i.e., APOE4) in different neuropsychological tests, and then the effects of its interaction with sociodemographic (i.e., age, gender, and educational level) and neuroanatomical (i.e., hippocampal volumes) variables. Subsequently, we performed the same analyses after dividing the sample into two subgroups according to their Mini-Mental State Examination scores (control-high group ≥29 and control-low group < 29). Results: In the whole group, APOE4 carriers exhibited a significantly poorer execution in several cognitive domains including global cognitive functioning, episodic memory, verbal fluency, and naming. This effect was more noticeable in older and less educated subjects. The separated analyses revealed that APOE4 carriers in the control-low group exhibited lower scores in global cognitive functioning and episodic memory, while no effects were observed in the control-high group. Neither gender nor hippocampal volumes showed a significant interaction effect with APOE genotype. Conclusions: Current results point out that APOE4 genotype influences healthy aged cognition, although factors such age or educational attainment seem to modulate its effects.

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Section: Methodsmentioning

confidence: 99%

APOE ε4 Genotype and Cognitive Reserve Effects on the Cognitive Functioning of Healthy Elders

López

Turrero

Delgado

et al. 2017

Dement Geriatr Cogn Disord

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“…Persons with SCD complain about their memory but present scores within the normal range on standardized neuropsychological tests. It has been shown that a significant proportion of those individuals will later develop MCI and AD dementia, particularly if they display biomarker evidence of AD ( Eckerström et al, 2017 ) or express worry about this perceived change in cognitive ability in addition to their memory complaints ( Jessen, Amariglio, et al, 2014 ; Reisberg, Shulman, Torossian, Leng, & Zhu, 2010 ). Hence, SCD might be considered as an interesting construct to study the first clinico-pathological manifestations of AD ( Dubois et al, 2016 ; Sperling et al, 2011 ).…”

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confidence: 99%

Evidence of a Relation Between Hippocampal Volume, White Matter Hyperintensities, and Cognition in Subjective Cognitive Decline and Mild Cognitive Impairment

Caillaud

Hudon

Boller

et al. 2019

The Journals of Gerontology: Series B

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Objective The concepts of mild cognitive impairment (MCI) and subjective cognitive decline (SCD) have been proposed to identify individuals in the early stages of Alzheimer’s disease (AD), or other neurodegenerative diseases. One approach to validate these concepts is to investigate the relationship between pathological brain markers and cognition in those individuals. Method We included 126 participants from the Consortium for the Early Identification of Alzheimer’s disease-Quebec (CIMA-Q) cohort (67 SCD, 29 MCI, and 30 cognitively healthy controls [CH]). All participants underwent a complete cognitive assessment and structural magnetic resonance imaging. Group comparisons were done using cognitive data, and then correlated with hippocampal volumes and white matter hyperintensities (WMHs). Results Significant differences were found between participants with MCI and CH on episodic and executive tasks, but no differences were found when comparing SCD and CH. Scores on episodic memory tests correlated with hippocampal volumes in both MCI and SCD, whereas performance on executive tests correlated with WMH in all of our groups. Discussion As expected, the SCD group was shown to be cognitively healthy on tasks where MCI participants showed impairment. However, SCD’s hippocampal volume related to episodic memory performances, and WMH to executive functions. Thus, SCD represents a valid research concept and should be used, alongside MCI, to better understand the preclinical/prodromal phase of AD.

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“…Eckerström et al . followed up 122 SCD subjects for a mean time of 48 months and found a very poor accuracy of SCD‐plus criteria as predictors of AD. More recently, a cross‐sectional description of participant characteristics in an ongoing prospective cohort study on SCD showed that age ≥60 and ApoE ε4 were associated with positivity of cerebrospinal fluid biomarkers.…”

Section: Discussionmentioning

confidence: 99%

“…According to the authors, SCD‐plus represents an open set of criteria reflecting current knowledge, which allows for addition and subtraction of items as research progresses. Only one longitudinal study which assessed SCD‐plus criteria in predicting the risk of conversion to AD is known which found a very poor accuracy of SCD‐plus criteria. However, that study considered only a 24‐month follow‐up time.…”

Section: Introductionmentioning

confidence: 99%

Assessing the effectiveness of subjective cognitive decline plus criteria in predicting the progression to Alzheimer’s disease: an 11‐year follow‐up study

Mazzeo

Padiglioni

Bagnoli

et al. 2020

Euro J of Neurology

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Background and purpose: Subjective cognitive decline (SCD) is a self-experienced decline in cognitive capacity with normal performance on standardized cognitive tests and has been shown to increase the risk of Alzheimer's disease (AD). SCD could also be related to other conditions such as normal aging, psychiatric, neurological or medical disorders. The SCD Initiative proposed a set of features (SCD-plus) that increase the likelihood of preclinical AD in individuals with SCD. Our aim was to assess the effect of these features on the risk of conversion from SCD to AD. Methods: In total 150 SCD subjects who underwent extensive neuropsychological investigation, assessment of cognitive complaints and apolipoprotein E (ApoE) genotyping at baseline and clinical-neuropsychological follow-up for a mean time of 11 years were included. Results: During the follow-up, 20 subjects developed AD. Considering SCDplus features, age at onset ≥60 years and ApoE e4 significantly increased the risk of conversion from SCD to AD. When our sample was stratified into three groups (no risk factor, one risk factor, two risk factors), the proportion of conversion was statistically significantly different between the three groups. Conclusions: Our model allows the risk of AD to be stratified in patients experiencing SCD according to age at onset and ApoE genotype.

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Longitudinal evaluation of criteria for subjective cognitive decline and preclinical Alzheimer's disease in a memory clinic sample

Cited by 35 publications

References 54 publications

<b><i>APOE</i></b> ε4 Genotype and Cognitive Reserve Effects on the Cognitive Functioning of Healthy Elders

<b><i>APOE</i></b> ε4 Genotype and Cognitive Reserve Effects on the Cognitive Functioning of Healthy Elders

Evidence of a Relation Between Hippocampal Volume, White Matter Hyperintensities, and Cognition in Subjective Cognitive Decline and Mild Cognitive Impairment

Assessing the effectiveness of subjective cognitive decline plus criteria in predicting the progression to Alzheimer’s disease: an 11‐year follow‐up study

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