Longitudinal evaluation of a household energy package on blood pressure, central hemodynamics, and arterial stiffness in China

Clark, Sierra; Schmidt, Alexandra M.; Carter, Ellison M.; Schauer, James J.; Yang, Xudong; Ezzati, Majid; Daskalopoulou, Stella S.; Baumgartner, Jill

doi:10.1016/j.envres.2019.108592

Cited by 19 publications

(21 citation statements)

References 38 publications

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“…These factors include potential effect modifiers such as genetic pre-disposition and exercise or dietary factors that can affect some of the measured cardiometabolic markers. These are limitations that have been reported in other similar studies [29,35].…”

Section: Discussionmentioning

confidence: 62%

“…In high-income countries such as Australia, gas and electric cooking appliances along with heating and cooling appliances, furniture, dust re-suspension and indoor combustion of solid fuels (e.g., wood and coal) are significant contributors to indoor air pollution [31,33,34]. In contrast, major sources of indoor air pollution in low- and middle-income countries traditionally involve cooking and heating using solid fuels such as crop residues, dung, or wood in poorly ventilated homes [22,25,29,35,36].…”

Section: Introductionmentioning

confidence: 99%

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Associations Between Sub-Clinical Markers of Cardiometabolic Risk and Exposure to Residential Indoor Air Pollutants in Healthy Adults in Perth, Western Australia: A Study Protocol

Gilbey

Reid

Huxley

et al. 2019

IJERPH

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Background: A growing body of epidemiological and clinical evidence has implicated air pollution as an emerging risk factor for cardiometabolic disease. Whilst individuals spend up to two-thirds of daily time in their domestic residential environment, very few studies have been designed to objectively measure the sub-clinical markers of cardiometabolic risk with exposure to domestic indoor air pollutants. This cross-sectional study aims to investigate associations between the components of domestic indoor air quality and selected sub-clinical cardiometabolic risk factors in a cohort of healthy adults living in Perth, Western Australia. Methods: One hundred and eleven non-smoking adults (65% female) living in non-smoking households who were aged between 35–69 years were recruited for the project. Study subjects were invited to participate in all sections of the study, which included: Domestic indoor air monitoring along with the concurrent 24 h ambulatory monitoring of peripheral and central blood pressure and measures of central hemodynamic indices, standardized questionnaires on aspects relating to current health status and the domestic environment, a 24 h time-activity diary during the monitoring period, and clinic-based health assessment involving collection of blood and urine biomarkers for lipid and glucose profiles, as well as measures of renal function and an analysis of central pulse wave and pulse wave velocity. Results: This study provides a standardized approach to the study of sub-clinical cardiometabolic health effects that are related to the exposure to indoor air pollution. Conclusion: The findings of this study may provide direction for future research that will further contribute to our understanding of the relationship that exists between indoor air pollution and sub-clinical markers of cardiometabolic risk.

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Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Associations Between Sub-Clinical Markers of Cardiometabolic Risk and Exposure to Residential Indoor Air Pollutants in Healthy Adults in Perth, Western Australia: A Study Protocol

Gilbey

Reid

Huxley

et al. 2019

IJERPH

View full text Add to dashboard Cite

show abstract

“…The proportion of participants who had a diagnosed heart condition in this study was 10%. Clark et al (2019) also saw a significant reduction in brachial SBP, which again could be partly explained by the participants’ mean age of 51 years as well as mean a BMI of 24 kg/m 2 , combined with the fact that 60% of participants had exposure to second hand smoke. Similar to Alexander et al 2014, only 14% of the participants were on hypertensive medication, which is unlikely to have affected the outcome significantly.…”

Section: Discussionmentioning

confidence: 90%

“…In addition, Clark et al (2013) also reported a significant reduction in CO post-intervention amounting to –18.60 ppm. Clark et al (2019) was the only study that did not investigate the impact of the ICS intervention on air-quality. Overall, it appears that the accompanying reductions in PM 2.5 and CO in these three studies corroborate reduction in SBP.…”

Section: Discussionmentioning

confidence: 99%

Do improved biomass cookstove interventions improve indoor air quality and blood pressure? A systematic review and meta-analysis

Kumar

Phillip

Cooper

et al. 2021

Preprint

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BackgroundHousehold air pollution (HAP) kills 4 million annually, with access to clean cooking being a challenge for 37% of the world’s population. Whilst there have been advancements in improved biomass cookstove (ICS) technologies, reviews on the impact of these ICS on HAP are now more than three years old.ObjectivesThis review and meta-analysis examines the most recent evidence on the impact of ICS on HAP and blood pressure (BP).MethodsA literature search was conducted using scientific literature databases and grey literature. Studies were included if they were published between January 2012 and June 2020, reported impact of ICS interventions in non-pregnant adults in low/middle-income countries, and reported post-intervention results along with baseline of traditional cookstoves. Outcomes included 24- or 48-hour averages of kitchen area fine particulate matter (PM2.5), carbon monoxide (CO), mean systolic BP (SBP) and mean diastolic BP (DBP). Meta-analyses estimated weighted mean differences between baseline and post-intervention values for all outcome measures.ResultsNine studies were included; eight contributed estimates for HAP and three for BP. Interventions lead to significant reductions in PM2.5 (−0.28 mg/m3, 95% CI: -0.46, -0.10), CO (−6.59ppm, 95%CI: - 10.73, -2.46) and SBP (−2.82mmHg, 95% CI: -5.53, -0.11); and a non-significant reduction in DBP (−0.80 mmHg, 95%CI: -2.33, 0.73), when compared to baseline of traditional cookstoves. Except for DBP, greatest reductions in all outcomes came from standard combustion ICS with a chimney, compared to ICS without a chimney and advanced combustion ICS. WHO air quality targets were met by post-intervention values for CO but not for PM2.5.ConclusionOur review suggests that ICS with a chimney results in the greatest reductions in HAP and BP. Further research on qualitative impact of such ICS on end-users is required to understand feasibility of adoption at scale.

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“…A full description of the study design and study population is published elsewhere [27,28]. Briefly, in 2014, we enrolled 205 Chinese women ages 28-88 years old into a longitudinal study of energy use, air pollution, and health.…”

Section: Study Design and Populationmentioning

confidence: 99%

A feasibility study of metabolic phenotyping of dried blood spot specimens in rural Chinese women exposed to household air pollution

Loo

Carter

et al. 2020

J Expo Sci Environ Epidemiol

Self Cite

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Background Exposure-response studies and policy evaluations of household air pollution (HAP) are limited by current methods of exposure assessment which are expensive and burdensome to participants. Methods We collected 152 dried blood spot (DBS) specimens during the heating and non-heating seasons from 53 women who regularly used biomass-burning stoves for cooking and heating. Participants were enrolled in a longitudinal study in China. Untargeted metabolic phenotyping of DBS were generated using ultra-high performance liquid chromatography coupled with mass spectrometry to exemplify measurement precision and assessment for feasibility to detect exposure to HAP, evaluated by season (high pollution vs. low pollution) and measured personal exposure to fine particulate matter <2.5 μm diameters (PM 2.5) and black carbon (BC) in the 48-h prior to collecting the DBS specimen. Results Metabolites e.g., amino acids, acyl-carnitines, lyso-phosphorylcholines, sphinganine, and choline were detected in the DBS specimens. Our approach is capable of detecting the differences in personal exposure to HAP whilst showing high analytical reproducibility, coefficient of variance (CV) <15%, meeting the U.S. Food and Drug Administration criteria. Conclusions Our results provide a proof of principle that high-resolution metabolic phenotypic data can be generated using a simple DBS extraction method thus suitable for exposure studies in remote, low-resource settings where the collection of serum and plasma is logistically challenging or infeasible. The analytical run time (19 min/specimen) is similar to most global phenotyping methods and therefore suitable for large-scale application. Keywords Dried blood spot • Exposome • Metabonomics/metabolomics/metabolic phenotyping • Molecular epidemiological study • Biomass-related air pollution • PM 2.5

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Longitudinal evaluation of a household energy package on blood pressure, central hemodynamics, and arterial stiffness in China

Cited by 19 publications

References 38 publications

Associations Between Sub-Clinical Markers of Cardiometabolic Risk and Exposure to Residential Indoor Air Pollutants in Healthy Adults in Perth, Western Australia: A Study Protocol

Associations Between Sub-Clinical Markers of Cardiometabolic Risk and Exposure to Residential Indoor Air Pollutants in Healthy Adults in Perth, Western Australia: A Study Protocol

Do improved biomass cookstove interventions improve indoor air quality and blood pressure? A systematic review and meta-analysis

A feasibility study of metabolic phenotyping of dried blood spot specimens in rural Chinese women exposed to household air pollution

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