Longitudinal estimation of intramuscular Tibialis Anterior coherence during subacute spinal cord injury: relationship with neurophysiological, functional and clinical outcome measures

Abstract

BackgroundEstimation of surface intramuscular coherence has been used to indirectly assess pyramidal tract activity following spinal cord injury (SCI), especially within the 15-30 Hz bandwidth. However, change in higher frequency (>40 Hz) muscle coherence during SCI has not been characterised. Thus, the objective of this study was to identify change of high and low frequency intramuscular Tibialis Anterior (TA) coherence during incomplete subacute SCI.MethodsFifteen healthy subjects and 22 subjects with motor incomplete SCI (American Spinal Injury Association Impairment Scale, AIS, C or D grade) were recruited and tested during 4 sessions performed at 2-week intervals up to 8 months after SCI. Intramuscular TA coherence estimation was calculated within the 10–60 Hz bandwidth during controlled maximal isometric and isokinetic foot dorsiflexion. Maximal voluntary dorsiflexion torque, gait function measured with the WISCI II scale, and TA motor evoked potentials (MEP) were recorded.ResultsDuring subacute SCI, significant improvement in total lower limb manual muscle score, TA muscle strength and gait function were observed. No change in TA MEP amplitude was identified. Significant increase in TA coherence was detected in the 40–60 Hz, but not the 15–30 Hz bandwidth. The spasticity syndrome was associated with lower 15-30 Hz TA coherence during maximal isometric dorsiflexion and higher 10–60 Hz coherence during fast isokinetic movement (p < 0.05).ConclusionsLongitudinal estimation of neurophysiological and clinical measures during subacute SCI suggest that estimation of TA muscle coherence during controlled movement provides indirect information regarding adaptive and maladaptive motor control mechanisms during neurorehabilitation.

Spasms after spinal cord injury show low-frequency intermuscular coherence

“…We have used intermuscular coherence, which conveniently measures shared input to muscle pairs. By contrast, Bravo-Esteban et al (2014 , 2017 ) measured intramuscular coherence using paired recordings from the TA muscle. In spinal cord-injured subjects with incomplete lesions (ASIA C or D), they found significant coherence at lower frequencies (10–16 Hz) during brief voluntary contractions.…”

“…The variable function of such circuits may explain why ~10 Hz cortico-muscular coherence can occasionally be seen ( Raethjen et al 2002 ; Williams et al 2009 ). In incomplete spinal cord injury, Bravo-Esteban et al (2014 , 2017 ) demonstrated that cortico-muscular coherence around 10–16 Hz correlated with the degree of spasticity. It remains to be determined which subcortical neural structure generates low-frequency rhythmic activity.…”

Fosl1 Targets AMPK to Inhibit Autophagy-Mediated Anti-Apoptotic and Anti-Inflammatory Effects in Spinal Cord Injury

“…A: Schematic of the experimental strategy used to screen the potential differential genes in the GEO database. B: The heatmaps generated by R language using the mRNA expression data of the SCI group and the sham group in GEO at 1 d, 3 Inhibition of autophagy neutralized the bene ts on the autophagic activity and cell viability after AMPK activation in the injured PC-12 cells with si-Fosl1 treatment but promoted in ammation and cell apoptosis. A: Cell viability was detected using CCK-8 kits in the control group and the CQ group.…”

“…Spinal cord injury (SCI) is a disastrous nerve trauma in the central nervous system (CNS) currently without su cient treatment options, which affects several millions people worldwide and leads to catastrophic complications [1,2], such as neurological de cits [3], paraplegia [4], osteoporosis [5], and others. These complications place huge psychological and physical burdens on patients and threaten their health and life quality [6].…”

Ketogenic Diet-mediated Steroid Metabolism Reprogramming Improves the Immune Microenvironment and Myelin Growth of Spinal Cord Injury Rats Through Gene Analysis and Co-expression Network Analysis

“…Spinal cord injury (SCI) is a devastating event that can lead to neurological de cits and motor dysfunction [1][2]. The dysfunction of motor and sensory functions after SCI is caused by the following two processes: primary injury and secondary injury.…”