Longitudinal Epidemiology of Viral Infectious Diseases Combining Virus Isolation, Antigenic Analysis, and Phylogenetic Analysis as Well as Seroepidemiology in Yamagata, Japan, between 1999 and 2018

Mizuta, Katsumi; Tanaka, Waka; Komabayashi, Kenichi; Tanaka, Shizuka; Seto, Junji; Aoki, Yoko; Ikeda, Tatsuya

doi:10.7883/yoken.jjid.2018.500

Cited by 11 publications

(16 citation statements)

References 91 publications

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“…Real‐time PCR targeting nucleocapsid gene‐specific to HCoV‐OC43 was performed for specimens collected during 2014 to 2017, as reported from earlier studies 5,11 . Nasopharyngeal specimens were tested using the microplate method to isolate influenza virus, parainfluenza virus, respiratory syncytial virus, human metapneumovirus, adenovirus, enterovirus, rhinovirus, cytomegalovirus, and parechovirus 19‐22 …”

Section: Methodsmentioning

confidence: 99%

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Longitudinal epidemiology of human coronavirus OC43 in Yamagata, Japan, 2010–2017: Two groups based on spike gene appear one after another

Komabayashi

Matoba

Tanaka

et al. 2020

Journal of Medical Virology

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Human coronavirus OC43 (HCoV-OC43) is divided into genotypes A to H based on genetic recombination including the spike (S) gene. To investigate the longitudinal transition of the phylogenetic feature of the HCoV-OC43 S gene in a community, phylogenetic analysis of the S1 region of the S gene was conducted using 208 strains detected in Yamagata during 2010 to 2017 with reference strains of the genotype. The S1 sequences were divisible into four groups: A to D. All Yamagata strains belonged to either group B or group D. In group B, 46 (90.2%) out of 51 Yamagata strains were clustered with those of genotype E reference strains (cluster E). In group D, 28 (17.8%) and 122 (77.7%) out of 157 Yamagata strains were clustered, respectively, with genotype F and genotype G reference strains. In cluster G, 28 strains formed a distinct cluster. Monthly distributions of HCoV-OC43 in Yamagata in 2010 to 2017 revealed that group B and group D appeared one after another. In group B, the cluster E strains were prevalent recurrently. In conclusion, epidemics of HCoV-OC43 in Yamagata, Japan might be attributable to two genetically different groups: group B showed a recurrent epidemic of strains belonging to a single phylogenetic cluster and group D showed epidemic strains belonging to multiple clusters.

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Section: Methodsmentioning

confidence: 99%

“…5,11 Nasopharyngeal specimens were tested using the microplate method to isolate influenza virus, parainfluenza virus, respiratory syncytial virus, human metapneumovirus, adenovirus, enterovirus, rhinovirus, cytomegalovirus, and parechovirus. [19][20][21][22]…”

Section: Screening Of Hcovs and Coinfected Virusesmentioning

confidence: 99%

Longitudinal epidemiology of human coronavirus OC43 in Yamagata, Japan, 2010–2017: Two groups based on spike gene appear one after another

Komabayashi

Matoba

Tanaka

et al. 2020

Journal of Medical Virology

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“…We have been engaged in an epidemiological study of viral acute respiratory infections at paediatric clinics working in collaboration with the Yamagata Prefectural Health Authorities as part of the National Epidemiological Surveillance of Infectious Diseases (NESID) in Japan [23]. We isolated PeVA1, PeVA3 and PeVA6 strains using a routine microplate method including six cell lines as well as the LLC-MK2-N cell line, which is sensitive to PeVA viruses, in combination with molecular screening for the PeVA genome, and performed a seroepidemiological study using these representative Yamagata PeVA1, PeVA3 and PeVA6 isolates in 2014 [15,17,23]. In 2016, we succeeded in isolating the first PeVA4 strain in Yamagata [24].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of parechovirus A1, A3 and A4 antibodies in Yamagata, Japan, between 1976 and 2017

Mizuta

Komabayashi

Aoki

et al. 2020

Journal of Medical Microbiology

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Introduction. Although new parechovirus A (PeVA) types, including parechovirus A3 (PeVA3) and PeVA4, have been reported in this century, there have not yet been any seroepidemiological studies on PeVA over a period of several decades. Hypothesis/Gap Statement. The authors hypothesize that PeVA3 and PeVA4 emerged recently. Aims. The aim was to clarify changes in the seroprevalence of PeVA1, PeVA3 and PeVA4. Methodology. Neutralizing antibodies (NT Abs) were measured among residents in Yamagata, Japan in 1976, 1983, 1985, 1990, 1999 and 2017. Results. The total NT Ab-positive rate for PeVA1 was between 90.7 and 100 % for all years analysed, with that for PeVA3 increasing from 39.6 % in 1976 to 69.6 % in 2017, and that for PeVA4 decreasing from 93.9 % in 1976 to 49.1 % in 2017. The distribution of NT Ab titres for PeVA1, PeVA3 and PeVA4 among those aged less than 20 years old was as follows: those ≥1 : 32 for PeVA1 were between 68.0–89.2 % for all years analysed; those ≥1 : 32 for PeVA3 was 15.4 % in 1976, 44.3–54.9 % in 1983–1990 and 64.8–68.0 % in 1999–2017; and those ≥1 : 32 for PeVA4 were between 49.1–67.2 % in 1976–1990, 41.3 % in 1999 and 23.8 % in 2017. Conclusions. Our findings in this seroepidemiological study over four decades suggested that PeVA1 has been stably endemic, while PeVA3 appeared around 1970s and has spread since then as an emerging disease, and occasional PeVA4 infections were common in 1970s and 1980s but have been decreasing for several decades in our community.

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“…With respect to the viruses that were not included in the ResPlex II kit, we could not perform tests such as PCR for their detection, due to limited clinical specimens. It was reported that adherent MDCK cells (MDCK‐A) showed no growth of mumps viruses, measles viruses, rubella viruses, herpes simplex viruses, cytomegaloviruses, and parechoviruses; hence, there seems to be little or no risk of amplification of these viruses during passages in MDCK‐S or MDCK‐A.…”

Section: Discussionmentioning

confidence: 99%

Comparison of suspension MDCK cells, adherent MDCK cells, and LLC‐MK2 cells for selective isolation of influenza viruses to be used as vaccine seeds

Harada

Takahashi

Trusheim

et al. 2019

Influenza Resp Viruses

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Background: Cell-based influenza vaccines can solve the problem of the frequent occurrence of egg adaptation-associated antigenic changes observed in egg-based vaccines. Seed viruses for cell-based vaccines can be prepared from clinical specimens by cell culture; however, clinical samples risk harboring respiratory viruses other than influenza virus. Therefore, it is necessary to investigate the patterns of co-infection in clinical samples and explore whether cell culture technology can selectively propa-

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Longitudinal Epidemiology of Viral Infectious Diseases Combining Virus Isolation, Antigenic Analysis, and Phylogenetic Analysis as Well as Seroepidemiology in Yamagata, Japan, between 1999 and 2018

Cited by 11 publications

References 91 publications

Longitudinal epidemiology of human coronavirus OC43 in Yamagata, Japan, 2010–2017: Two groups based on spike gene appear one after another

Longitudinal epidemiology of human coronavirus OC43 in Yamagata, Japan, 2010–2017: Two groups based on spike gene appear one after another

Seroprevalence of parechovirus A1, A3 and A4 antibodies in Yamagata, Japan, between 1976 and 2017

Comparison of suspension MDCK cells, adherent MDCK cells, and LLC‐MK2 cells for selective isolation of influenza viruses to be used as vaccine seeds

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