2001
DOI: 10.1210/jc.86.2.724
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Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men

Abstract: Many studies have shown cross-sectional (and two small studies, longitudinal) declines in total and/or free testosterone (T) levels, with age, in men. The extent to which decline in T is the result of the aging process per se, as opposed to chronic illness, medication use, and other age-related factors, remains controversial. The frequency with which aging leads to T levels consistent with hypogonadism has also not been defined. These issues bear on the potential use of T replacement in aging men, because agin… Show more

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Cited by 1,013 publications
(927 citation statements)
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“…As discussed previously, Harman et al 6 proposed that ageassociated changes in potentially modifiable lifestyle factors could contribute to the decline in serum testosterone levels in men. The scarcity of longitudinal data on changes in hormones, BMI and age in a well-characterized sample of adult men has not allowed for a detailed analysis of this hypothesis.…”
Section: Discussionmentioning
confidence: 94%
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“…As discussed previously, Harman et al 6 proposed that ageassociated changes in potentially modifiable lifestyle factors could contribute to the decline in serum testosterone levels in men. The scarcity of longitudinal data on changes in hormones, BMI and age in a well-characterized sample of adult men has not allowed for a detailed analysis of this hypothesis.…”
Section: Discussionmentioning
confidence: 94%
“…[1][2][3][4][5][6][7] Additionally, there is an age-related increase in sex hormone binding globulin (SHBG), which binds about 44% of testosterone with high affinity. The non-SHBG-bound fraction of testosterone, the bioavailable testosterone fraction, appears to decrease with age.…”
Section: Introductionmentioning
confidence: 99%
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“…Serum levels of total testosterone and free testosterone decrease in elderly men, and SHBG levels increase [9][10][11][12]. Furthermore, the numbers of major cells in the testis, such as Sertoli cells, Leydig cells, and germ cells, decrease with age [13][14][15][16][17][18].…”
Section: Discussionmentioning
confidence: 99%
“…About 20% of healthy men over age 60 have a total testosterone below the normal range determined in healthy young men (1). The high prevalence of lower testosterone in older men and aggressive marketing of new formulations for nonspecific symptoms have resulted in a marked increase in testosterone prescribing over the last decade (2)(3)(4).…”
Section: Introductionmentioning
confidence: 99%