Longitudinal effect of phthalates exposure on allergic diseases in children

Podlecka, Daniela; Gromadzińska, Jolanta; Mikołajewska, Karolina; Fijałkowska, Beata; Stelmach, Iwona; Jerzyńska, Joanna

doi:10.1016/j.anai.2020.03.022

Cited by 22 publications

(11 citation statements)

References 44 publications

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“…In 2017, Li et al [42] performed a systematic review and meta-analysis including 5 [43][44][45][46][47] of these 13 studies, and observed that prenatal exposure to MBzP was associated with an increased risk of asthma. Since this systematic review, a further 8 studies have been published [48][49][50][51][52][53][54][55]. In 2 cohorts, in utero exposure to long-chain phthalates and DiDP and DiNP metabolites was associated with an increased risk of bronchiolitis/bronchitis, wheezing, and asthma [49,53].…”

Section: Current Evidence From Birth Cohort Studiesmentioning

confidence: 99%

“…These findings are relevant, because DiDP and DiNP are increasingly used as DEHP substitutes and are the most commonly used plasticizers in Western Europe [56,57]. Recently, in another cohort, exposure to MBzP from pregnancy until 9 years of age was associated with an increased risk of wheezing and asthma in children; however, the study did not separately assess the effects of prenatal and postnatal exposures [54]. In contrast, a decreased risk of wheezing was associated with prenatal exposure to metabolites of DEP and DnBP [51].…”

Section: Current Evidence From Birth Cohort Studiesmentioning

confidence: 99%

“…Food allergies have been assessed in only 1 cohort, in which the authors observed that prenatal exposure to MBzP increased the risk of food allergy [55]. The same cohort also found an association between DEHP metabolites and increased risk of food allergies and lower risk of atopic dermatitis; however, no difference was made between prenatal and postnatal exposures in the models [54]. Finally, 2 studies explored the link between phthalates and immune biomarkers: one study found an association between a DnBP metabolite and higher T H 2 percentage in children younger than 5 years [52], whereas the other did not find any association with immune markers measured in cord blood [48].…”

Section: Current Evidence From Birth Cohort Studiesmentioning

confidence: 99%

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Prenatal Exposure to Endocrine-Disrupting Chemicals and Asthma and Allergic Diseases

Casas¹,

Gascón²

2020

J Investig Allergol Clin Immunol

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Endocrine-disrupting chemicals (EDCs) interfere with endogenous hormones and are present in many consumer products. In addition, they affect the development and functions of the immune system. The prenatal period is critical, because exposure to EDCs can induce irreversible changes in the immune system and increase susceptibility to asthma and allergies later in life. Nonpersistent EDCs are of most concern owing to their high annual production and potential toxicity. In this review, we summarize the literature on the effects of prenatal exposure to nonpersistent EDCs-phthalates and phenols-on asthma and allergic diseases, describe the underlying biological mechanisms, and make recommendations. Between 2011 and 2020, a total of 19 prospective studies were published. Most of these were focused on phthalates and bisphenol A and few on other bisphenols, parabens, triclosan, and benzophenone-3. Evidence remains insufficient owing to differences in chemical use between countries, sociodemographic characteristics of the study populations, misclassification of exposure due to the high within-subject variability, and heterogeneity in the definition of health outcomes. EDCs can alter airway cell differentiation and gut microbiota, shift the immune response towards T H 2, alter expression of T regulatory cells and T H 17, and weaken innate immunity. In order to better understand the burden of EDCs on the respiratory and immune systems, we require thoughtfully designed studies to assess exposure, appropriately characterize asthma and allergic phenotypes, and evaluate biological mechanisms and EDC mixtures. Research will help to implement public health policies that reduce exposure to EDCs in the community, particularly in pregnant women.

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Section: Current Evidence From Birth Cohort Studiesmentioning

confidence: 99%

Section: Current Evidence From Birth Cohort Studiesmentioning

confidence: 99%

Section: Current Evidence From Birth Cohort Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Prenatal Exposure to Endocrine-Disrupting Chemicals and Asthma and Allergic Diseases

Casas¹,

Gascón²

2020

J Investig Allergol Clin Immunol

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“…For example, the antibacterial agent triclosan has been positively associated with food and aeroallergen sensitization in male children in the NHANES cohort [222]; however, neither a Norwegian study nor a study from the USA observed an association between triclosan exposure and food allergen sensitization [223,224]. A few studies have examined the impact of phthalate exposure and have found that it is associated with an increased risk for food sensitization in children [225,226]. Given the increasing incidence of food allergies [227,228], this will be an important area of future study.…”

Section: Allergy and Obstructive Lung Diseasementioning

confidence: 99%

Metabolic Signatures of the Exposome—Quantifying the Impact of Exposure to Environmental Chemicals on Human Health

et al. 2020

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Human health and well-being are intricately linked to environmental quality. Environmental exposures can have lifelong consequences. In particular, exposures during the vulnerable fetal or early development period can affect structure, physiology and metabolism, causing potential adverse, often permanent, health effects at any point in life. External exposures, such as the “chemical exposome” (exposures to environmental chemicals), affect the host’s metabolism and immune system, which, in turn, mediate the risk of various diseases. Linking such exposures to adverse outcomes, via intermediate phenotypes such as the metabolome, is one of the central themes of exposome research. Much progress has been made in this line of research, including addressing some key challenges such as analytical coverage of the exposome and metabolome, as well as the integration of heterogeneous, multi-omics data. There is strong evidence that chemical exposures have a marked impact on the metabolome, associating with specific disease risks. Herein, we review recent progress in the field of exposome research as related to human health as well as selected metabolic and autoimmune diseases, with specific emphasis on the impacts of chemical exposures on the host metabolome.

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“…Some studies report that the exposure of these compounds to humans, especially pregnant women and fetuses, causes adverse health effects. However, they are prone to biodegradation, photodegradation and anaerobic degradation, which means that most of them do not persist for long in the environment (Chen et al 2017a, Karačonji et al 2017, Li et al 2019, Podlecka et al 2020. Therefore, in order to reduce sewage sludge contaminants and make its use feasible in agricultural systems, it is necessary to sanitize (clean) it through physical, chemical, and/or biological processes, which cause changes in the nutrients bioavailability, in pathogens reduction and odor.…”

Section: Introductionmentioning

confidence: 99%

Can fertilization with sewage sludge contaminate pineapple fruits with phthalates?

Sousa

Oliveira

Cardoso

et al. 2021

RSD

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O objetivo deste estudo foi avaliar os teores de ftalatos no solo e no fruto do abacaxizeiro adubado com diferentes tipos de lodos de esgotos e fertilizante mineral. O experimento foi conduzido em casa de vegetação, no delineamento em blocos casualizados, com sete tratamentos e três repetições. Os tratamentos foram: controle (C); adubação mineral (MF); adubação com lodo de esgoto solarizado (SS), lodo de esgoto caleado (CaS), lodo de esgoto seco em secadora (DS), lodo de esgoto compostado (CS) e lodo de esgoto vermicompostado (VS). Os teores de dimetil ftalato (DMP), dibutil ftalato (DBP) e dietil hexil ftalato (DEHP) no solo e na polpa de abacaxi foram analisados. As adubações com lodo de esgoto caleado (0,012 mg kg-1), secado em secadora (0,017 mg kg-1) e solarizado (0,031 mg kg-1) proporcionaram os menores teores de DMP no solo, enquanto o lodo de esgoto caleado (0,046 mg kg-1), secado em secadora (0,054 mg kg-1), solarizado (0,063 mg kg-1), e o vermicomposto (0,076 mg kg-1) proporcionaram os menores teores de DEHP na polpa de abacaxi. As adubações com lodos mantiveram os teores de DMP, DBP e DEHP nos solos, abaixo dos limites máximos para prevenção estabelecidos pela legislação ambiental brasileira. Além disso, os teores de todos os ftalatos na polpa de abacaxi ficaram abaixo dos limites críticos de segurança para o consumo desse alimento.

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Longitudinal effect of phthalates exposure on allergic diseases in children

Cited by 22 publications

References 44 publications

Prenatal Exposure to Endocrine-Disrupting Chemicals and Asthma and Allergic Diseases

Prenatal Exposure to Endocrine-Disrupting Chemicals and Asthma and Allergic Diseases

Metabolic Signatures of the Exposome—Quantifying the Impact of Exposure to Environmental Chemicals on Human Health

Can fertilization with sewage sludge contaminate pineapple fruits with phthalates?

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