Longitudinal effect of 20-year infancy-onset dietary intervention on food consumption and nutrient intake: the randomized controlled STRIP study

Matthews, Laurie A.; Rovio, Suvi; Jaakkola, Johanna; Niinikoski, Harri; Lagström, Hanna; Jula, Antti; Viikari, Jorma; Rönnemaa, Tapani; Simell, Olli; Raitakari, Olli T.; Pahkala, Katja

doi:10.1038/s41430-018-0350-4

Cited by 27 publications

(24 citation statements)

References 42 publications

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“…There were no statistically significant differences between the control and the intervention group (P=0.115) in the distribution of the temperament profiles; 26%, 57%, and 17% of the control children and 29%, 49%, and 23% of the intervention children belonged to the negative/low regulation, neutral/average regulation, and positive/high regulation groups, respectively. In line with our previous report 46 the intervention children had a healthier diet score at the age of 20 years than the control children (means=17.3 vs. 15.7, P=0.004).…”

Section: Resultssupporting

confidence: 91%

“…Following a multi-cohort study by Nettleton and others 45 and a study by Matthews and others in this same dataset, 46 we classified the foods into 11 food groups (Supplement table 2). The food groups were drawn from the evidence-based conclusions of the Nordic Nutrition Recommendations and the 2015-2020 Dietary Guidelines for Americans.…”

Section: Dietary Data and Diet Scorementioning

confidence: 99%

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Temperament profiles are associated with dietary behavior from childhood to adulthood

et al. 2020

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Section: Resultssupporting

confidence: 91%

Section: Dietary Data and Diet Scorementioning

confidence: 99%

Temperament profiles are associated with dietary behavior from childhood to adulthood

et al. 2020

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“…The STRIP intervention group visited the study center for individualized dietary counseling and nutrition education sessions at one-to three-month intervals until the child was two years old, and biannually thereafter until 20 years of age [10,22]. The main dietary goal was to reduce the intake of SAFAs and increase the unsaturated to saturated fat ratio.…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…Food consumption was recorded using a three-day food record at ages eight, 13, and 18 months, while a four-day food record was applied from ages two to 20 years (consecutive days; at least one weekend day included) [10,22]. Parents or other caregivers (i.e., nanny, etc.)…”

Section: Dietary Data and Dietary Target Scorementioning

confidence: 99%

Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention—Association with Metabolic Profile from Childhood to Adulthood

et al. 2021

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The Special Turku Coronary Risk Factor Intervention Project (STRIP) is a prospective infancy-onset randomized dietary intervention trial targeting dietary fat quality and cholesterol intake, and favoring consumption of vegetables, fruit, and whole-grains. Diet (food records) and circulating metabolites were studied at six time points between the ages of 9–19 years (n = 549–338). Dietary targets for this study were defined as (1) the ratio of saturated fat (SAFA) to monounsaturated and polyunsaturated fatty acids (MUFA + PUFA) < 1:2, (2) intake of SAFA < 10% of total energy intake, (3) fiber intake ≥ 80th age-specific percentile, and (4) sucrose intake ≤ 20th age-specific percentile. Metabolic biomarkers were quantified by high-throughput nuclear magnetic resonance metabolomics. Better adherence to the dietary targets, regardless of study group allocation, was assoiated with higher serum proportion of PUFAs, lower serum proportion of SAFAs, and a higher degree of unsaturation of fatty acids. Achieving ≥ 1 dietary target resulted in higher low-density lipoprotein (LDL) particle size, lower circulating LDL subclass lipid concentrations, and lower circulating lipid concentrations in medium and small high-density lipoprotein subclasses compared to meeting 0 targets. Attaining more dietary targets (≥2) was associated with a tendency to lower lipid concentrations of intermediate-density lipoprotein and very low-density lipoprotein subclasses. Thus, adherence to dietary targets is favorably associated with multiple circulating fatty acids and lipoprotein subclass lipid concentrations, indicative of better cardio-metabolic health.

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“…Several studies, such as the Special Turku Coronary Risk Factor Intervention Project (STRIP) and the Dietary Intervention Study in Children (DISC) showed that reducing fat intake (total fat, saturated fat and cholesterol) was not significantly associated with changes in somatic growth, pubertal development, mean body mass index, nutritional sufficiency and psychological/social features [ 32 , 33 ]. Moreover, a recent study concluded that beneficial nutritional interventions can be safely introduced in youth and sustained over 20 years [ 34 ].…”

Section: Management Of Dyslipidaemia In Childrenmentioning

confidence: 99%

Treatment of Dyslipidaemia in Children

Fiorentino

Chiarelli

2021

Biomedicines

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Childhood dyslipidaemia is one of the main traditional cardiovascular risk factors that initiate and exacerbate the atherosclerotic process. Healthcare providers may play a key role in the management of children with lipid abnormalities; however, they have to properly evaluate the normal lipid values and know the available treatment options in children and adolescents. Current guidelines recommend healthy behaviours as the first-line treatment for childhood dyslipidaemia. The therapeutic lifestyle changes should focus on dietary modifications, daily physical activity, reduction in body weight and tobacco smoking cessation. Parents play a key role in promoting their children’s healthy habits. In children with more severe forms of lipid abnormalities and in those who do not benefit from healthy behaviours, pharmacological therapy should be considered. Safe and effective medications are already available for children and adolescents. Statins represent the first-line pharmacological option, while ezetimibe and bile acid sequestrants are usually used as second-line drugs. Despite their limited use in children, other lipid-lowering agents (already approved for adults) are currently available or under study for certain categories of paediatric patients (e.g., familial hypercholesterolemia). Further studies are needed to evaluate the long-term efficacy, safety and tolerability of novel lipid-lowering drugs, especially in children.

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Longitudinal effect of 20-year infancy-onset dietary intervention on food consumption and nutrient intake: the randomized controlled STRIP study

Cited by 27 publications

References 42 publications

Temperament profiles are associated with dietary behavior from childhood to adulthood

Temperament profiles are associated with dietary behavior from childhood to adulthood

Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention—Association with Metabolic Profile from Childhood to Adulthood

Treatment of Dyslipidaemia in Children

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