Longitudinal distribution of vascular resistance in the pulmonary arteries, capillaries, and veins

Brody, Jerome S.; Stemmler, Edward J.; DuBois, Arthur B.

doi:10.1172/jci105773

Cited by 91 publications

(32 citation statements)

References 42 publications

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“…They were able to estimate the drop from pulmonary artery pressure to pulmonary capillary wedge pressure in relation to the flow of blood into the capillaries and found them remarkably in phase. The longitudinal pressure drop along the pulmonary blood vessels was measured by Brody, Stemmler, and DuBois (17). Using the pulmonary arterial and wedge pressure curve as measured by Lagerlof and Werk6 and shown in Fig.…”

Section: Discussionmentioning

confidence: 99%

Pulsatile uptake of CO in the human lung

Menkes¹,

Sera²,

Rogers³

et al. 1970

J. Clin. Invest.

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A B S T R A C T The instantaneous uptake of CO in the lungs was measured with a water-filled body plethysmograph in normal man. First, control measurements of plethysmograph pressure were made while the subject held his breath for 7 sec after breathing gas mixtures prepared to bring his alveolar Po2 and Pco2 close to mixed venous levels. Then, CO uptake measurements were made while he held his breath after inhaling the same gas mixtures with added CO (2.0%). The change in lung volume on CO minus the change in lung volume during the control measurement was a measure of the CO uptake in the lungs. Cardiopneumatic changes in lung gas volume were subtracted electrically. All of five subjects showed pulsatile CO uptake. The mean CO uptake was 103 ml/min. A peak uptake of 2.0 (range 1.6-2.3) times the mean uptake occurred 0.3-0.4 sec after the R wave of the EKG and a minimum uptake of 0.4 (range 0.2-0.5) times the mean uptake occurred during the tenth of a second before the R wave of the EKG. These results suggest that pulmonary capillary blood volume is pulsatile during the cardiac cycle.

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Section: Discussionmentioning

confidence: 99%

Pulsatile uptake of CO in the human lung

Menkes¹,

Sera²,

Rogers³

et al. 1970

J. Clin. Invest.

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“…The details of the methods used and the principles involved in this study are described in the preceding paper (1).…”

Section: Methodsmentioning

confidence: 99%

Differential reactivity in the pulmonary circulation

Brody¹,

Stemmler²

1968

J. Clin. Invest.

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“…The total vascular compliance (Ctol) and pulmonary vascular compliance (Cpul) were related to body weight, respectively, by Ctol ϭ 2.1 ϫ weight (90) and Cpul ϭ 0.408 ϫ weight (55). The distribution of vascular compliance along the pulmonary vascular system was set to be 0.08:0.65:0.27 for the artery, capillary, and venous beds (67) and that of resistance was set to be 0.46:0.34:0.20 (12). The parameters used in the cardiac model were derived from Refs.…”

Section: Parameter Assignmentmentioning

confidence: 99%

Hemodynamic performance of the Fontan circulation compared with a normal biventricular circulation: a computational model study

Liang

Senzaki

Kurishima

et al. 2014

American Journal of Physiology-Heart and Circulatory Physiology

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performance of the Fontan circulation compared with a normal biventricular circulation: a computational model study. Am J Physiol Heart Circ Physiol 307: H1056 -H1072, 2014. First published July 25, 2014 doi:10.1152/ajpheart.00245.2014The physiological limitations of the Fontan circulation have been extensively addressed in the literature. Many studies emphasized the importance of pulmonary vascular resistance in determining cardiac output (CO) but gave little attention to other cardiovascular properties that may play considerable roles as well. The present study was aimed to systemically investigate the effects of various cardiovascular properties on clinically relevant hemodynamic variables (e.g., CO and central venous pressure). To this aim, a computational modeling method was employed. The constructed models provided a useful tool for quantifying the hemodynamic effects of any cardiovascular property of interest by varying the corresponding model parameters in model-based simulations. Herein, the Fontan circulation was studied compared with a normal biventricular circulation so as to highlight the unique characteristics of the Fontan circulation. Based on a series of numerical experiments, it was found that 1) pulmonary vascular resistance, ventricular diastolic function, and systemic vascular compliance play a major role, while heart rate, ventricular contractility, and systemic vascular resistance play a secondary role in the regulation of CO in the Fontan circulation; 2) CO is nonlinearly related to any single cardiovascular property, with their relationship being simultaneously influenced by other cardiovascular properties; and 3) the stability of central venous pressure is significantly reduced in the Fontan circulation. The findings suggest that the hemodynamic performance of the Fontan circulation is codetermined by various cardiovascular properties and hence a full understanding of patientspecific cardiovascular conditions is necessary to optimize the treatment of Fontan patients.

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Longitudinal distribution of vascular resistance in the pulmonary arteries, capillaries, and veins

Cited by 91 publications

References 42 publications

Pulsatile uptake of CO in the human lung

Pulsatile uptake of CO in the human lung

Differential reactivity in the pulmonary circulation

Hemodynamic performance of the Fontan circulation compared with a normal biventricular circulation: a computational model study

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