Longitudinal Developmental Trajectories in Young Autistic Children Presenting with Seizures, Compared to those Presenting without Seizures, Gathered via Parent-report Using a Mobile Application

Forman, Phillip; Khokhlovich, Edward; Vyshedskiy, Andrey

doi:10.1007/s10882-022-09851-y

Cited by 13 publications

(9 citation statements)

References 27 publications

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“…Furthermore, the MSEC but none of the ATEC subscales demonstrated the benefit of the gluten-free diet and raw-vegetable-eating [ 30 ], as well as the detriment of high video and TV use [ 27 ]. Furthermore, the MSEC was more sensitive than the ATEC subscales to the negative effect of sleep problems [ 41 ] and seizures [ 42 ], as well as to the positive effects of early language intervention [ 28 ], joint engagement with an adult [ 43 ], pretend play [ 29 ], as well as meat-, egg-, and vegetable-eating [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Parent Reports, the Mental Synthesis Evaluation Checklist (MSEC) and the Autism Treatment Evaluation Checklist (ATEC), with the Childhood Autism Rating Scale (CARS)

Netson,

Schmiedel Fucks,

Schmiedel Sanches Santos

et al. 2024

Pediatric Reports

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This study compares two parent reports, the Mental Synthesis Evaluation Checklist (MSEC) and the Autism Treatment Evaluation Checklist (ATEC), with the Childhood Autism Rating Scale (CARS). The ATEC consists of four subscales, as follows: (1) expressive language, (2) sociability, (3) sensory awareness, and (4) health. The MSEC is complementary to the ATEC in measuring complex language comprehension. The parents of 143 autistic children, from 2 to 22 years of age (mean 6.7 ± 5.1 years), completed the MSEC and the ATEC questionnaires and a clinician assessed their CARS score. The CARS score correlated strongly with all parent reports, the complex language comprehension MSEC (r = 0.60, p < 0.0001), expressive language (r = 0.66, p < 0.0001), sociability (r = 0.58, p < 0.0001), sensory awareness (r = 0.71, p < 0.0001), and health (r = 0.53, p < 0.0001), as well as the total ATEC score (r = 0.75, p < 0.0001). The strongest correlation was between the CARS score and the composite of all five parent-reported scores (total ATEC + MSEC, r = 0.77, p < 0.0001). These results suggest a high fidelity of the MSEC and ATEC parent reports and especially of their composite score, total ATEC + MSEC.

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Section: Discussionmentioning

confidence: 99%

A Comparison of Parent Reports, the Mental Synthesis Evaluation Checklist (MSEC) and the Autism Treatment Evaluation Checklist (ATEC), with the Childhood Autism Rating Scale (CARS)

Netson,

Schmiedel Fucks,

Schmiedel Sanches Santos

et al. 2024

Pediatric Reports

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“…Caregivers provided informed consented to participate in the study and completed a 133-item questionnaire approximately every three months. Inclusion criteria for this study were as follows: absence of seizures (which commonly result in intermittent, unstable language deficits 24 ), absence of serious and moderate sleep problems (which are also associated with intermittent, unstable language deficits 25 ), age range of 4 to 21 years (the lower age cutoff was chosen to ensure that participants were exposed to complete set of items listed in Table 1 26 ; the upper age cutoff was chosen to avoid analysis of participants who may be linguistically declining due to aging). When caregivers have completed several evaluations, the last evaluation was used for analysis.…”

Section: Study Participantsmentioning

confidence: 99%

Four distinct stages of human language evolution are suggested by clustering of speech and language comprehension abilities in individuals with language deficits

Vyshedskiy,

Venkatesh,

Khokhlovich

2024

Preprint

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Use of syntactic language is a unique characteristic of humans. Following the split of human line from chimpanzee line around six million years ago some individuals acquired genetic modifications that enabled certain linguistic abilities. Over time these mutations were fixed in the human population and currently enable modern human syntactic communication. Inevitably, in some modern individuals, language-critical genes regress to their ancestral functionality causing partial loss of language abilities. Population studies of individuals with language deficits reveal language phenotypes that may correspond to stages of language evolution. Previously, we discovered three distinct language-comprehension-phenotypes: 1) individuals in the command-language-comprehension-phenotype were limited to comprehension of simple commands; 2) the modifier-language-comprehension-phenotype showed additional comprehension of color, size, and number modifiers; 3) the most-advanced syntactic-language-comprehension-phenotype added comprehension of complex grammatical sentences 1. In this study we clustered language comprehension skills together with speech abilities in 55,000 individuals-with-language-deficits. We discovered four distinct phenotypes: 1) command-language-comprehension with no-expressive-language; 2) modifier-language-comprehension with single-word-expressive-language; 3) modifier-language-comprehension with single-sentence-expressive-language; 4) syntactic-language-comprehension with multi-sentence-expressive-language. These phenotypes may align with four distinct stages of language comprehension and speech co-evolution. Using homology between neurological mechanisms underlying language and stone-tools-manufacturing we deduce the chronology of language acquisition in our ancestors.

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“…Caregivers consented to anonymized data analysis and completed an 133-item questionnaire approximately every three months. Inclusion criteria for this study were as follows: absence of seizures (that commonly result in intermittent, unstable language comprehension de cits 21 ), absence of serious and moderate sleep problems (that are also associated with intermittent, unstable language comprehension de cits 22 ), age range of 4 to 21 years (the lower age cutoff was chosen to ensure that participants were exposed to all variety of items listed in Table 1 13 ; the upper age cutoff was chosen to avoid analysis of participants who may be linguistically declining due to aging). When caregivers have completed several evaluations, the last evaluation was used for analysis.…”

Section: Study Participantsmentioning

confidence: 99%

Human language evolution: clustering of fifteen language comprehension abilities in 55558 individuals suggests three-step-wise language comprehension acquisition

Vyshedskiy

Venkatesh²,

Khokhlovich³

2023

Preprint

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There is an opposition between saltationist and gradualist hypotheses of human language comprehension evolution. The saltationist hypothesis argues for an abrupt step-like transition from non-recursive to recursive language sometime around 100,000 years ago. The gradualist scenario conjectures a much slower acquisition of grammatical and syntactic abilities over several million years. The former hypothesis expects a uniquely-human neurological mechanism made possible by a single mutation that resulted in simultaneous acquisition of a whole range of uniquely-human linguistic abilities, while the latter believes that many different mutations enabled various uniquely human neurological mechanisms that underlie human linguistic abilities. Studying co-acquisition of various linguistic abilities in modern humans can help resolve the two competing scenarios. The saltationist single-neurological-mechanism hypothesis predicts a two-cluster solution (one cluster of individuals who acquired that mechanism and another cluster of individuals who did not), while the gradualist scenario predicts the solution with many smaller clusters. Accordingly, we investigated co-acquisition of fifteen language comprehension abilities in 55,558 individuals using data-driven clustering analysis. Multiple clustering methods resulted in a robust three-cluster solution suggesting a three-step-wise language comprehension acquisition.

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Longitudinal Developmental Trajectories in Young Autistic Children Presenting with Seizures, Compared to those Presenting without Seizures, Gathered via Parent-report Using a Mobile Application

Cited by 13 publications

References 27 publications

A Comparison of Parent Reports, the Mental Synthesis Evaluation Checklist (MSEC) and the Autism Treatment Evaluation Checklist (ATEC), with the Childhood Autism Rating Scale (CARS)

A Comparison of Parent Reports, the Mental Synthesis Evaluation Checklist (MSEC) and the Autism Treatment Evaluation Checklist (ATEC), with the Childhood Autism Rating Scale (CARS)

Four distinct stages of human language evolution are suggested by clustering of speech and language comprehension abilities in individuals with language deficits

Human language evolution: clustering of fifteen language comprehension abilities in 55558 individuals suggests three-step-wise language comprehension acquisition

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