Longitudinal Decline in Pulmonary Function in an HIV+ Cohort Studied in the Era of Highly Active Antiretroviral Therapy (HAART).

Changes in lung function of HIV‐infected patients: a 4·5‐year follow‐up study

“…The finding, though, that seems most certainly attributable to the viral infection itself and not to associated lifestyle factors or known co‐morbidities is a reduced or declining DCLO in HIV‐infected patients in both the pre‐cART‐era and cART‐era and even in the absence of infectious or proliferative pulmonary disease (Kvale et al ., ; McCabe et al ., ; Diaz et al ., , ; Kadri et al ., ; Gingo et al ., ). These findings are reproduced in our data.…”

“…And indeed, signs of increased risk of obstructive lung disease in well‐managed HIV‐infected patients in the cART‐era have been reported in several cross‐sectional studies based on both ICD‐9 (International Classification of Diseases) codes (Crothers et al ., , ), computed tomography (Diaz et al ., ) and pulmonary function testing (Kadri et al ., ). Additionally, abnormal airway responsiveness has been reported in the initiation of the cART‐era (Poirier et al ., ), and reduced carbon monoxide diffusion capacity (DLCO) has been reported in several studies both before and after the introduction of cART (Kvale et al ., ; McCabe et al ., ; Diaz et al ., , ; Gingo et al ., ).…”