Longitudinal course of cognitive deficits in bipolar disorder: A meta-analytic study

Samamé, Cecilia; Martino, Diego Javier; Strejilevich, Sergio

doi:10.1016/j.jad.2014.04.028

Cited by 131 publications

(92 citation statements)

References 61 publications

(80 reference statements)

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“…However, evidence from primary studies has not shown any association between these variables (Bora et al, 2005;Martino et al, 2011;Barrera et al, 2012). Such findings are also in accordance with evidence from a recent meta-analysis suggesting a nonprogressive evolution of cognitive features in BDs (Samamé et al, 2014). Nonetheless, further longitudinal studies are needed to gain a better insight into the trajectories of social cognitive impairments in this group of disorders.…”

Section: Discussionsupporting

confidence: 84%

An individual task meta-analysis of social cognition in euthymic bipolar disorders

Samamé

Martino

Strejilevich

2015

Journal of Affective Disorders

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Section: Discussionsupporting

confidence: 84%

An individual task meta-analysis of social cognition in euthymic bipolar disorders

Samamé

Martino

Strejilevich

2015

Journal of Affective Disorders

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“…Secondly, our meta-analysis does not provide any information regarding the longitudinal trajectory of cognitive dysfunction from the early stage to the chronic phase of disease. We note here that previous longitudinal meta-analysis of cognitive deficits in BD suggested that there was not enough evidence to indicate that cognitive dysfunction was a progressive course [33]. More in-depth studies will be required to explore the development of cognition and the magnitude of neuropsychological deficits in BD.…”

Section: Discussionmentioning

confidence: 83%

Use of the MATRICS consensus cognitive battery (MCCB) to evaluate cognitive deficits in bipolar disorder: A systematic review and meta-analysis

Mao

et al. 2017

PLoS ONE

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BackgroundThe Measurement and Treatment Research to Improve Cognition Schizophrenia Consensus Cognitive Battery (MCCB) has also been proposed for use in clinical trials to assess cognitive deficits in patients with bipolar disorder (BD). The aim of this study was to evaluate cognitive function assessed by the MCCB in BD.MethodsA literature search of the PubMed, Embase, PsycINFO, SCI, Cochrane Library databases and the Cochrane Controlled Trials Register was conducted. Case reports, reviews and meta-analyses were excluded and a systematic review of the remaining studies of cognitive function in BD was carried out. The cognitive outcome measure was the MCCB, including 7 domains and overall cognition. A random-effects model was applied.ResultsEighty eight studies were initially identified. Seven clinical studies comprising a total of 487 patients and 570 healthy controls (HC) were included in the meta-analysis. Patients with BD performed worse than HC in overall cognition and processing speed with a large effect size of >0.8; with a medium effect size (0.5–0.8) in attention, working memory, verbal learning and visual learning; and with a small effect size (0.2–0.5) in reasoning and problem solving and social cognition.ConclusionPatients with BD performed worse than HC in overall cognition and all cognitive domains of the MCCB. Cognitive deficits in domains of processing speed and working memory are prominent in patients with BD. Our findings suggest that MCCB can be usefully applied in BD.

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“…Moreover, inconsistent findings between the extant cross-sectional and longitudinal studies highlight the necessity for further research to elucidate the veritable evolution of cognitive dysfunction in bipolar illness and potential selection bias in longitudinal studies, since disturbance progress following repeated episodes is not entirely clear. Most cross-sectional studies find an association between cognitive impairment and number of episodes, whereas the longitudinal ones indicate a stable pattern over time (Budde et al, 2014; Samame et al, 2014). During the last decade, different staging model approaches have been proposed for BD (Berk et al, 2007; Kapczinski et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Cognitive Impairment in Bipolar Disorder: Treatment and Prevention Strategies

Solé

Jiménez

Torrent³

et al. 2017

International Journal of Neuropsychopharmacology

209

138

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Over the last decade, there has been a growing appreciation of the importance of identifying and treating cognitive impairment associated with bipolar disorder, since it persists in remission periods. Evidence indicates that neurocognitive dysfunction may significantly influence patients’ psychosocial outcomes. An ever-increasing body of research seeks to achieve a better understanding of potential moderators contributing to cognitive impairment in bipolar disorder in order to develop prevention strategies and effective treatments. This review provides an overview of the available data from studies examining treatments for cognitive dysfunction in bipolar disorder as well as potential novel treatments, from both pharmacological and psychological perspectives. All these data encourage the development of further studies to find effective strategies to prevent and treat cognitive impairment associated with bipolar disorder. These efforts may ultimately lead to an improvement of psychosocial functioning in these patients.

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Longitudinal course of cognitive deficits in bipolar disorder: A meta-analytic study

Cited by 131 publications

References 61 publications

An individual task meta-analysis of social cognition in euthymic bipolar disorders

An individual task meta-analysis of social cognition in euthymic bipolar disorders

Use of the MATRICS consensus cognitive battery (MCCB) to evaluate cognitive deficits in bipolar disorder: A systematic review and meta-analysis

Cognitive Impairment in Bipolar Disorder: Treatment and Prevention Strategies

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