Longitudinal characterization of cerebral hemodynamics in the TgF344-AD rat model of Alzheimer’s disease

Fang, Xing; Tang, Chengyun; Zhang, Huawei; Border, Jane J.; Liu, Yedan; Shin, Seung-Soo; Yu, Hongwei; Roman, Richard J.; Fan, Fan

doi:10.1007/s11357-023-00773-x

Cited by 3 publications

(1 citation statement)

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“…These results are consistent with other studies that have reported increased body weights in female TgF344-AD compared to WT rats [22,23]. In contrast, increased body weight in the male TgF344-AD rats was transitory since no differences in weight between genotypes were observed at 12 months of age and this finding is consistent with other studies that found no difference in body weight between TGF344-AD and WT male animals [23,24]. The present study was unique, however, in that the rats were fed isocaloric amounts of diet.…”

Section: Discussionsupporting

confidence: 93%

The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats

Rutkowsky,

Roland,

Valenzuela

et al. 2024

Aging

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Studies suggest that ketogenic diets (KD) may improve memory in mouse models of aging and Alzheimer’s disease (AD). This study determined whether a continuous or intermittent KD (IKD) enhanced cognitive behavior in the TgF344-AD rat model of AD. At 6 months-old, TgF344-AD and wild-type (WT) littermates were placed on a control (CD), KD, or IKD (morning CD and afternoon KD) provided as two meals per day for 2 or 6 months. Cognitive and motor behavior and circulating β-hydroxybutyrate (BHB), AD biomarkers and blood lipids were assessed. Animals on a KD diet had elevated circulating BHB, with IKD levels intermediate to CD and KD. TgF344-AD rats displayed impaired spatial learning memory in the Barnes maze at 8 and 12 months of age and impaired motor coordination at 12 months of age. Neither KD nor IKD improved performance compared to CD. At 12 months of age, TgF344-AD animals had elevated blood lipids. IKD reduced lipids to WT levels with KD further reducing cholesterol below WT levels. This study shows that at 8 or 12 months of age, KD or IKD intervention did not improve measures of cognitive or motor behavior in TgF344-AD rats; however, both IKD and KD positively impacted circulating lipids.

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