Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model
Qing Cao,
Manasa Kumar,
Allea Frazier
et al.
Abstract:Neurodegenerative disorders, such as Alzheimer’s disease (AD), have the gradual onset of neurobiological changes preceding clinical diagnosis by decades. To elucidate how brain dysfunction proceeds in neurodegenerative disorders, we performed longitudinal characterization of behavioral, morphological, and transcriptomic changes in a tauopathy mouse model, P301S transgenic mice. P301S mice exhibited cognitive deficits as early as 3 months old, and deficits in social preference and social cognition at 5–6 months… Show more
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