Longitudinal Changes of Mineral Concentrations in Preterm and Term Human Milk from Lactating Swiss Women

Sabatier, Magalie; García-Ródenas, Clara L.; Castro, Carlos Antonio De; Kastenmayer, Peter; Vigo, M; Dubascoux, Stéphane; Andrey, Daniel; Nicolas, Marine; Payot, Janique Richoz; Bordier, Valentine; Thakkar, Sagar K.; Beauport, Lydie; Tolsa, Jean-François; Fumeaux, Céline J. Fischer; Affolter, Michael

doi:10.3390/nu11081855

Cited by 39 publications

(39 citation statements)

References 51 publications

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“…The present study highlights that Fe is a predominant essential micronutrient in HM-baseline and HM-concentrate samples ( Table 1 ). Previous studies conducted in Greece ( Leotsinidis et al, 2005 ), Sweden ( Björklund et al, 2012 ), Chile ( Castro et al, 2014 ), Australia ( Mohd-Taufek et al, 2016 ), Switzerland ( Sabatier et al, 2019 ), and Brazil ( Alves Peixoto et al, 2019 ) detected lower Fe content in breast milk compared to the values found in the present study ( Table A1 ). Furthermore, Fe content in HM samples collected 1–2 months postpartum was higher than in samples collected after 6–7 months and 12 months of lactation ( Taravati Javad et al, 2018 ).…”

Section: Resultscontrasting

confidence: 63%

Essential and toxic elements in human milk concentrate with human milk lyophilizate: A preclinical study

Oliveira

Trevilato

Aragon

et al. 2020

Environmental Research

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Concentrated human milk (HM-concentrate) can be obtained from the simple and inexpensive method of donated breast milk direct lyophilization. A previous study reported that HM-concentrate contains the adequate amount of main macro- and micronutrients for use as a nutritional resource for preterm infants with very low birth weight admitted to neonatal intensive care units. However, further details need to be elucidated about HM-concentrate composition, particularly its content of essential and potentially toxic trace elements. Therefore, this study aimed to determine the concentration of essential and toxic elements in human milk considered baseline (HM-baseline) and HM-concentrate, as well as to quantify changes in concentration of these elements after the HM concentration process. The concentration of Aluminum, Arsenic, Cadmium, Chromium, Iron, Mercury, Manganese, Nickel, Lead, Selenium, Tin, and Thallium was analyzed by inductively coupled plasma-mass spectrometry (ICP-MS). Moreover, Bayesian linear mixed effect models were applied to estimate the mean difference between HM-baseline and HM-concentrate samples. After comparison (HM-concentrate versus HM-baseline), a significant increase in concentration was observed only for Manganese (0.80 μg/L; 95% CrI [0.16; 1.43]) and Selenium (6.74 μg/L; 95% CrI [4.66; 8.86]), while Lead concentration (−6.13 μg/L; 95% CrI [-8.63; −3.61]) decreased. This study provides latest and reliable information about HM composition. After milk concentration by lyophilization, there was a significant increase only in the essential elements Manganese and Selenium. The essential micronutrient content in HM-concentrate was similar or higher than that in preterm mothers' milk, which suggests it is viable for nutritional support of preterm infants. In addition, the low concentrations of potentially toxic elements in HM-concentrate indicates that it is safe for consumption by premature newborns.

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Section: Resultscontrasting

confidence: 63%

Essential and toxic elements in human milk concentrate with human milk lyophilizate: A preclinical study

Oliveira

Trevilato

Aragon

et al. 2020

Environmental Research

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“…The composition of human milk varies throughout the lactation period as a result of internal and external factors, such as gestational age, maternal body mass index (BMI), smoking status, and even diet [1][2][3][4][5]. Past studies have demonstrated that the duration of lactation is a primary determinant of some nutrient contents, such as proteins and sodium [1,2,[6][7][8][9][10]. Other studies have been published qualifying breast milk volume as another determinant of protein and sodium contents [8,11,12].…”

Section: Introductionmentioning

confidence: 99%

Role of Daily Milk Volume and Period of Lactation in Nutrient Content of Human Milk: Results from a Prospective Study

Rigourd

Lopera

Cata³

et al. 2020

Nutrients

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Most studies assessing the macronutrient content of human milk are published retrospectively using analyzers that fail to determine sodium content and do not take into account the role of volume in milk composition. We aimed to describe macronutrient content and sodium content in human milk over time, observe any associations between them, and determine the factors associated with the evolution of milk composition. A prospective, longitudinal, monocentric study was undertaken. Contents of protein, fat, and lactose of 102 milk samples from 40 mothers were determined using a human milk analyzer and that of sodium with a flame spectrophotometer. Milk volumes along with clinical data were recorded. Protein content in the fourth quartile of volume was significantly lower than that in the first three, suggesting the existence of a volume threshold for protein content at approximately 445 mL. After multivariate analysis, it was found that maternal age, average volume, and lactation period remained significantly associated with protein content, maternal age remained significantly associated with fat content, and only average volume with sodium content. In consideration of previous findings along with our data, we suggest that extra care should be taken with fortification for feeding preterm infants when the mother’s milk volume is greater than 400–450 mL.

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“…BMIC is impacted by the maternal degree of iodine sufficiency from dietary iodine sources or supplementation. BMIC also varies based on the time point during lactation, maternal smoking, maternal health conditions, and with day to day fluctuation [3,[15][16][17][18][19]. In establishing maternal iodine insufficiency, iodine is thought to be secreted into breast milk rather than excreted into the urine, to promote adequate levels of intake for offspring.…”

Section: Introductionmentioning

confidence: 99%

Breast Milk Iodine Concentration Is Associated with Infant Growth, Independent of Maternal Weight

et al. 2020

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In breastfed infants, human milk provides the primary source of iodine to meet demands during this vulnerable period of growth and development. Iodine is a key micronutrient that plays an essential role in hormone synthesis. Despite the importance of iodine, there is limited understanding of the maternal factors that influence milk iodine content and how milk iodine intake during infancy is related to postnatal growth. We examined breast milk samples from near 2 weeks and 2 months post-partum in a mother-infant dyad cohort of mothers with pre-pregnancy weight status defined by body mass index (BMI). Normal (NW, BMI < 25.0 kg/m2) is compared to overweight/obesity (OW/OB, BMI ≥ 25.0 kg/m2). The milk iodine concentration was determined by inductively coupled plasma mass spectrometry. We evaluated the associations between iodine content at 2 weeks and infant anthropometrics over the first year of life using multivariable linear mixed modeling. Iodine concentrations generally decreased from 2 weeks to 2 months. We observed no significant difference in iodine based on maternal weight. A higher iodine concentration at 2 weeks was associated with a larger increase in infant weight-for-age and weight-for-length Z-score change per month from 2 weeks to 1 year. This pilot study shows that early iodine intake may influence infant growth trajectory independent of maternal pre-pregnancy weight status.

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Longitudinal Changes of Mineral Concentrations in Preterm and Term Human Milk from Lactating Swiss Women

Cited by 39 publications

References 51 publications

Essential and toxic elements in human milk concentrate with human milk lyophilizate: A preclinical study

Essential and toxic elements in human milk concentrate with human milk lyophilizate: A preclinical study

Role of Daily Milk Volume and Period of Lactation in Nutrient Content of Human Milk: Results from a Prospective Study

Breast Milk Iodine Concentration Is Associated with Infant Growth, Independent of Maternal Weight

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