Longitudinal changes in MR T1ρ/T2 signal of meniscus and its association with cartilage T1p/T2 in ACL-injured patients

Knox, Joseph; Pedoia, Valentina; Wang, A.; Tanaka, Miho J.; Joseph, G.B.; Neumann, Jan; Link, Thomas M.; Li, X.; Ma, Cong

doi:10.1016/j.joca.2018.02.001

Cited by 22 publications

(17 citation statements)

References 49 publications

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“…The qDESS sequence in the present study was optimized to simultaneously generate high-resolution images and quantitative measurements, by combining high spatial resolution with high SNR, in one single, rapid scan. While twice as fast, the resolution and voxel volume of this qDESS sequence (0.18 μL) was over 10x better than the resolution of established quantitative T 2 sequences [7,30]. In a previous study, qDESS has shown high T 2 accuracy compared with multi-echo spin echo sequences, as well as high accuracy for MOAKS measurements compared with conventional spin echo-based sequences, with high intra-and inter-observer reproducibility [16,25].…”

Section: Discussionmentioning

confidence: 80%

Time-saving opportunities in knee osteoarthritis: T2 mapping and structural imaging of the knee using a single 5-min MRI scan

et al. 2019

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Objectives To assess the discriminative power of a 5-min quantitative double-echo steady-state (qDESS) sequence for simultaneous T 2 measurements of cartilage and meniscus, and structural knee osteoarthritis (OA) assessment, in a clinical OA population, using radiographic knee OA as reference standard. Methods Fifty-three subjects were included and divided over three groups based on radiographic and clinical knee OA: 20 subjects with no OA (Kellgren-Lawrence grade (KLG) 0), 18 with mild OA (KLG2), and 15 with moderate OA (KLG3). All patients underwent a 5-min qDESS scan. We measured T 2 relaxation times in four cartilage and four meniscus regions of interest (ROIs) and performed structural OA evaluation with the MRI Osteoarthritis Knee Score (MOAKS) using qDESS with multiplanar reformatting. Between-group differences in T 2 values and MOAKS were calculated using ANOVA. Correlations of the reference standard (i.e., radiographic knee OA) with T 2 and MOAKS were assessed with correlation analyses for ordinal variables. Results In cartilage, mean T 2 values were 36.1 ± SD 4.3, 40.6 ± 5.9, and 47.1 ± 4.3 ms for no, mild, and moderate OA, respectively (p < 0.001). In menisci, mean T 2 values were 15 ± 3.6, 17.5 ± 3.8, and 20.6 ± 4.7 ms for no, mild, and moderate OA, respectively (p < 0.001). Statistically significant correlations were found between radiographic OA and T 2 and between radiographic OA and MOAKS in all ROIs (p < 0.05). Conclusion Quantitative T 2 and structural assessment of cartilage and meniscus, using a single 5-min qDESS scan, can distinguish between different grades of radiographic OA, demonstrating the potential of qDESS as an efficient tool for OA imaging. Key Points • Quantitative T 2 values of cartilage and meniscus as well as structural assessment of the knee with a single 5-min quantitative double-echo steady-state (qDESS) scan can distinguish between different grades of knee osteoarthritis (OA). • Quantitative and structural qDESS-based measurements correlate significantly with the reference standard, radiographic degree of OA, for all cartilage and meniscus regions. • By providing quantitative measurements and diagnostic image quality in one rapid MRI scan, qDESS has great potential for application in large-scale clinical trials in knee OA. AbbreviationsACR American College of Rheumatology KLG Kellgren and Lawrence grade MOAKS MRI Osteoarthritis Knee Score MRI Magnetic resonance imaging OA Osteoarthritis qDESS Quantitative double-echo steady-state ROI Region of interest SD Standard deviation TE Echo time 95% CI 95% confidence intervalPublisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Section: Discussionmentioning

confidence: 80%

Time-saving opportunities in knee osteoarthritis: T2 mapping and structural imaging of the knee using a single 5-min MRI scan

et al. 2019

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“…101 Therefore, with degradation of the cartilage matrix, there is a resultant loss of PG and subsequent measurable increases in T1rho values. [102][103][104][105] T1rho values appear to have a good correlation with histologic assessment of PG. 100,103 One of its main advantages as a modality in evaluating PG distribution is that it does not use contrast, as required with the dGEMRIC technique.…”

Section: T1rho Mappingmentioning

confidence: 76%

“…[102][103][104][105] T1rho values appear to have a good correlation with histologic assessment of PG. 100,103 One of its main advantages as a modality in evaluating PG distribution is that it does not use contrast, as required with the dGEMRIC technique. As with other quantitative MRI techniques, T1rho has been primarily utilized in evaluating knee cartilage and menisci, but more recent work evaluated its utility in the hip, particularly in the context of FAI.…”

Section: T1rho Mappingmentioning

confidence: 76%

Standard and Advanced Imaging of Hip Osteoarthritis. What the Radiologist Should Know

Huang

Tan

Scherer

et al. 2019

Semin Musculoskelet Radiol

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Osteoarthritis (OA) of the hip is caused by degeneration of articular cartilage and the underlying bone and can be divided into two types: primary (associated with advancing age) and secondary (subsequent to fractures, avascular necrosis, infection, developmental dysplasia, and femoroacetabular impingement). Radiography remains the first-line imaging modality for diagnosing and monitoring OA, due to its accessibility, low cost, and ease of interpretation. Kellgren-Lawrence and Tönnis classification systems are radiographic OA grading systems used primarily in research, and they reflect the degree of joint space narrowing, sclerosis, cysts, deformity of the femoral head and acetabulum, and osteophytes. Unenhanced computed tomography (CT) provides detailed visualization of the hip joint segments that may be difficult to appreciate on radiographs, such as the inferoposterior and posterolateral hip joint. CT arthrography, magnetic resonance imaging (MRI), and magnetic resonance arthrography with two-dimensional reconstructions can delineate labral abnormalities, cartilage lesions, and other intra-articular hip pathology. T2 and T2* mapping, delayed gadolinium-enhanced MRI of cartilage, T1rho, ultra-short echo time, and zero echo time are investigative MR techniques with promising evaluation of hip OA.

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“…37 Given the similarities to articular cartilage, T 1 ρ and T 2 mapping allow for detailed evaluation of the meniscus. 38,39 T 2 * has been shown to be significantly longer in degenerative menisci relative to normal meniscal tissue. Intrasubstance degeneration of the meniscus may also be evaluated with dGEMRIC, given its ability to reflect the proteoglycan content of the tissue.…”

Section: Meniscus Imagingmentioning

confidence: 98%

Clinical Utility of Advanced Imaging of the Knee

Lansdown

Benjamin

2019

Journal Orthopaedic Research

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Advanced imaging modalities, including computed tomography, magnetic resonance imaging (MRI), and dynamic fluoroscopic imaging, allow for a comprehensive evaluation of the knee joint. Compositional sequences for MRI can allow for an evaluation of the biochemical properties of cartilage, meniscus, and ligament that offer further insight into pathology that may not be apparent on conventional clinical imaging. Advances in image processing, shape modeling, and dynamic studies also offer a novel way to evaluate common conditions and to monitor patients after treatment. The purpose of this article is to review advanced imaging modalities of the knee and their current and anticipated future applications to clinical practice. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:473–482, 2020

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Longitudinal changes in MR T1ρ/T2 signal of meniscus and its association with cartilage T1p/T2 in ACL-injured patients

Cited by 22 publications

References 49 publications

Time-saving opportunities in knee osteoarthritis: T2 mapping and structural imaging of the knee using a single 5-min MRI scan

Time-saving opportunities in knee osteoarthritis: T2 mapping and structural imaging of the knee using a single 5-min MRI scan

Standard and Advanced Imaging of Hip Osteoarthritis. What the Radiologist Should Know

Clinical Utility of Advanced Imaging of the Knee

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