Longitudinal changes in maternal soluble endoglin and angiopoietin‐2 in women at risk for pre‐eclampsia

Khalil, Asma; Maíz, Nerea; Garcia-Mandujano, R.; Elkhouli, M.; Nicolaides, Kypros H.

doi:10.1002/uog.13439

Cited by 15 publications

(5 citation statements)

References 56 publications

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“…We also found evidence of a weak association between low endoglin and preeclampsia in women with normal BMI. This concurs with previous reports of lower endoglin to be a predictor of preeclampsia but when measured later than in this study, i.e., in the late second trimester (after 19 weeks) . Insulin sensitivity has been suggested to underpin the increased risk of preeclampsia in women with obesity or gestational diabetes , and it was of interest that we found no strong association of adipokines or insulin resistance markers with preeclampsia in the SCOPE women with obesity.…”

Section: Discussionsupporting

confidence: 92%

Clinical and biochemical factors associated with preeclampsia in women with obesity

Vieira

Poston

Fyfe

et al. 2016

Obesity

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Conflict of interest statement: L.C. Kenny and P.N. Baker are minority shareholders in 30Metabolomic Diagnostics, a campus-based spin-out that has licensed technology concerning 31 the use of metabolomics biomarkers in the prediction of preeclampsia. L.C. Kenny and J.E. 32Myers have received consultancy fees and honoraria payments from Alere relating to the 33 Triage PlGF test for the prediction of complications in women with suspected preeclampsia. 34The other authors report no conflicts. The SCOPE database is provided and maintained by MedSciNet AB (http://medscinet.com).

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Section: Discussionsupporting

confidence: 92%

Clinical and biochemical factors associated with preeclampsia in women with obesity

Vieira

Poston

Fyfe

et al. 2016

Obesity

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“…The increase in sEng in PE patients was previously reported [35,36]. pathophysiology of PE [37]. Soluble Eng levels are independently associated with the development and severity of PE [38].…”

Section: Characteristics Clinical and Circulating Angiogenesis Biomasupporting

confidence: 52%

Effect of Serum Copper on Circulating Angiogenesis-Related Factors in Women with Preeclampsia

Nadheer¹,

Zahraei²,

Al‐Hakeim³

2019

Preprint

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Preeclampsia (PE) is characterized by a series of clinical features such as hypertension and proteinuria associated with endothelial dysfunction and the impairment of placenta vascular endothelial integrity. This study aimed to investigate the effect of serum copper (Cu) level on some angiogenesis-related factors including vascular endothelial growth factor-A (VEGF-A), soluble Fms-like tyrosine kinase-1 (sVEGF-R1), soluble endoglin (sEng) and cerruloplasmin (Cp) in Iraqi women with preeclampsia (PE) and control pregnant women. Therefore, 60 women with PE in addition to 30 healthy pregnant women were enrolled in the study. Serum concentration of sEng, VEGF-A, sVEGF-R1, and Cu in PE group significantly increased (p<0.05) in the PE group compared with that in the control group. Increased production of antiangiogenic factors, soluble VEGF-A and sEng contribute to the pathophysiology of PE, indicating the involvement of these parameters in the angiogenic balance in patients with PE. Tests for between-subject effects showed that the circulating angiogenesis factors and Cu were significantly associated with the presence of PE. Serum Cu level was significantly correlated with VEGF- A and VEGF-R1 levels but not with sEng. Multiple regression analysis revealed that only Cp and BP can significantly predict the complications in women with PE. In conclusion, serum Cu has a role in the angiogenesis in women with PE and may be a new drug target in the prevention or treatment of PE.

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“…Han et al [49] suggested that maternal plasma Ang-2 level increases in severe PE. Although many recent studies suggest a link between maternal serum Angs-1 and -2 levels [21,[48][49][50][51][52], there is no study that assessed the value of Angs-1 and -2 as biomarkers of HELLP syndrome. According to our findings, patients with HELLP syndrome have higher Angs-1 and -2 levels, though the increase of Ang-2 is more meaningful.…”

Section: Discussionmentioning

confidence: 97%

Serum levels of ET-1, M30, and angiopoietins-1 and -2 in HELLP syndrome and preeclampsia compared to controls

Karakuş

Akkar

Yıldız

et al. 2015

Arch Gynecol Obstet

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Longitudinal changes in maternal soluble endoglin and angiopoietin‐2 in women at risk for pre‐eclampsia

Abstract: Objective To investigate longitudinal changes in maternal plasma levels of soluble endoglin (sEng) and angiopoietin-2 (Ang-2) in pregnant women who develop pre-eclampsia (PE) and gestational hypertension (GH). Methods

Cited by 15 publications

References 56 publications

Clinical and biochemical factors associated with preeclampsia in women with obesity

Clinical and biochemical factors associated with preeclampsia in women with obesity

Effect of Serum Copper on Circulating Angiogenesis-Related Factors in Women with Preeclampsia

Serum levels of ET-1, M30, and angiopoietins-1 and -2 in HELLP syndrome and preeclampsia compared to controls

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