Longitudinal changes in maternal corin and mid‐regional proatrial natriuretic peptide in women at risk of pre‐eclampsia

Khalil, Asma; Maíz, Nerea; Garcia-Mandujano, R.; Elkhouli, M.; Nicolaides, Kypros H.

doi:10.1002/uog.14685

Cited by 31 publications

(18 citation statements)

References 79 publications

(103 reference statements)

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“…In humans, CORIN variants associated with preeclampsia were reported in a Caucasian population (Stepanian et al, 2014) and CORIN mutations reducing corin activity were identified in preeclamptic patients (Cui et al, 2012; Dong et al, 2014). Consistent with these findings, low levels of plasma corin were associated with the risk of preeclampsia (Khalil et al, 2015). …”

Section: Biological Functions Of Anpsupporting

confidence: 69%

Atrial natriuretic peptide in cardiovascular biology and disease (NPPA)

Song

Wang

2015

Gene

155

101

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Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates salt-water balance and blood pressure by promoting renal sodium and water excretion and stimulating vasodilation. ANP also has an anti-hypertrophic function in the heart, which is independent of its systemic blood pressure-lowering effect. In mice, ANP deficiency causes salt-sensitive hypertension and cardiac hypertrophy. Recent studies have shown that ANP plays an important role in regulating vascular remodeling and energy metabolism. Variants in the human NPPA gene, encoding the ANP precursor, are associated with hypertension, stroke, coronary artery disease, heart failure (HF) and obesity. ANP and related peptides are used as biomarkers for heart disease. Recombinant proteins and small molecules that enhance the ANP pathway have been developed to treat patients with HF. In this review, we discuss the role of ANP in cardiovascular biology and disease.

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Section: Biological Functions Of Anpsupporting

confidence: 69%

Atrial natriuretic peptide in cardiovascular biology and disease (NPPA)

Song

Wang

2015

Gene

155

101

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“…Corin and MR-PANP levels were significantly altered in preterm-PE cases compared to normotensive controls (p=0.001 and p=0.046 respectively). Both the markers did not show significant change for term-PE cases [45]. The study showed significantly reduced levels of corin in women destined to develop PE.…”

Section: Accepted Manuscriptmentioning

confidence: 86%

Promising prognostic markers of Preeclampsia: New avenues in waiting

Jadli

Sharma

Damania

et al. 2015

Thrombosis Research

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“…High levels of plasma corin were found in patients with atrial fibrillation [79]. In pregnant women, increased plasma corin levels were associated with gestational age and hypertension [54,80–82]. Khalil et al .…”

Section: Plasma Soluble Corin In Heart Disease and Strokementioning

confidence: 99%

“…Khalil et al . [80] reported that plasma corin levels before 20 weeks of gestation were lower in one-third of pre-eclamptic women compared with normotensive controls, suggesting that reduced plasma corin may be a predictor for pre-eclampsia. At this time, the tissue-origin and activity of the circulating corin remain unclear, making it difficult to interpret the data.…”

Section: Plasma Soluble Corin In Heart Disease and Strokementioning

confidence: 99%

Role of corin in the regulation of blood pressure

Zhang²,

2016

Current Opinion in Nephrology and Hypertension

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Purpose of review Corin is a transmembrane protease that activates atrial natriuretic peptide (ANP), an important hormone in regulating salt-water balance and blood pressure. This review focuses on the regulation of corin function and potential roles of corin defects in hypertensive, heart, and renal diseases. Recent findings Proprotein convertase subtilisin/kexin-6 has been identified as a primary enzyme that converts zymogen corin to an active protease. Genetic variants that impair corin intracellular trafficking, cell surface expression, and zymogen activation have been found in patients with hypertension, cardiac hypertrophy, and pre-eclampsia. Reduced corin expression has been detected in animal models of cardiomyopathies and in human failing hearts. Low levels of circulating soluble corin have been reported in patients with heart disease and stroke. Corin, ANP and natriuretic peptide receptor-A mRNAs, and proteins have been colocalized in human renal segments, suggesting a corin-ANP autocrine function in the kidney. Summary Corin is a key enzyme in the natriuretic peptide system. The latest findings indicate that corin-mediated ANP production may act in a tissue-specific manner to regulate cardiovascular and renal function. Corin defects may contribute to major diseases such as hypertension, heart failure, pre-eclampsia, and kidney disease

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Longitudinal changes in maternal corin and mid‐regional proatrial natriuretic peptide in women at risk of pre‐eclampsia

Abstract: ABSTRACT

Cited by 31 publications

References 79 publications

Atrial natriuretic peptide in cardiovascular biology and disease (NPPA)

Atrial natriuretic peptide in cardiovascular biology and disease (NPPA)

Promising prognostic markers of Preeclampsia: New avenues in waiting

Role of corin in the regulation of blood pressure

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