Longitudinal changes in insulin resistance in children with epilepsy on ketogenic diet: Prevalence and risk factors

Kong, Jai-Yul; Nam, Sang Ook; Ko, Ara; Byun, Shin Yun; Lim, Taek Jin; Kim, Young Mi; Yeon, Gyu Min; Cho, Jae Wook; Lee, Yun-Jin

doi:10.1016/j.yebeh.2020.107393

Cited by 2 publications

(3 citation statements)

References 25 publications

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“…Ketogenic diet has various beneficial effects on numerous organs and tissues, inducing weight loss, reducing blood insulin levels and cardiovascular risk factors, increasing mitochondriogenesis, and modulating neurotransmitter activity, as well as improving vascular density in the brain (34). Ketogenic diet also has an important role as a signalling mediator, driver of protein post-translational modification, and modulator of inflammation and oxidative stress (34)(35)(36). Mild dietary ketosis is a normal physiological mechanism, and the protective role of ketone bodies has been proposed (37).…”

Section: The Role Of Ketogenic Diet In Epilepsy Treatmentmentioning

confidence: 99%

“…Mild dietary ketosis is a normal physiological mechanism, and the protective role of ketone bodies has been proposed (37). Ketogenic diet can reduce epileptic seizures, for example, of drug-resistant epilepsy in children (31,32,35). The mechanism of action of ketogenic diet in the control of epilepsy is still unclear because epilepsy is thought to have multifactorial etiopathogenesis.…”

Section: The Role Of Ketogenic Diet In Epilepsy Treatmentmentioning

confidence: 99%

“…Most of the clinical cases of epilepsy and GLUT1-DS reported in the literature reveal an important gap between the clinical onset and the time of diagnosis of the syndrome. The most important factor for predictive outcome is age at diagnosis because the effectiveness of the diet decreases when it is started in late childhood (33,35,41,42).…”

Section: The Role Of Ketogenic Diet In Epilepsy Treatmentmentioning

confidence: 99%

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The Role of Milk Nutrition and Ketogenic Diet in Epileptic Disorders

Ciliberti,

Santillo,

Polito

et al. 2022

Epilepsy

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This chapter explores the role of the gut-brain axis, ketogenic diet, and cow's milk allergy on epileptic seizures, with a special focus on childhood. Milk nutrition is particularly relevant for normal growth and health in childhood; however, some studies report an association between cow's milk allergy and epileptic events. It is necessary to clarify the role of protein polymorphisms in these events and the influence of milk protein fractions on gut microbiota in Note to the Reader: This chapter is part of the book Epilepsy (ISBN: 978-0-6453320-4-9), scheduled for publication in March 2022. The book is being published by Exon Publications,

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Section: The Role Of Ketogenic Diet In Epilepsy Treatmentmentioning

confidence: 99%

Section: The Role Of Ketogenic Diet In Epilepsy Treatmentmentioning

confidence: 99%

Section: The Role Of Ketogenic Diet In Epilepsy Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

The Role of Milk Nutrition and Ketogenic Diet in Epileptic Disorders

Ciliberti,

Santillo,

Polito

et al. 2022

Epilepsy

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Effect of the ketogenic diet in excitable tissues

Murano

Binda

Palestini

et al. 2021

American Journal of Physiology-Cell Physiology

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In the last decade Ketogenic Diet (KD) came to light as a potential treatment for a wide range of diseases, from neurological to metabolic disorders, thanks to a beneficial role mainly related to its anti-inflammatory properties. The high-fat, carbohydrate-restricted regimen causes changes in the metabolism leading, through the β-oxidation of fatty acids, to the hepatic production of ketone bodies (KBs), used by many extrahepatic tissues as energy fuels. Once synthetized, KBs move through the systemic circulation and reach all the tissues of the organism, affecting their functions and playing pleiotropic roles acting directly and indirectly on various targets as ion channels and neurotransmitters. Moreover, they can operate as signalling metabolites and epigenetic modulators. Therefore, it is limiting to consider that the clinical condition of each single patient could improve after a KD regimen based on its localized effects; rather it is more complete to think about how KBs might affect the organism as a whole. In this minireview, we tried to summarize the recent knowledge of the effects of KBs on various tissues, with a particular attention to the excitable ones, namely the nervous system, heart and muscles.

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Longitudinal changes in insulin resistance in children with epilepsy on ketogenic diet: Prevalence and risk factors

Cited by 2 publications

References 25 publications

The Role of Milk Nutrition and Ketogenic Diet in Epileptic Disorders

The Role of Milk Nutrition and Ketogenic Diet in Epileptic Disorders

Effect of the ketogenic diet in excitable tissues

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